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1. Metabolic changes in urine and serum during progression of diabetic kidney disease in a mouse model

Author:
Cho, Ahreum,   et al.   ; Kim, Nan Hee; Hyeon, Jin Seong; Kim, Nam Hoon; Lee, Gayoung; Jang, Seo Young; Kim, Mi-Kyung; Lee, Eun Young; Chung, Choon Hee; Ha, Hunjoo; Hwang, Geum Sook;     Show all 11 Authors
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 90-97
ISSN:
0003-9861
Subject:
albumins; animal models; biomarkers; blood serum; early diagnosis; excretion; fatty acid metabolism; glucose; kidney diseases; metabolites; metabolomics; mice; nuclear magnetic resonance spectroscopy; pathophysiology; tricarboxylic acid cycle; urine
Abstract:
... Diabetic kidney disease (DKD) involves various pathogenic processes during progression to end stage renal disease, and activated metabolic pathways might be changing based on major pathophysiologic mechanisms as DKD progresses. In this study, nuclear magnetic resonance spectroscopy (NMR)-based metabolic profiling was performed in db/db mice to suggest potential biomarkers for early detection and i ...
DOI:
10.1016/j.abb.2018.03.042