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- Chang, En Hyung, et al. Show all 4 Authors
- Biochimica et biophysica acta 2019 v.1863 no.1 pp. 191-198
- Actinobacillus actinomycetemcomitans; antibacterial properties; bacteria; bacterial toxins; catechin; cholesterol; circular dichroism spectroscopy; confocal microscopy; cytotoxicity; fluorescence; humans; leaves; leukocytes; leukotoxins; mechanism of action; polyphenols; staining; tea; virulence
- ... Catechins, polyphenols derived from tea leaves, have been shown to have antibacterial properties, through direct killing of bacteria as well as through inhibition of bacterial toxin activity. In particular, certain catechins have been shown to have bactericidal effects on the oral bacterium, Aggregatibacter actinomycetemcomitans, as well as the ability to inhibit a key virulence factor of this org ...
- Chang, En Hyung, et al. Show all 5 Authors
- Biochemistry 2016 v.55 no.34 pp. 4787-4797
- amino acids; bacteria; bacterial toxins; cell membranes; cholesterol; leukotoxins; pathogenesis; pathogens; viruses
- ... Recognition of and binding to cholesterol on the host cell membrane is an initial step in the mechanism of numerous pathogens, including viruses, bacteria, and bacterial toxins; however, a viable method of inhibiting this interaction has not yet been uncovered. Here, we describe the mechanism by which a cholesterol recognition amino acid consensus peptide interacts with cholesterol and inhibits th ...
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