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- Author:
- Ma, Zicheng; Liu, Mengda; Liu, Zhaohu; Meng, Fanliang; Wang, Hongyu; Cao, Longlong; Li, Yan; Jiao, Qiulin; Han, Zifeng; Liu, Sidang
- Source:
- BMC veterinary research 2021 v.17 no.1 pp. 17
- ISSN:
- 1746-6148
- Subject:
- Classical swine fever virus, etc ; Betaarterivirus suid 1; Porcine circovirus; Porcine circovirus-2; Porcine epidemic diarrhea virus; Suid alphaherpesvirus 1; Ursidae; area; blood serum; epidemiological studies; farms; financial economics; frequency; genes; information; mixed infection; pathogens; pork; sampling; subgenotype; swine; swine diseases; veterinary medicine; China; Show all 24 Subjects
- Abstract:
- ... BACKGROUND: Porcine circovirus type 2 (PCV2) is one of the crucial swine viral pathogens, caused porcine circovirus associated diseases (PCVAD). Shandong province is one of the most important pork producing areas and bears a considerable economic loss due to PCVAD. However, there is limited information on epidemiology and coinfection rate of PCV2 with other critical swine diseases in this area, su ...
- DOI:
- 10.1186/s12917-020-02718-4
-
https://dx.doi.org/10.1186/s12917-020-02718-4
- Author:
- Li, Cheng; Wang, Yifan; Zheng, Hongqing; Dong, Wang; Lv, Huifang; Lin, Jihui; Guo, Kangkang; Zhang, Yanming
- Source:
- Veterinary research 2020 v.51 no.1 pp. 22
- ISSN:
- 1297-9716
- Subject:
- Classical swine fever virus, etc ; antiviral properties; autophagy; genes; interferon-alpha; macrophages; swine; ubiquitin-protein ligase; virus replication; Show all 9 Subjects
- Abstract:
- ... Interferons (IFNs) induce the expression of interferon-stimulated genes (ISGs) for defense against numerous viral infections, including classical swine fever virus (CSFV). However, the mechanisms underlying the effect of ISGs on CSFV infection are rarely reported. In this study, we demonstrate that IFN-α treatment induces upregulation of ISG15 and thus attenuates CSFV replication. To determine whe ...
- DOI:
- 10.1186/s13567-020-00753-5
- PubMed:
- 32093773
- PubMed Central:
- PMC7038623
-
https://dx.doi.org/10.1186/s13567-020-00753-5
- Author:
- Bielefeldt-Ohmann, Helle
- Source:
- Viruses 2020 v.12 no.10
- ISSN:
- 1999-4915
- Subject:
- Classical swine fever virus, etc ; Border disease virus; Bovine viral diarrhea virus 1; cattle; economic impact; sheep industry; swine; viruses; Show all 8 Subjects
- Abstract:
- ... The genus Pestivirus, encompassing small positive-strand RNA viruses in the family Flaviviridae, comprises four viruses of very significant economic impact to the cattle, swine and sheep industries worldwide: bovine viral diarrhoea virus (BVDV) type 1 and type 2, classical swine fever virus (CSFV) and border disease virus (BDV) [...] ...
- DOI:
- 10.3390/v12101181
-
http://dx.doi.org/10.3390/v12101181
- Author:
- Chen, Jing; Wu, Yue; Wu, Xu-dan; Zhou, Jing; Liang, Xiao-dong; Baloch, Abdul Sattar; Qiu, Ya-feng; Gao, Song; Zhou, Bin
- Source:
- Veterinary microbiology 2020 v.243 pp. 108621
- ISSN:
- 0378-1135
- Subject:
- Classical swine fever virus, etc ; DNA viruses; RNA; antiviral properties; cytoplasm; guanosinetriphosphatase; mice; mutants; mutation; nucleocapsid proteins; swine; virus replication; Show all 12 Subjects
- Abstract:
- ... Mx proteins are interferon-induced GTPases that have broad antiviral activity against a wide range of RNA and DNA viruses. We previously demonstrated that porcine Mx1 protein (poMx1) inhibited the replication of classical swine fever virus (CSFV), an economically important Pestivirus, and that mouse Mx1 did so as well. It is unknown why the nucleus-localizing mouse Mx1 inhibits CSFV replication wh ...
- DOI:
- 10.1016/j.vetmic.2020.108621
-
https://dx.doi.org/10.1016/j.vetmic.2020.108621
- Author:
- Choe, SeEun; Shin, Jihye; Kim, Ki-Sun; Song, Sok; Cha, Ra Mi; Jung, Byung-Il; Hyun, Bang-Hun; Park, Bong-Kyun; An, Dong-Jun
- Source:
- Pathogens 2020 v.9 no.8
- ISSN:
- 2076-0817
- Subject:
- Classical swine fever virus, etc ; Bovine viral diarrhea virus 1; antibodies; antibody detection; hog cholera; passive immunity; pathogens; piglets; sows; vaccines; virulence; Show all 11 Subjects
- Abstract:
- ... Here, we investigated the protective efficacy provided by passive immunity induced by a classical swine fever (Flc-LOM-BEʳⁿˢ) vaccine with the newly developed DIVA (Differentiating Infected from Vaccinated Animals) function. Ten pigs (aged 40–60 days) with maternally derived antibodies (MDAs) obtained from sows inoculated with the Flc-LOM-BEʳⁿˢ vaccine were challenged with virulent classical swine ...
- DOI:
- 10.3390/pathogens9080608
-
http://dx.doi.org/10.3390/pathogens9080608
- Author:
- de Oliveira, Luís Guilherme; Mechler-Dreibi, Marina L.; Almeida, Henrique M. S.; Gatto, Igor R. H.
- Source:
- Viruses 2020 v.12 no.6
- ISSN:
- 1999-4915
- Subject:
- Classical swine fever virus, etc ; Bovine viral diarrhea virus 1; boars; genetic similarity; pathogens; piglets; signs and symptoms (animals and humans); sows; surveys; swine diseases; viruses; Show all 11 Subjects
- Abstract:
- ... Bovine viral diarrhea virus (BVDV) is an important pathogen belonging to the Pestivirus genus, Flaviviridae family, which comprises viral species that causes an economic impact in animal production. Cattle are the natural host of BVDV and the main source of infection for pigs and other animal species. Due to its antigenic and genetic similarity with other important pestiviruses such as Classical S ...
- DOI:
- 10.3390/v12060600
-
http://dx.doi.org/10.3390/v12060600
- Author:
- Vuono, Elizabeth A.; Ramirez-Medina, Elizabeth; Azzinaro, Paul; Berggren, Keith A.; Rai, Ayushi; Pruitt, Sarah; Silva, Ediane; Velazquez-Salinas, Lauro; Borca, Manuel V.; Gladue, Douglas P.
- Source:
- Viruses 2020 v.12 no.4
- ISSN:
- 1999-4915
- Subject:
- Classical swine fever virus, etc ; amino acids; cell lines; confocal microscopy; genes; glycoproteins; macrophages; mutants; swine; transcription (genetics); two hybrid system techniques; virulence; virus replication; viruses; Show all 14 Subjects
- Abstract:
- ... E2 is the major structural glycoprotein of the classical swine fever virus (CSFV). E2 has been shown to be involved in important virus functions such as replication and virulence in swine. Using the yeast two-hybrid system, we previously identified several host proteins specifically interacting with CSFV E2. Here, we analyze the protein interaction of E2 with SERTA domain containing protein 1 (SER ...
- DOI:
- 10.3390/v12040421
-
https://dx.doi.org/10.3390/v12040421
- Author:
- Zheng, Hui-Hua; Zhang, Shu-Jian; Cui, Jian-Tao; Zhang, Jia; Wang, Leyi; Liu, Fang; Chen, Hong-Ying
- Source:
- Molecular and cellular probes 2020 v.50 pp. 101524
- ISSN:
- 0890-8508
- Subject:
- Classical swine fever virus, etc ; Porcine circovirus-3; detection limit; diagnostic techniques; fluorescence; melting; mixed infection; quantitative polymerase chain reaction; surveys; swine; temperature; Show all 11 Subjects
- Abstract:
- ... In the present study, the SYBR green I-based duplex quantitative polymerase chain reaction (qPCR) was developed for simultaneous detection of classical swine fever virus (CSFV) and porcine circovirus 3 (PCV3). The assay was used to detect both CSFV and PCV3 in one sample by their distinct melting temperatures (melting peaks at 87°C for CSFV and 81.5 °C for PCV3), and no specific fluorescence signa ...
- DOI:
- 10.1016/j.mcp.2020.101524
-
https://dx.doi.org/10.1016/j.mcp.2020.101524
- Author:
- Vuono, Elizabeth A.; Ramirez-Medina, Elizabeth; Berggren, Keith; Rai, Ayushi; Pruitt, Sarah; Silva, Ediane; Velazquez-Salinas, Lauro; Gladue, Douglas P.; Borca, Manuel V.
- Source:
- Viruses 2020 v.12 no.4
- ISSN:
- 1999-4915
- Subject:
- Classical swine fever virus, etc ; amino acids; animal proteins; cell lines; glycoproteins; macrophages; mutants; mutation; swine; swine diseases; two hybrid system techniques; virulence; virus replication; viruses; Show all 14 Subjects
- Abstract:
- ... Interactions between the major structural glycoprotein E2 of classical swine fever virus (CSFV) with host proteins have been identified as important factors affecting virus replication and virulence. Previously, using the yeast two-hybrid system, we identified swine host proteins specifically interacting with CSFV E2. In this report, we use a proximity ligation assay to demonstrate that swine host ...
- DOI:
- 10.3390/v12040388
-
https://dx.doi.org/10.3390/v12040388
- Author:
- Yin, Mei; Hu, Dongfang; Li, Peng; Kong, Lingyun; Ning, Hongmei; Yue, Feng; Jiang, Jinqing; Wang, Xuannian
- Source:
- Journal of Veterinary Research 2020 v.64 no.1 pp. 9-14
- ISSN:
- 2450-8608
- Subject:
- Classical swine fever virus, etc ; antigens; cell lines; cell proliferation; clones; cloning (cells); disease control; kidneys; live vaccines; pathogenicity; phenotype; swine; swine diseases; vaccine development; viral load; virus replication; Show all 16 Subjects
- Abstract:
- ... Classical swine fever virus (CSFV) causes an economically important and highly contagious disease of pigs, leading to economic losses around the world. Attenuated live vaccines with CSFV antigens have played an important role in the prevention and control of the disease. Porcine kidney 15 (PK15) cells have been widely used for the propagation of CSFV, but this cell line is not efficient or homogen ...
- DOI:
- 10.2478/jvetres-2020-0020
- PubMed:
- 32258794
- PubMed Central:
- PMC7105985
-
http://dx.doi.org/10.2478/jvetres-2020-0020
- Author:
- Itakura, Yukari; Matsuno, Keita; Ito, Asako; Gerber, Markus; Liniger, Matthias; Fujimoto, Yuri; Tamura, Tomokazu; Kameyama, Ken-ichiro; Okamatsu, Masatoshi; Ruggli, Nicolas; Kida, Hiroshi; Sakoda, Yoshihiro
- Source:
- Virus research 2020 v.276 pp. 197809
- ISSN:
- 0168-1702
- Subject:
- Classical swine fever virus, etc ; amino acids; apoptosis; cell culture; cell lines; cytopathogenicity; hog cholera; interferons; mutants; necroptosis; reverse genetics; swine; vaccines; virulence; viruses; Show all 15 Subjects
- Abstract:
- ... Classical swine fever viruses (CSFVs) do typically not show cytopathic effect (CPE) in cell culture, while some strains such as vaccine strain the GPE⁻ induce CPE in the swine kidney-derived CPK-NS cell line cultured in serum-free medium. These latter strains commonly lack Nᵖʳᵒ-mediated inhibition of type-I interferon (IFN) induction. In order to explore the molecular mechanisms of GPE⁻-induced CP ...
- DOI:
- 10.1016/j.virusres.2019.197809
-
https://dx.doi.org/10.1016/j.virusres.2019.197809
- Author:
- Chen, Yuming; Zhu, Erpeng; Fan, Shuangqi; Ding, Hongxing; Ma, Shengming; Zhu, Mengjiao; Deng, Shaofeng; Chen, Jinding; Zhao, Mingqiu
- Source:
- Virology journal 2019 v.16 no.1 pp. 127
- ISSN:
- 1743-422X
- Subject:
- Classical swine fever virus, etc ; capsid; coat proteins; mutants; proteasome endopeptidase complex; signal peptide; ubiquitin; viruses; Show all 8 Subjects
- Abstract:
- ... BACKGROUND: Capsid (C) protein plays an important role in the replication of classical swine fever virus (CSFV). The ubiquitin proteasome system (UPS) involves in replication of many viruses via modulation of viral proteins. The relationship of CSFV with UPS is poorly understood and the impact of 26S proteasome on C protein has never been reported before. METHODS: In this study, fused C protein wi ...
- DOI:
- 10.1186/s12985-019-1238-1
- PubMed:
- 31694654
- PubMed Central:
- PMC6833258
-
https://dx.doi.org/10.1186/s12985-019-1238-1
- Author:
- Cao, Tong; Wang, Zuohuan; Li, Xiaoye; Zhang, Shengnan; Paudyal, Narayan; Zhang, Xian; Li, Xiaoliang; Fang, Weihuan
- Source:
- Virus genes 2019 v.55 no.2 pp. 238-242
- ISSN:
- 0920-8569
- Subject:
- Classical swine fever virus, etc ; RNA; antibody formation; fever; glycoproteins; protein synthesis; rabbits; spleen; vaccines; viruses; Show all 10 Subjects
- Abstract:
- ... The classical swine fever virus (CSFV) C-strain has been used as a vaccine strain for over 60 years in China. A recent study has demonstrated that the E2 protein of C-strain plays a major role in its adaptation to rabbits. E2 protein in combination with either Eʳⁿˢ or E1 confers rabbit adaptation for the C-strain, and the residues P108 and T109 in domain I of E2 are critical for rabbit adaptation. ...
- DOI:
- 10.1007/s11262-018-01631-1
-
http://dx.doi.org/10.1007/s11262-018-01631-1
- Author:
- de Oliveira, Luís Guilherme; Gatto, Igor Renan Honorato; Mechler-Dreibi, Marina Lopes; Almeida, Henrique M. S.; Sonálio, Karina; Storino, Gabriel Yuri
- Source:
- Viruses 2020 v.12 no.11
- ISSN:
- 1999-4915
- Subject:
- Classical swine fever virus, etc ; World Organization for Animal Health; animal health; death; disease control; disease eradication; farming systems; farms; guidelines; herds; hog cholera; industry; livestock production; monitoring; pig breeding; risk; slaughterhouses; swine; Brazil; Show all 19 Subjects
- Abstract:
- ... Classical swine fever virus (CSFV) causes one of the most critical diseases in the porcine industry worldwide. In Brazil, the first description of the infection was reported in 1888, and the national recognition of the first free zone (FZ) occurred in 2001. Brazil has been recently recognized (2015–2016) by the World Organisation for Animal Health (OIE) with an FZ involving 15 states and the Feder ...
- DOI:
- 10.3390/v12111327
-
http://dx.doi.org/10.3390/v12111327
- Author:
- Hao, Genxi; Zhang, Huawei; Chen, Huanchun; Qian, Ping; Li, Xiangmin
- Source:
- Pathogens 2020 v.9 no.10
- ISSN:
- 2076-0817
- Subject:
- Classical swine fever virus, etc ; cells; disease outbreaks; genetic variation; hog cholera; infection; laboratory animals; live vaccines; models; pathogenesis; pathogens; signs and symptoms (animals and humans); strains; subgenotype; swine; virulence; China; Show all 17 Subjects
- Abstract:
- ... Classical swine fever (CSF) caused by classical swine fever virus (CSFV) is a highly contagious and devastating disease. The traditional live attenuated C-strain vaccine is widely used to control disease outbreaks in China. Since 2000, subgenotype 2.1 has become dominant in China. Here, we isolated subgenotype 2.1c and 2.1d strains from CSF-suspected pigs. The genetic variations and pathogenesis o ...
- DOI:
- 10.3390/pathogens9100821
-
http://dx.doi.org/10.3390/pathogens9100821
- Author:
- Nannucci, Lapo; Barattini, Paolo; Bossis, Ioannis; Woźniakowski, Grzegorz; Balka, Gyula; Pugliese, Carolina
- Source:
- Journal of Veterinary Research 2020 v.64 no.1 pp. 15-23
- ISSN:
- 2450-8608
- Subject:
- Classical swine fever virus, etc ; African swine fever virus; Influenza A virus; Porcine reproductive and respiratory syndrome virus; animal viruses; diagnostic techniques; farmers; farms; leasing; questionnaires; research projects; stakeholders; swine; veterinarians; viruses; willingness to pay; Greece; Hungary; Italy; Poland; Show all 20 Subjects
- Abstract:
- ... A research project is underway aiming to develop a field diagnostic tool for six important viruses of the pig sector, namely: African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), porcine parvovirus (PPV), porcine circovirus (PCV2), and classical swine fever virus (CSFV). To obtain a preliminary sounding of the interest in this ...
- DOI:
- 10.2478/jvetres-2020-0016
- PubMed:
- 32258795
- PubMed Central:
- PMC7105983
-
http://dx.doi.org/10.2478/jvetres-2020-0016
- Author:
- Chang, Yafei; Deng, Yue; Li, Tianyu; Wang, Juan; Wang, Tongyan; Tan, Feifei; Li, Xiangdong; Tian, Kegong
- Source:
- Transboundary and emerging diseases 2020 v.67 no.2 pp. 564-571
- ISSN:
- 1865-1674
- Subject:
- Classical swine fever virus, etc ; Porcine circovirus-2; Porcine reproductive and respiratory syndrome virus; RNA; Suid alphaherpesvirus 1; Ungulate protoparvovirus 1; detection limit; diagnostic techniques; emerging diseases; industry; porcine reproductive and respiratory syndrome; recombinases; swine; Show all 13 Subjects
- Abstract:
- ... Porcine reproductive and respiratory syndrome virus (PRRSV) has varied constantly and circulated in the pig industry worldwide. The prevention and control of porcine reproductive and respiratory syndrome (PRRS) is complicated. A visual, sensitive and specific diagnostic method is advantageous to the control of PRRS. The collateral cleavage activity of LwCas13a is activated to degrade non‐targeted ...
- DOI:
- 10.1111/tbed.13368
-
http://dx.doi.org/10.1111/tbed.13368
- Author:
- Mósena, Ana C. S.; Weber, Matheus N.; Cibulski, Samuel P.; Silva, Mariana S.; Paim, Willian P.; Silva, Gustavo S.; Medeiros, Antônio A.; Viana, Nathália A.; Baumbach, Letícia F.; Puhl, Daniela E.; Silveira, Simone; Corbellini, Luis G.; Canal, Cláudio W.
- Source:
- Journal of veterinary diagnostic investigation 2020 v.32 no.1 pp. 136-141
- ISSN:
- 1943-4936
- Subject:
- Classical swine fever virus, etc ; Border disease virus; Bovine viral diarrhea virus 1; DNA primers; Suidae; World Organization for Animal Health; animal viruses; blood serum; herds; hosts; neutralization tests; reverse transcriptase polymerase chain reaction; ruminants; surveys; swine; swine diseases; viruses; Brazil; Show all 18 Subjects
- Abstract:
- ... The Pestivirus genus comprises species that affect animal health and productivity worldwide. Members of the Suidae family are hosts for classical swine fever virus (CSFV), an important pathogen tracked by the World Organization for Animal Health (OIE). However, swine are also susceptible to other pestivirus species that can result in disease or compromise CSFV detection. We searched for pestivirus ...
- DOI:
- 10.1177/1040638719896303
- PubMed:
- 31924139
- PubMed Central:
- PMC7003213
-
http://dx.doi.org/10.1177/1040638719896303
- Author:
- Cao, Tong; Li, Xiaoye; Xu, Yonghao; Zhang, Shengnan; Wang, Zuohuan; Shan, Ying; Sun, Jianhe; Fang, Weihuan; Li, Xiaoliang
- Source:
- Viruses 2019 v.11 no.11
- ISSN:
- 1999-4915
- Subject:
- Classical swine fever virus, etc ; dose response; epithelial cells; gene overexpression; interferons; mutants; swine; swine diseases; transcription (genetics); viruses; Show all 10 Subjects
- Abstract:
- ... Classical swine fever virus (CSFV) causes a contagious disease of pigs. The virus can break the mucosal barrier to establish its infection. Type III interferons (IFN-λs) play a crucial role in maintaining the antiviral state in epithelial cells. Limited information is available on whether or how CSFV modulates IFN-λs production. We found that IFN-λ3 showed dose-dependent suppr ...
- DOI:
- 10.3390/v11110998
- PubMed:
- 31683525
- PubMed Central:
- PMC6893713
-
http://dx.doi.org/10.3390/v11110998
- Author:
- Liang, Xiao-Dong; Zhang, Yun-Na; Liu, Chun-Chun; Chen, Jing; Chen, Xiong-Nan; Sattar Baloch, Abdul; Zhou, Bin
- Source:
- Veterinary microbiology 2019
- ISSN:
- 0378-1135
- Subject:
- Classical swine fever virus, etc ; antiviral properties; cholesterol; drugs; endocytosis; enzyme inhibitors; histone deacetylase; hydrophobicity; lysosomes; membrane proteins; virus replication; Show all 11 Subjects
- Abstract:
- ... The level of cholesterol in host cells has been demonstrated to affect viral infection. Our previous studies showed that cholesterol-rich membrane rafts mediated the entry of classical swine fever virus (CSFV) into PK-15 or 3D4/21 cells, but the role of cholesterol post entry was still not clear. In this study, we found that CSFV replication before fusion was affected when the cholesterol traffick ...
- DOI:
- 10.1016/j.vetmic.2019.108436
-
https://dx.doi.org/10.1016/j.vetmic.2019.108436
