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1. Acetylcholine Esterase Antibodies on BiOI Nanoflakes/TiO2 Nanoparticles Electrode: A Case of Application for General Photoelectrochemical Enzymatic Analysis

Author:
Chen, Hong-Yuan,   et al.   ; Zhao, Wei-Wei; Shan, Shu; Ma, Zheng-Yuan; Wan, Lin-Na; Xu, Jing-Juan;     Show all 6 Authors
Source:
Analytical chemistry 2013 v.85 no.24 pp. 11686-11690
ISSN:
1520-6882
Subject:
acetylcholinesterase; antibodies; biosensors; electrodes; enzyme inhibition; nanoparticles
Abstract:
... To date, almost all the established photoelectrochemical (PEC) enzymatic biosensors require the surface-confinement procedure to immobilize enzyme as biorecogniton element for probing various analytes of interest. This Letter develops a novel example without such necessity. Specifically, we first prepared a BiOI nanoflakes (NFs)/TiO₂ nanoparticles (NPs) p–n heterojunction as the photoelectrode, on ...
DOI:
10.1021/ac403691a

2. A colorimetric/fluorescent dual-mode sensor for ultra-sensitive detection of Hg2+

Author:
Chen, Hong-Yuan,   et al.   ; Yu, Tao; Zhang, Ting-Ting; Zhao, Wei; Xu, Jing-Juan;     Show all 5 Authors
Source:
Talanta 2017 v.165 pp. 570-576
ISSN:
0039-9140
Subject:
aqueous solutions; color; colorimetry; detection limit; fluorescence; industrial effluents; lakes; mercury; metal ions; nanogold; polymers; single-stranded DNA
Abstract:
... A highly sensitive colorimetric/fluorescent dual-mode sensor based on hybridization chain reaction (HCR) combining multifunctional Au NPs is presented for the detection of Hg2+ in aqueous solution. In Hg2+ absent solution, the surface of Au NPs was covered by hairpin auxiliary DNAs and a single strand DNA (ssDNA), which prevented Au NPs from salt-induced aggregation. At the same time, the fluoresc ...
DOI:
10.1016/j.talanta.2017.01.026

3. Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly

Author:
Chen, Hong-Yuan,   et al.   ; Yan, Runqi; Hu, Yuxuan; Liu, Fei; Wei, Shixuan; Fang, Daqing; Shuhendler, Adam J.; Liu, Hong; Ye, Deju;     Show all 9 Authors
Source:
Journal of the American Chemical Society 2019 v.141 no.26 pp. 10331-10341
ISSN:
1520-5126
Subject:
alkaline phosphatase; cell membranes; cryo-electron microscopy; enzyme activity; fluorescence; image analysis; liver neoplasms; magnetic resonance imaging; magnetism; mice; models; nanoparticles; near-infrared spectroscopy; neoplasm cells; resection; scanning electron microscopy; tissue engineering; tissues
Abstract:
... Stimuli-responsive in situ self-assembly of small molecules to form nanostructures in living subjects has produced promising tools for molecular imaging and tissue engineering. However, controlling the self-assembly process to simultaneously activate multimodality imaging signals in a small-molecule probe is challenging. In this paper, we rationally integrate a fluorogenic reaction into enzyme-res ...
DOI:
10.1021/jacs.9b03649

4. Activatable QD-Based Near-Infrared Fluorescence Probe for Sensitive Detection and Imaging of DNA

Author:
Chen, Hong-Yuan,   et al.   ; Shen, Yizhong; Zhang, Nan; Sun, Yidan; Zhao, Wei-Wei; Ye, Deju; Xu, Jing-Juan;     Show all 7 Authors
Source:
ACS applied materials & interfaces 2017 v.9 no.30 pp. 25107-25113
ISSN:
1944-8252
Subject:
DNA; aluminum; aqueous solutions; binding capacity; dissociation; electron transfer; fluorescence; fluorescent dyes; image analysis; near-infrared spectroscopy; quantum dots
Abstract:
... Accurate detection of DNA is essential for the precise diagnosis of diseases. Here we report an activatable near-infrared (NIR) fluorescence nanoprobe (QD-Al-GFLX) composed of NIR quantum dots (QDs) and Al(III)-gatifloxacin (Al-GFLX) complexes for the sensitive detection of double-stranded DNA (dsDNA) both in aqueous solution and in living cells. We demonstrated that the initial strong NIR fluores ...
DOI:
10.1021/acsami.7b05871

5. Adjusting the Linear Range of Au-MOF Fluorescent Probes for Real-Time Analyzing Intracellular GSH in Living Cells

Author:
Chen, Hong-Yuan,   et al.   ; Du, Tianyu; Zhang, Hang; Ruan, Jun; Jiang, Hui; Wang, Xuemei;     Show all 6 Authors
Source:
ACS applied materials & interfaces 2018 v.10 no.15 pp. 12417-12423
ISSN:
1944-8252
Subject:
coordination polymers; fluorescein; fluorescence; glutathione; gold; nanogold; neoplasm cells; neoplasms; quantitative analysis
Abstract:
... A series of Au-loaded metal–organic frameworks (MOFs) were synthesized in this study and further employed for real-time quantitative analysis of intracellular glutathione (GSH) level. Different linear ranges can be acquired by altering the size of gold and MOF particles, or adjusting the proportion of 2-aminoterephthalic acid/1,4-benzenedicarboxylate linkers, which is also observed on fluorescein ...
DOI:
10.1021/acsami.7b19356

6. A General Strategy for Photoelectrochemical Immunoassay Using an Enzyme Label Combined with a CdS Quantum Dot/TiO2 Nanoparticle Composite Electrode

Author:
Chen, Hong-Yuan,   et al.   ; Zhao, Wei-Wei; Chen, Ru; Dai, Pan-Pan; Li, Xiang-Ling; Xu, Jing-Juan;     Show all 6 Authors
Source:
Analytical chemistry 2014 v.86 no.23 pp. 11513-11516
ISSN:
1520-6882
Subject:
beta-galactosidase; electrodes; immunoassays; nanoparticles; pH; quantum dots; troponin T
Abstract:
... Photoelectrochemical (PEC) immunoassay has received increasing attention owing to its good analytical performance and attractive potential for future protein assay. This Letter represents a novel and general strategy for elegant PEC immunoassay of the important cardiac marker troponin T (cTnT) at neutral conditions. Specifically, we first developed an efficient CdS quantum dots (QDs)/TiO₂ nanopart ...
DOI:
10.1021/ac503969e

7. Ag nanoclusters could efficiently quench the photoresponse of CdS quantum dots for novel energy transfer-based photoelectrochemical bioanalysis

Author:
Chen, Hong-Yuan,   et al.   ; Zhang, Ling; Sun, Yue; Liang, Yan-Yu; He, Jian-Ping; Zhao, Wei-Wei; Xu, Jing-Juan;     Show all 7 Authors
Source:
Biosensors & bioelectronics 2016 v.85 pp. 930-934
ISSN:
0956-5663
Subject:
DNA; biosensors; detection limit; electrodes; encapsulation; energy transfer; monitoring; nanoparticles; nucleotide sequences; oligonucleotides; quantum dots; silver
Abstract:
... Herein the influence of ultrasmall Ag nanoclusters (Ag NCs) against CdS quantum dots (QDs) in a photoelectrochemical (PEC) nanosystem was exploited for the first time, based on which a novel PEC bioanalysis was successfully developed via the efficient quenching effect of Ag NCs against the CdS QDs. In a model system, DNA assay was achieved by using molecular beacon (MB) probes anchored on a CdS QD ...
DOI:
10.1016/j.bios.2016.06.018

8. Alkaline Phosphatase Tagged Antibodies on Gold Nanoparticles/TiO2 Nanotubes Electrode: A Plasmonic Strategy for Label-Free and Amplified Photoelectrochemical Immunoassay

Author:
Chen, Hong-Yuan,   et al.   ; Zhu, Yuan-Cheng; Zhang, Nan; Ruan, Yi-Fan; Zhao, Wei-Wei; Xu, Jing-Juan;     Show all 6 Authors
Source:
Analytical chemistry 2016 v.88 no.11 pp. 5626-5630
ISSN:
1520-6882
Subject:
alkaline phosphatase; antibodies; cell cycle; electrodes; gold; immunoassays; monitoring; nanogold; nanotubes; titanium dioxide; transcription factors
Abstract:
... This work reports a plasmonic strategy capable of label-free yet amplified photoelectrochemical (PEC) immunoassay for the sensitive and specific detection of model protein p53, an important transcription factor that regulates the cell cycle and functions as a tumor suppressor. Specifically, on the basis of Au nanoparticles (NPs) deposited on hierarchically ordered TiO₂ nanotubes (NTs), a protein G ...
DOI:
10.1021/acs.analchem.6b01261

9. A microfluidic cigarette smoke collecting platform for simultaneous sample extraction and multiplex analysis

Author:
Chen, Hong-Yuan,   et al.   ; Hu, Shan-Wen; Xu, Bi-Yi; Qiao, Shu; Zhao, Ge; Xu, Jing-Juan; Xie, Fu-Wei;     Show all 7 Authors
Source:
Talanta 2016 v.150 pp. 455-462
ISSN:
0039-9140
Subject:
air; air pollution; breathing; cigarettes; droplets; formaldehyde; hexanoic acid; humans; mass spectrometry; nicotine; pollutants; polydimethylsiloxane; smoke; solvents
Abstract:
... In this work, we report a novel microfluidic gas collecting platform aiming at simultaneous sample extraction and multiplex mass spectrometry (MS) analysis. An alveolar-mimicking elastic polydimethylsiloxane (PDMS) structures was designed to move dynamically driven by external pressure. The movement was well tuned both by its amplitude and rhythm following the natural process of human respiration. ...
DOI:
10.1016/j.talanta.2015.12.052

10. Amperometric monitoring of vesicular dopamine release using a gold nanocone electrode

Author:
Chen, Hong-Yuan,   et al.   ; Zhang, Nan; Zhao, Wei; Xu, Cong-Hui; Xu, Jing-Juan;     Show all 5 Authors
Source:
Chemical communications 2019 v.55 no.24 pp. 3461-3464
ISSN:
1364-548X
Subject:
chemical reactions; dopamine; electrodes; gold; monitoring; nanogold
Abstract:
... We report a facile approach to fabricate a gold nanocone electrode for monitoring dopamine release from individual vesicles. ...
DOI:
10.1039/c9cc01280j

11. Amplified electrochemiluminescence detection of DNA-binding protein based on the synergy effect of electron and energy transfer between CdS nanocrystals and gold nanoparticles

Author:
Chen, Hong-Yuan,   et al.   ; Wang, Jing; Zhao, Wei-Wei; Zhou, Hong; Xu, Jing-Juan;     Show all 5 Authors
Source:
Biosensors & bioelectronics 2013 v.41 pp. 615-620
ISSN:
0956-5663
Subject:
DNA; DNA-binding proteins; biosensors; electrodes; electron transfer; energy transfer; gold; nanocrystals; nanogold
Abstract:
... In this work, we firstly enunciated the presence of synergy effect between the electron and energy transfer in an electrochemiluminescence (ECL) system involving the CdS NCs and Au NPs, based on which an amplified ECL biosensor was constructed for sensitive detection of DNA–protein interactions. Specifically, Au NPs modified on electrode, following by assembled probe DNA. Then the modified GCE was ...
DOI:
10.1016/j.bios.2012.09.041

12. A multifunctional silver nanocomposite for the apoptosis of cancer cells and intracellular imaging

Author:
Chen, Hong-Yuan,   et al.   ; Zhang, Ting-Ting; Yang, Fan; Li, Xiang-ling; Zhao, Wei; Xu, Jing-Juan;     Show all 6 Authors
Source:
Chemical communications 2017 v.53 no.41 pp. 5614-5617
ISSN:
1364-548X
Subject:
apoptosis; image analysis; nanocomposites; nanosilver; neoplasm cells; neoplasms; silver; therapeutics
Abstract:
... A multifunctional Ag NP based nanocomposite was fabricated which realized accurate targeting of specific cancer cells and completely initiative therapy without any photoexcitation. ...
DOI:
10.1039/c7cc02834b

13. Analysis of Intracellular Glucose at Single Cells Using Electrochemiluminescence Imaging

Author:
Chen, Hong-yuan,   et al.   ; Xu, Jingjing; Huang, Peiyuan; Qin, Yu; Jiang, Dechen;     Show all 5 Authors
Source:
Analytical chemistry 2016 v.88 no.9 pp. 4609-4612
ISSN:
1520-6882
Subject:
cell membranes; electrochemiluminescence; glucose; glucose oxidase; gold; hydrogen peroxide; image analysis; indium tin oxide; light intensity; octoxynol; starvation
Abstract:
... Here, luminol electrochemiluminescence was first applied to analyze intracellular molecules, such as glucose, at single cells. The individual cells were retained in cell-sized microwells on a gold coated indium tin oxide (ITO) slide, which were treated with luminol, triton X-100, and glucose oxidase simultaneously. The broken cellular membrane in the presence of triton X-100 released intracellular ...
DOI:
10.1021/acs.analchem.6b01073

14. An off–on–off electrochemiluminescence approach for ultrasensitive detection of thrombin

Author:
Chen, Hong-Yuan,   et al.   ; Deng, Li; Du, Ying; Xu, Jing-Juan;     Show all 4 Authors
Source:
Biosensors & bioelectronics 2014 v.59 pp. 58-63
ISSN:
0956-5663
Subject:
biosensors; complementary DNA; detection limit; electrochemiluminescence; energy transfer; glassy carbon electrode; nanocrystals; nanogold; oligonucleotides; surface plasmon resonance; thrombin
Abstract:
... This work demonstrates an aptasensor for ultrasensitive electrochemiluminescence (ECL) detection of thrombin based on an “off–on–off” approach. The system is composed of an Eu3+-doped CdS nanocrystals (CdS:Eu NCs) film on glassy carbon electrode (GCE) as ECL emitter. Then gold nanoparticles (AuNPs) labeled hairpin-DNA probe (ssDNA1) containing thrombin-binding aptamer (TBA) sequence was linked on ...
DOI:
10.1016/j.bios.2014.03.012

15. A novel aptasensor based on silver nanoparticle enhanced fluorescence

Author:
Chen, Hong-Yuan,   et al.   ; Wang, Ying; Li, Zhonghui; Li, Hui; Vuki, Maika; Xu, Danke;     Show all 6 Authors
Source:
Biosensors & bioelectronics 2012 v.32 no.1 pp. 76-81
ISSN:
0956-5663
Subject:
adenosine; biosensors; correlation; detection limit; fluorescence; fluorescent dyes; nanosilver; oligonucleotides; spatial distribution
Abstract:
... In the present study, we report a novel aptasensor based on silver nanoparticle enhanced fluorescence for the detection of adenosine. First, the distance dependence nature of silver nanoparticle enhanced fluorescence was investigated through fluorescent dyes modified oligonucleotides to control the spacing distance between dyes and AgNP. The results showed that the fluorescence intensity reached t ...
DOI:
10.1016/j.bios.2011.11.030

16. A novel evaluation method for extrapolated retention factor in determination of n-octanol/water partition coefficient of halogenated organic pollutants by reversed-phase high performance liquid chromatography

Author:
Chen, Hong-yuan,   et al.   ; Han, Shu-ying; Liang, Chao; Qiao, Jun-qin; Lian, Hong-zhen; Ge, Xin;     Show all 6 Authors
Source:
Analytica chimica acta 2012 v.713 pp. 130-135
ISSN:
0003-2670
Subject:
benzene; chlorination; hydrophobicity; models; pollutants; polychlorinated biphenyls; reversed-phase high performance liquid chromatography
Abstract:
... The retention factor corresponding to pure water in reversed-phase high performance liquid chromatography (RP-HPLC), kw, was commonly obtained by extrapolation of retention factor (k) in a mixture of organic modifier and water as mobile phase in tedious experiments. In this paper, a relationship between logkw and logk for directly determining kw has been proposed for the first time. With a satisfa ...
DOI:
10.1016/j.aca.2011.11.020

17. A novel lable-free electrochemical immunosensor for carcinoembryonic antigen based on gold nanoparticles–thionine–reduced graphene oxide nanocomposite film modified glassy carbon electrode

Author:
Chen, Hong-Yuan,   et al.   ; Kong, Fen-Ying; Xu, Mao-Tian; Xu, Jing-Juan;     Show all 4 Authors
Source:
Talanta 2011 v.85 no.5 pp. 2620-2625
ISSN:
0039-9140
Subject:
antibodies; antigens; biocompatibility; detection limit; dielectric spectroscopy; electrochemistry; glassy carbon electrode; gold; graphene; immunosensors; nanocomposites; scanning electron microscopy; surface area
Abstract:
... In this paper, gold nanoparticle–thionine–reduced graphene oxide (GNP–THi–GR) nanocomposites were prepared to design a label-free immunosensor for the sensitive detection of carcinoembryonic antigen (CEA). The nanocomposites with good biocompatibility, excellent redox electrochemical activity and large surface area were coated onto the glassy carbon electrode (GCE) surface and then CEA antibody (a ...
DOI:
10.1016/j.talanta.2011.08.028

18. An ultrasensitive energy-transfer based photoelectrochemical protein biosensor

Author:
Chen, Hong-Yuan,   et al.   ; XuThese authors contribute to this work equally., Fei; Zhu, Yuan-Cheng; Ma, Zheng-Yuan; Zhao, Wei-Wei; Xu, Jing-Juan;     Show all 6 Authors
Source:
Chemical communications 2016 v.52 no.14 pp. 3034-3037
ISSN:
1364-548X
Subject:
biosensors; chemical reactions; energy transfer; gold; nanogold; single-stranded DNA
Abstract:
... Using single stranded DNA (ssDNA) as a distance controller and Au nanoparticles (NPs) functionalized with ssDNA as novel energy-transfer nanoprobes, an ultrasensitive energy-transfer based photoelectrochemical protein biosensor was realized. ...
DOI:
10.1039/c5cc09963c

19. A paper-based SERS test strip for quantitative detection of Mucin-1 in whole blood

Author:
Chen, Hong-Yuan,   et al.   ; Hu, Shan-Wen; Qiao, Shu; Pan, Jian-Bin; Kang, Bin; Xu, Jing-Juan;     Show all 6 Authors
Source:
Talanta 2018 v.179 pp. 9-14
ISSN:
0039-9140
Subject:
biosensors; blood; disease detection; nanogold; oligonucleotides; paper; spectroscopy
Abstract:
... A paper-based SERS test strip combining strengths of paper chip and Raman active substrate was demonstrated to overcome challenges in spectroscopic sensing of complicated samples and realize quantitative detection of disease markers in whole blood. The precisely controlled Au NPs were not only capable of generating condensed hot spots on the fibers, but also enhanced the size exclusion effect of p ...
DOI:
10.1016/j.talanta.2017.10.038

20. A PCR-free colorimetric strategy for visualized assay of telomerase activity

Author:
Chen, Hong-Yuan,   et al.   ; Yu, Tao; Zhao, Wei; Xu, Jing-Juan;     Show all 4 Authors
Source:
Talanta 2018 v.178 pp. 594-599
ISSN:
0039-9140
Subject:
DNA; antineoplastic agents; colorimetry; enzyme activity; humans; nanogold; neoplasms; polymerase chain reaction; screening; telomerase
Abstract:
... A simple yet powerful polymerase chain reaction (PCR)-free strategy for visualized assay of human telomerase activity was reported in this work. Gold nanoparticles (AuNPs) based colorimetric strategy was applied with well-designed enzyme-aided cyclic amplification. Briefly, the detection relies on the elongated primers of telomerase substrate (TS) induced by telomerase, which open the hairpin DNA ...
DOI:
10.1016/j.talanta.2017.09.070