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- Chen, Wan-Qing, et al. Show all 7 Authors
- Natural medicines 2019 v.73 no.1 pp. 217-225
- Gelsemium elegans; alkaloids; analgesia; analgesic effect; analgesics; animal models; anti-inflammatory activity; astrocytes; interleukin-1beta; neoplasms; pain; poisonous plants; rats; rheumatoid arthritis; tumor necrosis factor-alpha
- ... Gelsemium elegans Benth. is a toxic plant that has been used as an ancient Chinese herbal remedy for rheumatoid arthritis (RA) and nervous pain, spasticity, skin ulcers, and cancers. Koumine, one of its representative alkaloids, shows numerous promising pharmacological activities, including anti-inflammatory and analgesic activities. Here, we investigated the analgesic effect of koumine on the col ...