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- Chen, Ziteng, et al. Show all 6 Authors
- Biochemical and biophysical research communications 2019 v.513 no.3 pp. 694-700
- binding capacity; binding sites; fibronectins; half life; humans; immunoglobulin G; monoclonal antibodies; peptides; recombinant proteins
- ... A variety of CTLA4-Fc fusion proteins and anti-CTLA4 monoclonal antibody have been approved. Given the shortcomings of macromolecular antibodies, recombinant proteins derived from the tenth unit of human type III fibronectin (FN3) termed monobody were studied as CTLA4 analogs in this study. A peptide EL161 derived from CD80-binding domain (MYPPPY motifs) in the complementarity determining region ( ...