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- Caron, Kathleen M., et al. Show all 6 Authors
- Peptides 2019 v.112 pp. 96-100
- adulthood; animal models; antihypertensive effect; cytoskeleton; females; gene overexpression; heart; innate immunity; messenger RNA; mice; peptides; signal transduction
- ... Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are small peptides derived from a common precursor, pre-proadrenomedullin. Although AM and PAMP share hypotensive effects in the cardiovascular system, the peptides also exert diverse and distinct effects on endocrine physiology, innate immunity, cytoskeletal biology and receptor signaling pathways. Tremendous knowledge has bee ...
- Caron, Kathleen M., et al. Show all 2 Author
- Cellular and molecular life sciences 2015 v.72 no.16 pp. 3115-3126
- G-protein coupled receptors; endothelial cells; humans; lymphatic system
- ... Over the past decade, we have begun to appreciate that the lymphatic vascular system does more than simply return plasma back into the circulatory system and, in fact, contributes to a wide variety of normal and disease states. For this reason, much research has been devoted to understanding how lymphatic vessels form and function, with a particular interest in which molecules contribute to lympha ...
- Caron, Kathleen, et al. Show all 5 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.9 pp. 3420-3425
- blood pressure; diabetic nephropathy; females; fibrosis; gene expression; genetic variation; heart; humans; hypertension; hypertrophy; hypotension; kidneys; lipopolysaccharides; males; messenger RNA; mice; pregnancy; proteinuria; renin; sepsis (infection); transgenes
- ... Adrenomedullin (AM) is a potent vasodilator peptide in plasma at picomolar levels. Polymorphisms in the human AM gene have been associated with genetic predisposition to diabetic nephropathy and proteinuria with essential hypertension, and numerous studies have demonstrated that endogenous AM plays a role in protecting the heart and kidneys from fibrosis resulting from cardiovascular disease. Elev ...
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