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- Chang, Donald C., et al. Show all 5 Authors
- Biochemical and biophysical research communications 2014 v.451 pp. 322-328
- apoptosis; calcium; mitochondria; neutralization; precipitin tests; proteins; ruthenium red; screening; small interfering RNA; two hybrid system techniques
- ... Mcl-1 is a major anti-apoptotic Bcl-2 family protein. It is well known that Mcl-1 can interact with certain pro-apoptotic Bcl-2 family proteins in normal cells to neutralize their pro-apoptotic functions, thus prevent apoptosis. In addition, it was recently found that Mcl-1 can also inhibit mitochondrial calcium uptake. The detailed mechanism, however, is still not clear. Based on Yeast Two-Hybrid ...
- Chang, Donald C., et al. Show all 6 Authors
- Nucleic acids research 2011 v.39 no.3 pp. 1054-1065
- RNA interference; cell differentiation; epigenetics; hair follicles; humans; microRNA; somatic cells; stem cells; zygote
- ... Global demethylation is required for early zygote development to establish stem cell pluripotency, yet our findings reiterate this epigenetic reprogramming event in somatic cells through ectopic introduction of mir-302 function. Here, we report that induced mir-302 expression beyond 1.3-fold of the concentration in human embryonic stem (hES) H1 and H9 cells led to reprogramming of human hair folli ...
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- Chang, Donald C., et al. Show all 10 Authors
- Journal of agricultural and food chemistry 2008 v.56 no.23 pp. 11144-11150
- benzophenones; pericarp; xanthone; uterine cervical neoplasms; bioassays; Garcinia; mass spectrometry; cell lines; liquid chromatography; chemical structure; apoptosis; anticarcinogenic activity
- ... Bioassay and ultraperformance liquid chromatography/photodiode array/mass spectrometry (UPLC/PDA/MS) guided isolation of the apoptosis-inducing active metabolites on HeLa-C3 cells from the pericarp of Garcinia yunnanensis (Guttiferae) yielded five active compounds, including the new garciyunnanins A (1) and B (2). The structures of the compounds were elucidated by comprehensive nuclear magnetic re ...