Jump to Main Content
- Choi, Jong-Moon, et al. Show all 4 Authors
- Archives of pharmacal research 2006 v.29 no.4 pp. 323-327
- bile salts; cations; hepatocytes; intrahepatic cholestasis; intravenous injection; liver; pharmacokinetics; rats; tritium
- ... The objective of this study was to examine the pharmacokinetics of organic cations in intrahepatic cholestatic rats. A pretreatment with 17α-ethynylestradiol was used to induce intrahepatic cholestasis, and tributylmethylammonium (TBuMA) was used as a representative model organic cation. When [³H]TBuMA was intravenously administered, the AUC value for TBuMA was significantly increased by 79% in ch ...