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1. N-terminus of Classical swine fever virus strain TD96 glycoprotein Erns contains a potential heparin-binding domain

Author:
Cheng, Chih-Yuan; Wu, Ching-Wei; Chien, Maw-Sheng; Huang, Chienjin
Source:
Veterinary microbiology 2019 v.232 pp. 79-83
ISSN:
0378-1135
Subject:
Classical swine fever virus,   etc   ; Pichia pastoris; amino acids; genes; glycoproteins; heparin; recombinant proteins; sequence analysis; site-directed mutagenesis; viruses; yeasts;     Show all 11 Subjects
Abstract:
... Classical swine fever virus (CSFV) envelope glycoprotein Erns has been shown to bind to cell surface sulphated-heparin-like glycosaminoglycans (GAGs), which participate in cell attachment of the virus. In this study, the CSFV Erns gene was codon optimized for expression in the yeast Pichia pastoris. A C-terminally truncated Erns recombinant protein lacking the previously identified heparin-binding ...
DOI:
10.1016/j.vetmic.2019.03.029

2. Co-infection status of classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circoviruses (PCV2 and PCV3) in eight regions of China from 2016 to 2018

Author:
Chen, Nanhua; Huang, Yucheng; Ye, Mengxue; Li, Shuai; Xiao, Yanzhao; Cui, Bailei; Zhu, Jianzhong
Source:
Infection, genetics, and evolution 2019 v.68 pp. 127-135
ISSN:
1567-1348
Subject:
Classical swine fever virus,   etc   ; Circoviridae; Porcine reproductive and respiratory syndrome virus; epidemiology; herds; mixed infection; phylogeny; swine; viruses; China;     Show all 10 Subjects
Abstract:
... Classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circoviruses (PCV2 and PCV3) are economically important swine viruses that cause reproductive failure and/or respiratory symptoms in pigs. However, the co-infection status of these viruses in Chinese swine herds is not well clarified. In this study, we evaluated the co-infection of these fou ...
DOI:
10.1016/j.meegid.2018.12.011

3. Assessment of the efficacy of an attenuated live marker classical swine fever vaccine (Flc-LOM-BErns) in pregnant sows

Author:
Lim, Seong-in; Choe, SeEun; Kim, Ki-Sun; Jeoung, Hye-Young; Cha, Ra Mi; Park, Gil-Soon; Shin, Jihye; Park, Gyu-Nam; Cho, In-Soo; Song, Jae-Young; Hyun, Bang-Hun; Park, Bong-Kyun; An, Dong-Jun
Source:
Vaccine 2019 v.37 no.27 pp. 3598-3604
ISSN:
0264-410X
Subject:
Classical swine fever virus,   etc   ; Bovine viral diarrhea virus; antibodies; capsid; fetus; genes; hog cholera; insemination; nucleotide sequences; piglets; pregnancy; sows; transplacental transmission; vaccines; virulence; viruses;     Show all 16 Subjects
Abstract:
... Here, we constructed an attenuated live marker classical swine fever (CSF) vaccine (Flc-LOM-BErns) to eradicate CSF. This was done by taking infectious clone Flc-LOM, which is based on an attenuated live CSF vaccine virus (LOM strain), and removing the full-length classical swine fever virus (CSFV) Erns sequences and the 3′ end (52 base pairs) of the CSFV capsid. These regions were substituted wit ...
DOI:
10.1016/j.vaccine.2019.04.076

4. Complete genome sequences of two strains of classical swine fever virus of subgenotype 2.3 detected during outbreaks in 2005 and 2006 in Serbia

Author:
Petrović, Tamaš; Kuhar, Urška; Lazić, Sava; Prodanov-Radulović, Jasna; Lupulović, Diana; Lazić, Gospava; Toplak, Ivan
Source:
Archives of virology 2019 v.164 no.2 pp. 629-631
ISSN:
0304-8608
Subject:
Classical swine fever virus,   etc   ; genome; high-throughput nucleotide sequencing; kidney cells; nucleotide sequences; phylogeny; signs and symptoms (animals and humans); subgenotype; swine; Balkans; Serbia;     Show all 11 Subjects
Abstract:
... Two strains of classical swine fever virus (CSFV) (SRB/CSFV/1264/2005 and SRB/CSFV/6168/2006), producing serious clinical signs of disease during outbreaks in 2005 and 2006 in Serbia, were isolated on porcine kidney cells, and their complete genomes were determined by next-generation sequencing. This first complete genome characterization of Serbian CSFV strains provides new data about the evoluti ...
DOI:
10.1007/s00705-018-4085-2

5. Expression and purification of classical swine fever virus E2 protein from Sf9 cells using a modified vector

Author:
Yang, Ling; Lu, Xingmeng; Fang, Weihuan
Source:
Biotechnology letters 2017 v.39 no.12 pp. 1821-1825
ISSN:
0141-5492
Subject:
Classical swine fever virus,   etc   ; genes; melittin; polyacrylamide gel electrophoresis; proteins;     Show all 5 Subjects
Abstract:
... OBJECTIVE: To develop a simple method for efficient expression of classical swine fever virus (CSFV) E2 protein. RESULTS: The pFastBac HT B vector (pFastHTB-M1) was modified by adding a melittin signal peptide sequence. The E2 gene fragment without the transmembrane region was cloned into pFastHTB-M1. The modified vector has clear advantage over the original one, as evidenced by the purified recom ...
DOI:
10.1007/s10529-017-2426-y

6. MAVS induces a host cell defense to inhibit CSFV infection

Author:
Dong, Wang; Lv, Huifang; Li, Cheng; Liu, Yaru; Wang, Chengbao; Lin, Jihui; Wang, Yifan; Qian, Gui; Guo, Kangkang; Zhang, Yanming
Source:
Archives of virology 2018 v.163 no.7 pp. 1805-1821
ISSN:
0304-8608
Subject:
Classical swine fever virus,   etc   ; apoptosis; chronic diseases; cytokines; financial economics; immunomodulators; interferons; macrophages; mitochondria; reactive oxygen species; receptors; swine;     Show all 12 Subjects
Abstract:
... Classical swine fever virus (CSFV) infection results in highly significant economic losses. Previous studies have suggested that CSFV can be recognized by RIG-I-like receptors (RLRs) to trigger innate defenses. However, the role of mitochondrial antiviral signaling protein (MAVS), the adaptor of RLRs, is still unknown during CSFV infection. Here, we showed that CSFV infection increased MAVS expres ...
DOI:
10.1007/s00705-018-3804-z

7. Phylodynamics of classical swine fever virus with emphasis on Ecuadorian strains

Author:
Garrido Haro, A. D.; Barrera Valle, M.; Acosta, A.; J. Flores, F.
Source:
Transboundary and emerging diseases 2018 v.65 no.3 pp. 782-790
ISSN:
1865-1674
Subject:
Classical swine fever virus,   etc   ; codons; emerging diseases; evolution; genetic variation; glycoproteins; models; pathogenesis; swine; virulence; Ecuador; Latin America; North America;     Show all 13 Subjects
Abstract:
... Classic swine fever virus (CSFV) is a Pestivirus from the Flaviviridae family that affects pigs worldwide and is endemic in several Latin American countries. However, there are still some countries in the region, including Ecuador, for which CSFV molecular information is lacking. To better understand the epidemiology of CSFV in the Americas, sequences from CSFVs from Ecuador were generated and a p ...
DOI:
10.1111/tbed.12803

8. Production of recombinant Erns protein of classical swine fever virus and assessment of its enzymatic activity: A recombinant Newcastle disease virus-based approach

Author:
Kumar, Rakesh; Kumar, Vishnu; Kumar, Sachin
Source:
Process biochemistry 2018 v.66 pp. 113-119
ISSN:
1359-5113
Subject:
Classical swine fever virus,   etc   ; Newcastle disease; Newcastle disease virus; enzyme activity; etiological agents; genes; hog cholera; proteins; ribonucleases; temperature; viruses;     Show all 11 Subjects
Abstract:
... Classical swine fever virus (CSFV) is an etiological agent of classical swine fever. The structure protein Erns of CSFV assists in the initial attachment of the virus to the host cell and its subsequent entry. Newcastle disease virus (NDV) has been used as a virus vector to express different proteins successfully. The unique characters of NDV lying in its broad host spectrum and ease in production ...
DOI:
10.1016/j.procbio.2017.12.001

9. Coordinated expression of vascular endothelial growth factor A and urokinase-type plasminogen activator contributes to classical swine fever virus Shimen infection in macrophages

Author:
Gong, Xiaocheng; Hu, Aoxue; Li, Xuepeng; He, Jun; Wu, Zhongxing; Zuo, Xi; Ning, Pengbo
Source:
BMC veterinary research 2019 v.15 no.1 pp. 82
ISSN:
1746-6148
Subject:
Classical swine fever virus,   etc   ; Western blotting; confocal microscopy; gene expression regulation; hemorrhage; hog cholera; innate immunity; macrophages; pathogenesis; proteins; quantitative polymerase chain reaction; regulator genes; transcription (genetics); translation (genetics); u-plasminogen activator; vascular endothelial growth factor A; virulent strains; viruses;     Show all 18 Subjects
Abstract:
... BACKGROUND: The Shimen strain of classical swine fever (CSF) virus (CSFV) causes CSF, which is mainly characterised by disseminated intravascular haemorrhage. Macrophages are an essential component of innate immunity against pathogenic microorganisms; however, the role of macrophages in CSF pathogenesis remains unclear. To illuminate the infective mechanism of CSFV, we used gene co-expression netw ...
DOI:
10.1186/s12917-019-1826-8

10. Development and evaluation of a real-time RT-PCR and a field-deployable RT-insulated isothermal PCR for the detection of Seneca Valley virus

Author:
Zhang, Jianqiang; Nfon, Charles; Tsai, Chuan-Fu; Lee, Chien-Hsien; Fredericks, Lindsay; Chen, Qi; Sinha, Avanti; Bade, Sarah; Harmon, Karen; Piñeyro, Pablo; Gauger, Phillip; Tsai, Yun-Long; Wang, Hwa-Tang Thomas; Lee, Pei-Yu Alison
Source:
BMC veterinary research 2019 v.15 no.1 pp. 168
ISSN:
1746-6148
Subject:
Classical swine fever virus,   etc   ; Enterovirus B; Foot-and-mouth disease virus; RNA; Seneca Valley virus; Vesicular exanthema of swine virus; Vesiculovirus; microbial detection; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; swine; swine diseases; transcription (genetics); viruses;     Show all 14 Subjects
Abstract:
... BACKGROUND: Seneca Valley virus (SVV) has emerged in multiple countries in recent years. SVV infection can cause vesicular lesions clinically indistinguishable from those caused by other vesicular disease viruses, such as foot-and-mouth disease virus (FMDV), swine vesicular disease virus (SVDV), vesicular stomatitis virus (VSV), and vesicular exanthema of swine virus (VESV). Sensitive and specific ...
DOI:
10.1186/s12917-019-1927-4

11. Identification of a novel cluster of PCV2 isolates from Meghalaya, India indicates possible recombination along with changes in capsid protein

Author:
Mukherjee, P.; Karam, A.; Chakraborty, A.K.; Baruah, S.; Pegu, R.; Das, S.; Milton, A.A.P.; Puro, K.; Sanjukta, R.; Ghatak, S.; Shakuntala, I.; Laha, R.G.; Sen, A.
Source:
Infection, genetics, and evolution 2019 v.71 pp. 7-15
ISSN:
1567-1348
Subject:
Classical swine fever virus,   etc   ; Porcine circovirus; Porcine circovirus-2; active sites; amino acids; coat proteins; disease outbreaks; epidemiological studies; financial economics; genetic variation; models; monitoring; mortality; phylogeny; planning; sequence alignment; swine; transportation; vaccines; viruses; India;     Show all 21 Subjects
Abstract:
... Documentation of the emergence of Porcine circovirus 2 (PCV2) infection and economic losses incurred due to high mortality has been reported worldwide. The prevalence and genetic diversity of the virus has been reported in Northeast India including the possible chances of Classical swine fever virus (CSFV) vaccine failure in pig population in this region resulting in major disease outbreak. Irresp ...
DOI:
10.1016/j.meegid.2019.02.026

12. TNF-α induced by porcine reproductive and respiratory syndrome virus inhibits the replication of classical swine fever virus C-strain

Author:
Chen, Dongjie; Liu, Xiaowen; Xu, Shengkui; Chen, Dengjin; Zhou, Lei; Ge, Xinna; Han, Jun; Guo, Xin; Yang, Hanchun
Source:
Veterinary microbiology 2019 v.234 pp. 25-33
ISSN:
0378-1135
Subject:
Classical swine fever virus,   etc   ; Porcine reproductive and respiratory syndrome virus; cell lines; immune response; live vaccines; mixed infection; pathogens; porcine reproductive and respiratory syndrome; receptors; signal transduction; swine; transcription factor NF-kappa B; tumor necrosis factor-alpha; vaccination; viruses;     Show all 15 Subjects
Abstract:
... Porcine productive and respiratory syndrome virus (PRRSV) and classical swine fever virus (CSFV) both are major pathogens of swine that pose a great threat to the Chinese pig industry. It has been found that PRRSV infection can lead to vaccination failure of CSFV C strain-derived modified live vaccine (CSFV-C) by interfering with the immune responses to the latter. To investigate whether PRRSV can ...
DOI:
10.1016/j.vetmic.2019.05.007

13. Virulence evaluation of classical swine fever virus subgenotype 2.1 and 2.2 isolates circulating in China

Author:
Gong, Wenjie; Li, Junhui; Wang, Zunbao; Sun, Jiumeng; Mi, Shijiang; Lu, Zongji; Cao, Jian; Dou, Zhihua; Sun, Yanjun; Wang, Pengjiang; Yuan, Ke; Zhang, Liying; Zhou, Xubin; He, Sun; Tu, Changchun
Source:
Veterinary microbiology 2019 v.232 pp. 114-120
ISSN:
0378-1135
Subject:
Classical swine fever virus,   etc   ; anorexia; antibodies; blood; conjunctivitis; constipation; death; disease course; dyspnea; edema; exudation; fever; gait; hemorrhage; hog cholera; leukopenia; lymph nodes; mortality; piglets; protein synthesis; subgenotype; vaccines; viremia; virulence; viruses; China;     Show all 26 Subjects
Abstract:
... Classical swine fever (CSF) remains an important pig disease in China, where it usually presents with mild or atypical clinical manifestations, with large scale outbreaks rarely seen. This has led to speculation about the possible circulation of viral strains of low virulence. To investigate this possibility, five field isolates within the predominant genotype 2 (2.1b, 2.1c, 2.1 h and 2.2) were ev ...
DOI:
10.1016/j.vetmic.2019.04.001

14. Classical swine fever virus non-structural proteins modulate Toll-like receptor signaling pathways in porcine monocyte-derived macrophages

Author:
Cao, Zhi; Yang, Qian; Zheng, Minping; Lv, Huifang; Kang, Kai; Zhang, Yanming
Source:
Veterinary microbiology 2019 v.230 pp. 101-109
ISSN:
0378-1135
Subject:
Classical swine fever virus,   etc   ; Toll-like receptor 3; gene expression; innate immunity; interferon-alpha; interferon-beta; interleukin-6; macrophages; messenger RNA; phosphorylation; secretion; signal transduction; swine; transcription (genetics); transcription factor NF-kappa B; translation (genetics); viral nonstructural proteins;     Show all 17 Subjects
Abstract:
... Toll-like receptors (TLRs) are crucial activators of the innate immune response that play various roles in viral infection. Studies have confirmed that classical swine fever virus (CSFV) infection has significant effects on the expression of immune effectors participating in TLR signaling pathways; however, the involvement of CSFV-encoded proteins in TLR signaling pathways remains unclear. In this ...
DOI:
10.1016/j.vetmic.2019.01.025

15. Endemic outbreaks due to the re‐emergence of classical swine fever after accidental introduction of modified live LOM vaccine on Jeju Island, South Korea

Author:
Jang, Guehwan; Kim, Joo‐Ah; Kang, Won‐Myoung; Yang, Hyoung‐Seok; Park, Changnam; Jeong, Kyongju; Moon, Sung‐Up; Park, Choi‐Kyu; Lyoo, Young S.; Lee, Changhee
Source:
Transboundary and emerging diseases 2019 v.66 no.2 pp. 634-639
ISSN:
1865-1674
Subject:
Classical swine fever virus,   etc   ; amino acids; emerging diseases; farms; genome; herds; hog cholera; issues and policy; livestock and meat industry; nucleotide sequences; phylogeny; risk; sequence analysis; swine; vaccination; vaccines; viral nonstructural proteins; virulence; South Korea;     Show all 19 Subjects
Abstract:
... After the unintentional vaccination of the LOM vaccine strain in 2014, classical swine fever virus (CSFV) reemerged in naïve pig herds on Jeju Island, South Korea, which had been a CSF‐free region with a non‐vaccination policy for a decade. Since the re‐emergence, endemic outbreaks of CSFV have occurred in the island, causing enormous damage to provincial pig farms. The present study reports the c ...
DOI:
10.1111/tbed.13121

16. Sub-subgenotype 2.1c isolates of classical swine fever virus are dominant in Guangdong province of China, 2018

Author:
Xing, Chaonan; Lu, Zongji; Jiang, Jianfeng; Huang, Liangzong; Xu, Jialun; He, Desheng; Wei, Zelin; Huang, Haijie; Zhang, Hongren; Murong, Cangyao; Tu, Changchun; Gong, Wenjie
Source:
Infection, genetics, and evolution 2019 v.68 pp. 212-217
ISSN:
1567-1348
Subject:
Classical swine fever virus,   etc   ; amino acid substitution; amino acids; cities; genes; herds; hog cholera; mortality; nucleotide sequences; phylogeny; pork industry; reverse transcriptase polymerase chain reaction; sequence analysis; sows; China;     Show all 15 Subjects
Abstract:
... Classical swine fever (CSF) continues to be a devastating infectious disease for the swine industry in China and commonly exists as wild or atypical types. From June 3rd to October 3rd, 2018, outbreaks of typical CSF cases with mortality rates of 42–86% occurred in 11 swine herds in five cities of Guangdong province, and were confirmed by RT-PCR. Phylogenetic analyses based on the nucleotide seque ...
DOI:
10.1016/j.meegid.2018.12.029

17. Molecular characterization of classical swine fever virus isolates from India during 2012-14

Author:
Khatoon, Elina; Barman, Nagendra N.; Deka, Manab; Rajbongshi, Gitika; Baruah, Kongkon; Deka, Nipu; Bora, Durlav P.; Kumar, Sachin
Source:
Acta tropica 2017
ISSN:
0001-706X
Subject:
Classical swine fever virus,   etc   ; genes; hog cholera; nucleotide sequences; phylogeny; swine; viruses; India;     Show all 8 Subjects
Abstract:
... Classical swine fever is a highly contagious and economically important viral disease of pigs. Outbreaks of classical swine fever virus (CSFV) were recorded in different places in the Kamrup district of Assam in India between the years 2012 and 2014. The nucleotide sequences of the 10 CSFV isolates were analyzed based on the partial nucleotide sequences of the E2, 5′NTR and NS5B genes. Phylogeneti ...
DOI:
10.1016/j.actatropica.2017.03.004

18. Complete genomic characteristics and pathogenic analysis of the newly emerged classical swine fever virus in China

Author:
Zhang, Hongliang; Leng, Chaoliang; Tian, Zhijun; Liu, Chunxiao; Chen, Jiazeng; Bai, Yun; Li, Zhen; Xiang, Lirun; Zhai, Hongyue; Wang, Qian; Peng, Jinmei; An, Tongqing; Kan, Yunchao; Yao, Lunguang; Yang, Xufu; Cai, Xuehui; Tong, Guangzhi
Source:
BMC veterinary research 2018 v.14 no.1 pp. 204
ISSN:
1746-6148
Subject:
Classical swine fever virus,   etc   ; farms; genetic variation; genomics; hog cholera; issues and policy; livestock and meat industry; pathogenicity; subgenotype; swine; vaccines; viruses; China;     Show all 13 Subjects
Abstract:
... BACKGROUND: Classical swine fever (CSF) is one of the most devastating and highly contagious viral diseases in the world. Since late 2014, outbreaks of a new sub-genotype 2.1d CSF virus (CSFV) had caused substantial economic losses in numbers of C-strain vaccinated swine farms in China. The objective of the present study was to explore the genomic characteristics and pathogenicity of the newly eme ...
DOI:
10.1186/s12917-018-1504-2
PubMed:
29940930
PubMed Central:
PMC6019732

19. Enhanced protective immunity to CSFV E2 subunit vaccine by using IFN-γ as immunoadjuvant in weaning piglets

Author:
Zhang, Huawei; Wen, Wei; Zhao, Zekai; Wang, Jianjian; Chen, Huanchun; Qian, Ping; Li, Xiangmin
Source:
Vaccine 2018 v.36 no.48 pp. 7353-7360
ISSN:
0264-410X
Subject:
Classical swine fever virus,   etc   ; adjuvants; antigens; cell-mediated immunity; genetic engineering; glycoproteins; hosts; immune response; immunogenicity; interferon-gamma; models; neutralizing antibodies; piglets; subunit vaccines; weaning;     Show all 15 Subjects
Abstract:
... The glycoprotein E2 of classical swine fever virus (CSFV) is a major immunogenic protein that induces neutralizing antibodies and protective immunity. Thus, E2 is a suitable target antigen for the development of genetically engineered CSFV vaccines. However, these vaccines cannot generate complete protective immunity in their hosts, thereby limiting the scope of applications under field conditions ...
DOI:
10.1016/j.vaccine.2018.10.030

20. Evolutionary dynamics of classical swine fever virus in South Korea: 1987–2017

Author:
An, Dong-Jun; Lim, Seong-in; Choe, SeEun; Kim, Ki-Sun; Cha, Ra Mi; Cho, In-Soo; Song, Jae-Young; Hyun, Bang-Hun; Park, Bong-Kyun
Source:
Veterinary microbiology 2018 v.225 pp. 79-88
ISSN:
0378-1135
Subject:
Classical swine fever virus,   etc   ; amino acid substitution; ancestry; antigens; effective population size; genes; genetic variation; hog cholera; risk; subgenotype; swine; wild boars; South Korea;     Show all 13 Subjects
Abstract:
... The 5′ UTR (n=102) and full-length E2 (n=37) genes of classical swine fever viruses (CSFVs) circulating in South Korea over the past 30 years (1987–2017) were examined to determine the evolutionary rate and estimated time of the most recent common ancestor (tMRCA). From 2000, the Korean classical swine fever (CSF) antigen changed from genotype 3 to 2, which comprises subgenotypes 2.1b (2002–2013) ...
DOI:
10.1016/j.vetmic.2018.09.020