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- Chakraborty, Prasun, et al. Show all 2 Author
- Nucleic acids research 2010 v.38 no.14 pp. 4722-4730
- DNA helicases; DNA repair; DNA replication; RNA helicases; genes; humans; hybrids; mutation; neoplasms; nuclear genome; nucleic acids; protein-protein interactions; transcription (genetics)
- ... Mutations in the Werner gene promote the segmental progeroid Werner syndrome (WS) with increased genomic instability and cancer. The Werner gene encodes a DNA helicase (WRN) that can engage in direct protein-protein interactions with DHX9, also known as RNA helicase A or nuclear DNA helicase II, which represents an essential enzyme involved in transcription and DNA repair. By using several synthet ...
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