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1. The concurrent treatment of Scutellaria baicalensis Georgi enhances the therapeutic efficacy of cisplatin but also attenuates chemotherapy-induced cachexia and acute kidney injury

Author:
Chan, Yi-Lin,   et al.   ; Huang, Tse-Hung; Wu, Tsung-Han; Guo, Yi-Hui; Li, Tsung-Lin; Wu, Chang-Jer;     Show all 6 Authors
Source:
Journal of ethnopharmacology 2019 v.243 pp. 112075
ISSN:
0378-8741
Subject:
Scutellaria baicalensis; acute kidney injury; antineoplastic activity; apoptosis; blood cell counts; blood serum; boiling; cachexia; cisplatin; creatinine; drug therapy; freeze drying; herbal medicines; inflammation; kidneys; lung neoplasms; males; mice; muscles; patients; synergism; traditional medicine; viability; white adipose tissue
Abstract:
... Cisplatin is an important chemotherapy to lung cancer, but it usually induces severe cachexia and acute kidney injury in patients. Scutellaria baicalensis Georgi (SB), commonly known as a skullcap, is a popular Chinese herbal medicine mainly used to treat inflammation, infection, and malignancy. In this study, we report the synergic effect of SB and cisplatin to Lewis lung carcinoma (LLC) cells, a ...
DOI:
10.1016/j.jep.2019.112075

2. Antitumor, Inhibition of Metastasis and Radiosensitizing Effects of Total Nutrition Formula on Lewis Tumor-Bearing Mice

Author:
Chan, Yi-Lin,   et al.   ; Liu, Yu-Ming; Wu, Tsung-Han; Li, Tsung-Lin; Hsia, Simon; Chiu, Yi-Han; Wu, Chang-Jer;     Show all 7 Authors
Source:
Nutrients 2019 v.11 no.8
ISSN:
2072-6643
Subject:
adverse effects; angiogenesis; apoptosis; cachexia; cancer therapy; lung neoplasms; lungs; males; metastasis; mice; mortality; neoplasm cells; nutrition; patients; radiotherapy; signal transduction; vascular endothelial growth factors
Abstract:
... Non-small-cell lung cancer (NSCLC) causes high mortality. Radiotherapy is an induction regimen generally applied to patients with NSCLC. In view of therapeutic efficacy, the outcome is not appealing in addition to bringing about unwanted side effects. Total nutrition is a new trend in cancer therapy, which benefits cancer patients under radiotherapy. Male C57BL/6JNarl mice were experimentally divi ...
DOI:
10.3390/nu11081944

3. Evaluation of lanternfish (Benthosema pterotum) hydrolysates as antioxidants against hydrogen peroxide induced oxidative injury

Author:
Chan, Yi-Lin,   et al.   ; Chai, Huey-Jine; Li, Tsung-Lin; Shiau, Chyuan-Yuan; Wu, Chang-Jer;     Show all 5 Authors
Source:
Food research international 2013 v.54 no.2 pp. 1409-1418
ISSN:
0963-9969
Subject:
survival rate; DNA damage; synapse; gastrointestinal system; hydrogen peroxide; oligopeptides; hydrolysates; iron; proteinases; digestion; toxicity testing; value added; fish; protein hydrolysates; neurodegenerative diseases; antioxidant activity; chelation
Abstract:
... Four different lanternfish (Benthosema pterotum) protein hydrolysates (LPHs) were obtained by treating the fresh whole fish with Protease A, Protease N, Prozyme 6 or Protamex. The Protease-N treated LPHs showed strong antioxidant activities in the assays of DPPH radical scavenging, Fe2+ chelation, reducing power and SOD-like activity. The sequences of two short oligopeptides with highest antioxida ...
DOI:
10.1016/j.foodres.2013.09.052

4. Inhibition of Japanese Encephalitis Virus Infection by the Sulfated Polysaccharide Extracts from Ulva lactuca

Author:
Chan, Yi-Lin,   et al.   ; Chiu, Ya-Huang; Li, Tsung-Lin; Wu, Chang-Jer;     Show all 4 Authors
Source:
Marine biotechnology 2012 v.14 no.4 pp. 468-478
ISSN:
1436-2228
Subject:
Japanese encephalitis virus; Ulva lactuca; adsorption; cytokines; death; drugs; encephalitis; humans; mice; paralysis; viruses
Abstract:
... Japanese encephalitis virus (JEV), a neurotropic flavivirus, is one of the major causes of acute encephalitis in humans. After infection, inflammatory reactions and neurological diseases often develop. Still there are no effective drugs available against virus infection. Recently, extracts of algae have been shown to possess a broad range of biological activities including antivirus activity. In t ...
DOI:
10.1007/s10126-011-9428-x
PubMed:
22193590

5. A cancer vaccine based on the marine antimicrobial peptide pardaxin (GE33) for control of bladder-associated tumors

Author:
Chan, Yi-Lin,   et al.   ; Huang, Han-Ning; Rajanbabu, Venugopal; Pan, Chieh-Yu; Wu, Chang-Jer; Chen, Jyh-Yih;     Show all 6 Authors
Source:
Biomaterials 2013 v.34 no.38 pp. 10151-10159
ISSN:
0142-9612
Subject:
CD4-positive T-lymphocytes; anticarcinogenic activity; antigens; antimicrobial peptides; bladder; carcinoma; cytotoxicity; immunity; immunization; interleukin-12; interleukin-6; mice; monocytes; natural killer cells; neoplasm cells; nitric oxide; nitrous oxide; receptors; secretion; vaccines; vascular endothelial growth factors
Abstract:
... The marine antimicrobial peptide (AMP) GE33, also known as pardaxin, possesses antimicrobial and anticancer properties, and modulates host signaling. GE33 has cytotoxic effects on murine bladder carcinoma (MBT-2) cells. Here, we investigated the potential of GE33 combined with inactivated MBT-2 as a cancer vaccine. The presence of up to 12.5 μg of GE33 did not inhibit the proliferation or endogeno ...
DOI:
10.1016/j.biomaterials.2013.09.041

6. Use of the antimicrobial peptide Epinecidin-1 to protect against MRSA infection in mice with skin injuries

Author:
Chan, Yi-Lin,   et al.   ; Huang, Han-Ning; Rajanbabu, Venugopal; Pan, Chieh-Yu; Wu, Chang-Jer; Chen, Jyh-Yih;     Show all 6 Authors
Source:
Biomaterials 2013 v.34 no.38 pp. 10319-10327
ISSN:
0142-9612
Subject:
Staphylococcus aureus; angiogenesis; anti-infective properties; antibiotic resistance; antimicrobial peptides; blood serum; collagen; interleukin-6; lethal dose; lymphocytes; methicillin; mice; monocytes; plate count; tumor necrosis factor-alpha; vancomycin
Abstract:
... Methicillin-resistant Staphylococcus aureus (MRSA) causes infections through open skin injuries, and its resistance makes treatment difficult. The antimicrobial peptide Epinecidin-1 (Epi-1) has been reported to possess antibacterial, antifungal, antiviral, and antitumor functions. This study investigated the antimicrobial activity of Epi-1 against skin trauma-mediated MRSA infection in mice. One s ...
DOI:
10.1016/j.biomaterials.2013.09.037

7. Passive immune-protection of small abalone against Vibrio alginolyticus infection by anti-Vibrio IgY-encapsulated feed

Author:
Chan, Yi-Lin,   et al.   ; Wu, Chang-Jer; Wang, Hang; Li, Tsung-Lin;     Show all 4 Authors
Source:
Fish & shellfish immunology 2011 v.30 no.4-5 pp. 1042-1048
ISSN:
1050-4648
Subject:
Haliotis diversicolor supertexta; Vibrio alginolyticus; abalone; antibodies; death; diet; eggs; encapsulation; enzymes; financial economics; gastrointestinal system; immunoglobulin Y; mollusc culture; passive immunity; powders; shellfish; survival rate; value added
Abstract:
... Small abalone (Haliotis diversicolor supertexta) is a high value-added shellfish. It however has been suffering Vibrio alginolyticus infections, which cause mass death of small abalone and thus great economic losses, particularly in artificial aquaculture. In this study, we attempted to treat small abalone with anti-Vibrio IgY to elicit a passive immunity directly against V. alginolyticus infectio ...
DOI:
10.1016/j.fsi.2011.01.026

8. Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5

Author:
Chan, Yi-Lin,   et al.   ; Huang, Han-Ning; Rajanbabu, Venugopal; Pan, Chieh-Yu; Hui, Cho-Fat; Chen, Jyh-Yih; Wu, Chang-Jer;     Show all 7 Authors
Source:
Biomaterials 2011 v.32 no.28 pp. 6804-6814
ISSN:
0142-9612
Subject:
Japanese encephalitis virus; Toll-like receptors; adaptive immunity; anti-inflammatory activity; antibodies; antiviral agents; blood serum; brain; caspase-4; chemoattractants; death; encephalitis; genes; hepcidin; humans; immunomodulation; in vitro studies; inflammation; interferon-gamma; interleukin-10; interleukin-12; interleukin-2; interleukin-4; interleukin-5; interleukin-6; mice; microarray technology; monocytes; neuroprotective effect; transcription (genetics); translation (genetics); tumor necrosis factors; viral load; virus replication
Abstract:
... Japanese encephalitis virus (JEV), a neurotropic flavivirus, is one of the major causes of acute encephalitis in humans. After infection, it is commonly associated with inflammatory reactions and neurological disease. There is still no effective antiviral drug available against Japanese encephalitis virus infection. Recently, a number of investigators found that antimicrobial peptide (AMPs) presen ...
DOI:
10.1016/j.biomaterials.2011.05.053

9. Modulation of immune responses by the antimicrobial peptide, epinecidin (Epi)-1, and establishment of an Epi-1-based inactivated vaccine

Author:
Chan, Yi-Lin,   et al.   ; Huang, Han-Ning; Pan, Chieh-Yu; Rajanbabu, Venugopal; Wu, Chang-Jer; Chen, Jyh-Yih;     Show all 6 Authors
Source:
Biomaterials 2011 v.32 no.14 pp. 3627-3636
ISSN:
0142-9612
Subject:
Japanese encephalitis virus; antibodies; antimicrobial peptides; blood serum; brain; cell viability; genes; guidelines; immune response; interferon-gamma; interleukin-10; interleukin-12; mice; models; necrosis; tumor necrosis factor-alpha; vaccines; viruses
Abstract:
... Current efforts to improve the effectiveness of vaccines include incorporating antimicrobial peptides mixed with a virus. The antimicrobial peptide, epinecidin (Epi)-1, was reported to have an antiviral function, and an Epi-1-based inactivated vaccine was postulated as a model and discussed. In this report, we demonstrated modulation of immune responses by Epi-1 and an Epi-1-based Japanese encepha ...
DOI:
10.1016/j.biomaterials.2011.01.061

10. Composition characterization of Myctophids (Benthosema pterotum): Antioxidation and safety evaluations for Myctophids protein hydrolysates

Author:
Chan, Yi-Lin,   et al.   ; Chai, Huey-Jine; Li, Tsung-Lin; Chen, Yu-Chen; Wu, Chwen-Herng; Shiau, Chyuan-Yuan; Wu, Chang-Jer;     Show all 7 Authors
Source:
Food research international 2012 v.46 no.1 pp. 118-126
ISSN:
0963-9969
Subject:
Salmonella Typhimurium; raw materials; no observed adverse effect level; nitrogen compounds; hematology; ophthalmology; marine fish; nitrogen content; EDTA (chelating agent); acute toxicity; protein sources; body weight; superoxide dismutase; models; rats; food safety; Ames test; hydrolysates; ascorbic acid; free radicals; free amino acids; mutagenicity; protein hydrolysates; minerals; polyunsaturated fatty acids
Abstract:
... Myctophids (Benthosema pterotum) were regarded as low-valued small deep-sea fishes. In this study, we however identified that B. pterotum contains high levels of proteins, free amino acids and some functional components (e.g. phospholipids, polyunsaturated fatty acids and minerals). Converting Myctophids from a low-valued fish to a high value-added protein source was thus attempted. The content of ...
DOI:
10.1016/j.foodres.2011.12.008

11. Inhibition of Lipopolysaccharide (LPS)-Induced Inflammatory Responses by Sargassum hemiphyllum Sulfated Polysaccharide Extract in RAW 264.7 Macrophage Cells

Author:
Chan, Yi-Lin,   et al.   ; Hwang, Pai-An; Chien, Shih-Yung; Lu, Mei-Kuang; Wu, Chwen-Herng; Kong, Zwe-Ling; Wu, Chang-Jer;     Show all 7 Authors
Source:
Journal of agricultural and food chemistry 2011 v.59 no.5 pp. 2062-2068
ISSN:
0021-8561
Subject:
Oriental traditional medicine; Sargassum; Western blotting; anti-inflammatory activity; coasts; gene expression; inflammation; interleukin-1; interleukin-6; lipopolysaccharides; macroalgae; macrophages; messenger RNA; mice; nitric oxide; reverse transcriptase polymerase chain reaction; tumor necrosis factor-alpha; East Asia
Abstract:
... Sargassum hemiphyllum, a kind of brown seaweed generally found along coastlines in East Asia, has long served as a traditional Chinese medicine. S. hemiphyllum has shown an anti-inflammatory effect; however, its mechanism has not been elucidated clearly. This study explored S. hemiphyllum for its biomedical effects. S. hemiphyllum sulfated polysaccharide extract (SHSP) was first prepared; the mous ...
DOI:
10.1021/jf1043647
PubMed:
21322561