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You searched for: Author "Carmen De Kock" Remove constraint Author: "Carmen De Kock"
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1. Age Estimate of GJB2-p.(Arg143Trp) Founder Variant in Hearing Impairment in Ghana, Suggests Multiple Independent Origins across Populations

Author:
Carmen de Kock,   et al.   ; Elvis Twumasi Aboagye; Samuel Mawuli Adadey; Kevin Esoh; Mario Jonas; Lucas Amenga-Etego; Gordon A. Awandare; Ambroise Wonkam;     Show all 8 Authors
Source:
Biology 2022 v.11 no.3 pp. -
ISSN:
2079-7737
Subject:
Bayesian theory; age determination; ancestry; connexins; gap junctions; genes; genetic background; genomics; haplotypes; homozygosity; linkage disequilibrium; Ghana
Abstract:
... Gap junction protein beta 2 (GJB2) (connexin 26) variants are commonly implicated in non-syndromic hearing impairment (NSHI). In Ghana, the GJB2 variant p.(Arg143Trp) is the largest contributor to NSHI and has a reported prevalence of 25.9% in affected multiplex families. To date, in the African continent, GJB2-p.(Arg143Trp) has only been reported in Ghana. Using whole-exome sequencing data from 3 ...
DOI:
10.3390/biology11030476

2. Antiplasmodial and antimycobacterial activities of crude and lead-like enhanced extracts from Namibian medicinal plants

Author:
Carmen de Kock,   et al.   ; Celestine Raidron; Audrey Jordaan; Ronnett Seldon; Digby F. Warner; Dale Taylor; Stefan Louw; Suthananda Sunassee; Renate Hazel Hans;     Show all 9 Authors
Source:
Journal of ethnopharmacology 2022 v.295 pp. 115389
ISSN:
0378-8741
Subject:
Mycobacterium tuberculosis; Plasmodium falciparum; active ingredients; antibacterial properties; antimalarials; antiplasmodial properties; cinnamic acid; coumaric acids; fractionation; lactate dehydrogenase; malaria; methanol; minimum inhibitory concentration; nuclear magnetic resonance spectroscopy; parasites; phytochemicals; solid phase extraction; tandem mass spectrometry; traditional medicine; tuberculosis
Abstract:
... Eight indigenous medicinal plants which are used traditionally for the treatment of tuberculosis (TB), malaria, and associated symptoms, were selected for this study. The aim of this study was to evaluate the antiplasmodial and antimycobacterial activities of the organic and aqueous crude extracts of different plant parts, by comparing the activities of subfractions (lead-like enhanced [LLE] extra ...
DOI:
10.1016/j.jep.2022.115389

3. A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family

Author:
Carmen de Kock,   et al.   ; Noluthando Manyisa; Isabelle Schrauwen; Leonardo Alves de Souza Rios; Shaheen Mowla; Cedrik Tekendo-Ngongang; Kalinka Popel; Kevin Esoh; Thashi Bharadwaj; Liz M. Nouel-Saied; Anushree Acharya; Abdul Nasir; Edmond Wonkam-Tingang; Collet Dandara; Suzanne M. Leal; Ambroise Wonkam;     Show all 16 Authors
Source:
Genes 2021 v.12 no.11 pp. -
ISSN:
2073-4425
Subject:
DNA; computer simulation; cysteine; disulfides; mutants; mutation; South Africa
Abstract:
... Hearing impairment (HI) is a sensory disorder with a prevalence of 0.0055 live births in South Africa. DNA samples from a South African family presenting with progressive, autosomal dominant non-syndromic HI were subjected to whole-exome sequencing, and a novel monoallelic variant in REST [c.1244GC; p.(C415S)], was identified as the putative causative variant. The co-segregation of the variant was ...
DOI:
10.3390/genes12111765

4. Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate

Author:
Carmen de Kock,   et al.   ; Clinton G.L. Veale; Adrienne L. Edkins; Jo-Anne de la Mare; Peter J. Smith; Setshaba D. Khanye;     Show all 6 Authors
Source:
Tetrahedron letters 2015 v.56 no.14 pp. 1860-1864
ISSN:
0040-4039
Subject:
Lewis acids; Lewis bases; amides; antimalarials; antineoplastic activity; carboxylic acids; catalysts; chemical reactions; chemical structure; esters
Abstract:
... The synthesis of biologically relevant amides and esters is routinely conducted under complex reaction conditions or requires the use of additional catalysts in order to generate sensitive electrophilic species for attack by a nucleophile. Here we present the synthesis of different indolic esters and amides from indolyl-3-carbonyl nitrile, without the requirement of anhydrous reaction conditions o ...
DOI:
10.1016/j.tetlet.2015.02.090

5. Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties

Author:
Carmen De Kock,   et al.   ; Muneebah Adams; Tameryn Stringer; Peter J. Smith; Kirkwood M. Land; Nicole Liu; Christina Tam; Luisa W. Cheng; Mathew Njoroge; Kelly Chibale; Gregory S. Smith;     Show all 11 Authors
Source:
Dalton Trans 2016 v.45 no.47 pp. 19086-19095
ISSN:
1477-9226
Subject:
Chinese hamsters; Escherichia coli; Lactobacillus; Plasmodium falciparum; Trichomonas vaginalis; X-ray diffraction; animal ovaries; antimalarials; antiparasitic properties; carbon; cells; chemical structure; cytotoxicity; growth retardation; humans; liver microsomes; microbiome; parasites; pathogens; quinolines; screening; strains
Abstract:
... Bioisosteric ferrocenyl-containing quinolines and ferrocenylamines containing organosilanes and their carbon analogues, were prepared and fully characterised. The molecular structures of two ferrocenyl- containing quinolines, determined using single-crystal X-ray diffraction, revealed that the compounds crystallise in a folded conformation. The compounds were screened for their antiplasmodial acti ...
Handle:
10113/5678136
DOI:
10.1039/C6DT03175G

6. Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics

Author:
Carmen De Kock,   et al.   ; Tameryn Stringer; Hajira Guzgay; John Okombo; Jenny Liu; Sierra Kanetake; Jihwan Kim; Christina Tam; Luisa W. Cheng; Peter J. Smith; Denver T. Hendricks; Kirkwood M. Land; Timothy J. Egan; Gregory S. Smith;     Show all 14 Authors
Source:
Dalton Transactions 2016 v.45 no.34 pp. 13415-13426
ISSN:
1477-9226
Subject:
Plasmodium falciparum; Trichomonas vaginalis; X-ray diffraction; antiparasitic properties; bacteria; cell lines; chemical structure; chloroquine; cytotoxicity; esophagus; in vitro studies; neoplasm cells; neoplasms; parasites; pathogens; polyamines; quinoline; screening
Abstract:
... A series of mono- and multimeric polyamine-containing ferrocenyl complexes containing a quinoline motif were prepared. The complexes were characterised by standard techniques. The molecular structure of the monomeric salicylaldimine derivative was elucidated using single crystal X-ray diffraction and was consistent with the proposed structure. The antiplasmodial activity of the compounds were eval ...
Handle:
10113/63169
DOI:
10.1039/C6DT02685K