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- Carlisle, Robert C., et al. Show all 5 Authors
- Journal of Controlled Release 2016 v.238 pp. 22-30
- animal models; antibodies; drug formulations; hydrogels; immune response; immunoglobulin G; nanoparticles; ovalbumin; swine; ultrasonic treatment; vaccination; vaccines
- ... Inertial cavitation mediated by ultrasound has been previously shown to enable skin permeabilisation for transdermal drug and vaccine delivery, by sequentially applying the ultrasound then the therapeutic in liquid form on the skin surface. Using a novel hydrogel dosage form, we demonstrate that the use of sub-micron gas-stabilising polymeric nanoparticles (nanocups) to sustain and promote cavitat ...
- Carlisle, Robert C., et al. Show all 7 Authors
- Journal of controlled release 2013 v.169 no.1-2 pp. 40-47
- acoustics; blood flow; drugs; gene expression; microbubbles; monitoring; neoplasm cells; neoplasms; technology; ultrasonics; viruses
- ... Oncolytic viruses (OV) and ultrasound-enhanced drug delivery are powerful novel technologies. OV selectively self-amplify and kill cancer cells but their clinical use has been restricted by limited delivery from the bloodstream into the tumor. Ultrasound has been previously exploited for targeted release of OV in vivo, but its use to induce cavitation, microbubble oscillations, for enhanced OV tum ...