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- Author:
- Christina Tam, et al. ; Ling Chen; Wallace Yokoyama; Yuqing Tan; Pricilla Alves; Glenn Bartley; Fang Zhong; Show all 7 Authors
- Source:
- Journal of agricultural and food chemistry 2021 v.69 no.32 pp. 9383-9394
- ISSN:
- 1520-5118
- Subject:
- absorption; bioavailability; digestion; food chemistry; human cell lines; lipophilicity; metabolism; micelles; nanocarriers; retinoids; retinyl palmitate; transportation; whey protein
- Abstract:
- ... Three protein emulsifiers encapsulating β-carotene (BC) with accompanying lipids into nanoemulsions (NEs) or without lipids into nanoparticles (NPs) were fabricated to study the effect of the type of interfacial protein on carrier design and the structure remodeling during digestion on the overall uptake and metabolism of BC in Caco-2 cells. BC-loaded micelles and micellar-like aggregates were col ...
- DOI:
- 10.1021/acs.jafc.1c02431
- https://doi.org/10.1021/acs.jafc.1c02431
- Author:
- Christina Tam, et al. ; Ling Chen; Wallace Yokoyama; Rong Liang; Jackie Miller; Fang Zhong; Show all 6 Authors
- Source:
- Journal of agricultural and food chemistry 2020 v.68 no.52 pp. 15468-15477
- ISSN:
- 1520-5118
- Subject:
- Fourier transform infrared spectroscopy; absorption; adsorption; bile; digestion; food chemistry; hydrolysis; intestinal secretions; microstructure; surface proteins
- Abstract:
- ... The remodeling of β-carotene-encapsulated protein nanoparticles (NPs) during digestion in vitro and in vivo was investigated. The NPs were formed using three different proteins. Hydrolysis of the surface protein during digestion resulted in structure remodeling of NPs and the formation of small-sized micellar-like aggregates below 100 nm, accelerating the release of β-carotene into the aqueous pha ...
- DOI:
- 10.1021/acs.jafc.0c05322
- https://doi.org/10.1021/acs.jafc.0c05322
- Author:
- Christina Tam, et al. ; Sandy Thai; Roberto J. Avena-Bustillos; Priscila Alves; James Pan; Alex Osorio-Ruiz; Jackie Miller; Matthew R. Rolston; Eli Teran-Cabanillas; Wallace H. Yokoyama; Tara H. McHugh; Show all 11 Authors
- Source:
- Applied food research 2022 v.2 no.1 pp. 100052
- ISSN:
- 2772-5022
- Subject:
- Bacteroidetes; Firmicutes; antioxidant activity; blood plasma; cholesterol; dietary fiber; dose response; feed intake; food research; ghrelin; humans; kidneys; leptin; liver; metabolic syndrome; microorganisms; phenolic compounds; proximate composition; spent grains; water activity; white adipose tissue
- Abstract:
- ... Brewer's spent grain (BSG) was dried via infra-red drying (IRD) or hot-air drying (HAD) and milled into fine powders. Proximate analysis (moisture, protein, fat, ash, carbohydrates by difference), water activity, dietary fiber, total soluble phenolics, and antioxidant capacity analyses were performed to characterize and compare both types of BSG powders. Mice feeding of the two types of dried BSG, ...
- DOI:
- 10.1016/j.afres.2022.100052
- CHORUS:
- 10.1016/j.afres.2022.100052
- https://doi.org/10.1016/j.afres.2022.100052
- Author:
- Christina Tam, et al. ; Prinessa Chellan; Tameryn Stringer; Ajit Shokar; Aaron Au; Luisa W. Cheng; Gregory S. Smith; Kirkwood M. Land; Show all 8 Authors
- Source:
- Inorganic Chemistry Communications 2019 v.102 no. pp. 1-4
- ISSN:
- 1387-7003
- Subject:
- Trichomonas vaginalis; antiprotozoal properties; chemistry; flora; mammals; metronidazole; palladium; parasites; patients
- Abstract:
- ... Clinical cases of metronidazole resistant Trichomonas vaginalis infections have spurred interest in drug discovery against this protozoal parasite. We have carried out structure-activity studies using mononuclear palladium(II) complexes containing salicylaldiminato thiosemicarbazones on a patient isolate of Trichomonas vaginalis highly resistant to the FDA-approved drug metronidazole. A small libr ...
- Handle:
- 10113/7325760
- DOI:
- 10.1016/j.inoche.2019.01.033
- CHORUS:
- 10.1016/j.inoche.2019.01.033
- https://doi.org/10.1016/j.inoche.2019.01.033
- Author:
- Christina Tam, et al. ; Amandeep Singh; Grant Fong; Jenny Liu; Yun-Hsuan Wu; Kevin Chang; William Park; Jihwan Kim; Luisa Cheng; Kirkwood Land; Vipan Kumar; Show all 11 Authors
- Source:
- ACS omega 2018 v.3 no.5 pp. 5808-5813
- ISSN:
- 2470-1343
- Subject:
- Trichomonas vaginalis; antiprotozoal properties; chalcone; ferrocenes; indoles; inhibitory concentration 50; microbiome; synthesis; triazoles; trichomoniasis
- Abstract:
- ... In this study, we outline the synthesis of isatin–ferrocenyl chalcone and 1H-1,2,3-triazole-tethered isatin–ferrocene conjugates along with their antimicrobial evaluation against the human mucosal pathogen Trichomonas vaginalis. The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhib ...
- Handle:
- 10113/6473320
- DOI:
- 10.1021/acsomega.8b00553
- PubMed:
- 30023926
- PubMed Central:
- PMC6045481
- CHORUS:
- 10.1021/acsomega.8b00553
- Chorus Open Access:
- 10.1021/acsomega.8b00553
- https://doi.org/10.1021/acsomega.8b00553
- Author:
- Christina Tam, et al. ; Mendel Friedman; Vincent Huang; Quincel Quiambao; Sabrina Noritake; Jenny Liu; Ohkun Kwon; Sirisha Chintalapati; Joseph Young; Carol E. Levin; Luisa W. Cheng; Kirkwood M. Land; Show all 12 Authors
- Source:
- Journal of agricultural and food chemistry 2018 v.66 no.30 pp. 7942-7947
- ISSN:
- 1520-5118
- Subject:
- Trichomonas vaginalis; Tritrichomonas foetus; alpha-chaconine; bioactive compounds; cats; cattle; chlorogenic acid; fingerlings; food industry; high performance liquid chromatography; human diseases; microorganisms; parasites; phenolic compounds; potato peels; potatoes; powders; quercetin; solanidine; solanine; therapeutics; trichomoniasis; virulent strains; wastes
- Abstract:
- ... Potato peel, a waste product of the potato processing industry, is high in bioactive compounds. We investigated the in vitro antitrichomonad activity of potato peel powders prepared from commercial Russet, red, purple, and fingerling varieties as well as several known potato components, alkaloids and phenolic compounds, against three pathogenic strains of trichomonads. Trichomonas vaginalis is a s ...
- DOI:
- 10.1021/acs.jafc.8b01726
- CHORUS:
- 10.1021/acs.jafc.8b01726
- https://doi.org/10.1021/acs.jafc.8b01726
- Author:
- Christina Tam, et al. ; Prinessa Chellan; Vicky M. Avery; Sandra Duffy; James A. Triccas; Gayathri Nagalingam; Luisa W. Cheng; Jenny Liu; Kirkwood M. Land; Guy J. Clarkson; Isolda Romero-Canelón; Peter J. Sadler; Show all 12 Authors
- Source:
- Chemistry - a European journal 2018 v.24 no.40 pp. 10078-10090
- ISSN:
- 0947-6539
- Subject:
- Mycobacterium tuberculosis; Plasmodium falciparum; Trichomonas vaginalis; antibacterial properties; antibiotic resistance; antiplasmodial properties; aromatic compounds; chloroquine; coordination compounds; gametocytes; hydrophobicity; imines; inhibitory concentration 50; iridium; organometallic compounds; rhodium; ruthenium; sulfadoxine
- Abstract:
- ... Fourteen novel arene RuII, and cyclopentadienyl (Cpx) RhIII and IrIII complexes containing an N,N’-chelated pyridylimino- or quinolylimino ligand functionalized with the antimalarial drug sulfadoxine have been synthesized and characterized, including three by X-ray crystallography. The rhodium and iridium complexes exhibited potent antiplasmodial activity with IC50 values of 0.10–2.0 mm in either ...
- Handle:
- 10113/6764840
- DOI:
- 10.1002/chem.201801090
- https://doi.org/10.1002/chem.201801090
- Author:
- Christina Tam, et al. ; Sabrina M. Noritake; Jenny Liu; Sierra Kanetake; Carol E. Levin; Luisa W. Cheng; Kirkwood M. Land; Mendel Friedman; Show all 8 Authors
- Source:
- BMC complementary and alternative medicine 2017 v.17 no.1 pp. 461
- ISSN:
- 1472-6882
- Subject:
- Trichomonas vaginalis; Tritrichomonas foetus; Ziziphus; alternative medicine; bacteria; bioactive properties; black tea; cats; cattle; flora; foods; grape seeds; grapes; green tea; high performance liquid chromatography; humans; pathogens; phytopharmaceuticals; pomegranates; secondary metabolites; theaflavins; trichomoniasis
- Abstract:
- ... BACKGROUND: Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were active against pathogenic foodborne bacteria. Trichomonads produce disease (trichomoniasis) in humans and in certain animals. Trichomonads are increasingly becoming resistant to conv ...
- DOI:
- 10.1186/s12906-017-1967-x
- PubMed:
- 28903731
- PubMed Central:
- PMC5598040
- https://doi.org/10.1186/s12906-017-1967-x
- Author:
- Christina Tam, et al. ; Owen Demke; Timothy Hermanas; Anthony Mitchell; Antoni P. A. Hendrickx; Olaf Schneewind; Show all 6 Authors
- Source:
- Journal of bacteriology 2014 v.196 no.6 pp. 1165-1173
- ISSN:
- 0021-9193
- Subject:
- Ctenocephalides felis; Yersinia pestis; bacteriology; biofilm; cats; foregut; hosts; humans; mutants; plague; rats; transcription factors; transposons
- Abstract:
- ... For transmission to new hosts, Yersinia pestis, the causative agent of plague, replicates as biofilm in the foregut of fleas that feed on plague-infected animals or humans. Y. pestis biofilm formation has been studied in the rat flea; however, little is known about the cat flea, a species that may bridge zoonotic and anthroponotic plague cycles. Here, we show that Y. pestis infects and replicates ...
- DOI:
- 10.1128/JB.01187-13
- PubMed:
- 24391055
- PubMed Central:
- PMC3957715
- https://doi.org/10.1128/JB.01187-13
10. Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties
- Author:
- Christina Tam, et al. ; Muneebah Adams; Tameryn Stringer; Carmen De Kock; Peter J. Smith; Kirkwood M. Land; Nicole Liu; Luisa W. Cheng; Mathew Njoroge; Kelly Chibale; Gregory S. Smith; Show all 11 Authors
- Source:
- Dalton Trans 2016 v.45 no.47 pp. 19086-19095
- ISSN:
- 1477-9226
- Subject:
- Chinese hamsters; Escherichia coli; Lactobacillus; Plasmodium falciparum; Trichomonas vaginalis; X-ray diffraction; animal ovaries; antimalarials; antiparasitic properties; carbon; cells; chemical structure; cytotoxicity; growth retardation; humans; liver microsomes; microbiome; parasites; pathogens; quinolines; screening; strains
- Abstract:
- ... Bioisosteric ferrocenyl-containing quinolines and ferrocenylamines containing organosilanes and their carbon analogues, were prepared and fully characterised. The molecular structures of two ferrocenyl- containing quinolines, determined using single-crystal X-ray diffraction, revealed that the compounds crystallise in a folded conformation. The compounds were screened for their antiplasmodial acti ...
- Handle:
- 10113/5678136
- DOI:
- 10.1039/C6DT03175G
- https://doi.org/10.1039/C6DT03175G
11. Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics
- Author:
- Christina Tam, et al. ; Tameryn Stringer; Carmen De Kock; Hajira Guzgay; John Okombo; Jenny Liu; Sierra Kanetake; Jihwan Kim; Luisa W. Cheng; Peter J. Smith; Denver T. Hendricks; Kirkwood M. Land; Timothy J. Egan; Gregory S. Smith; Show all 14 Authors
- Source:
- Dalton Transactions 2016 v.45 no.34 pp. 13415-13426
- ISSN:
- 1477-9226
- Subject:
- Plasmodium falciparum; Trichomonas vaginalis; X-ray diffraction; antiparasitic properties; bacteria; cell lines; chemical structure; chloroquine; cytotoxicity; esophagus; in vitro studies; neoplasm cells; neoplasms; parasites; pathogens; polyamines; quinoline; screening
- Abstract:
- ... A series of mono- and multimeric polyamine-containing ferrocenyl complexes containing a quinoline motif were prepared. The complexes were characterised by standard techniques. The molecular structure of the monomeric salicylaldimine derivative was elucidated using single crystal X-ray diffraction and was consistent with the proposed structure. The antiplasmodial activity of the compounds were eval ...
- Handle:
- 10113/63169
- DOI:
- 10.1039/C6DT02685K
- https://doi.org/10.1039/C6DT02685K