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- Coombes, Janine L., et al. Show all 11 Authors
- Cell and tissue research 2019 v.375 no.2 pp. 409-424
- Salmonella Typhimurium; Toxoplasma gondii; animal models; cattle; confocal microscopy; cryopreservation; epithelial cells; host-pathogen relationships; human population; humans; intestinal crypts; jejunum; morbidity; mortality; pathogens; renewable resources; rodents; slaughterhouses; staining; stem cells; swine; zoonoses
- ... The in vitro 3D culture of intestinal epithelium is a valuable resource in the study of its function. Organoid culture exploits stem cells’ ability to regenerate and produce differentiated epithelium. Intestinal organoid models from rodent or human tissue are widely available whereas large animal models are not. Livestock enteric and zoonotic diseases elicit significant morbidity and mortality in ...
- Coombes, Janine L., et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.21 pp. E1913
- Toxoplasma gondii; animal models; mice; microscopy; monocytes; neutrophils; parasites; small intestine
- ... Toxoplasma gondii infection occurs through the oral route, but we lack important information about how the parasite interacts with the host immune system in the intestine. We used two-photon laser-scanning microscopy in conjunction with a mouse model of oral T. gondii infection to address this issue. T. gondii established discrete foci of infection in the small intestine, eliciting the recruitment ...
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