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- Cosnier, Frédéric, et al. Show all 6 Authors
- Journal of proteomics 2019 v.207 pp. 103451
- aerosols; breathing; cytoskeleton; gene expression regulation; histones; histopathology; inflammation; long term effects; lungs; nanoparticles; neutrophils; proteasome endopeptidase complex; protein secretion; protein synthesis; proteomics; rats; solubility; titanium dioxide; toxicity
- ... The pulmonary toxicological properties of inhaled titanium dioxide were studied using bronchoalveolar lavage fluid (BALF) cytology and proteomics analyses. Fischer 344 rats were exposed to 10 mg/m3 of TiO2 nanostructured aerosol by nose-only inhalation for 6 h/day, 5 days/week for 4 weeks. Lung samples were collected up to 180 post-exposure days. As previously described, cytological analyses of BA ...