Jump to Main Content
- Cui, Baofeng, et al. Show all 7 Authors
- Applied microbiology and biotechnology 2019 v.103 no.8 pp. 3367-3379
- B-lymphocytes; Foot-and-mouth disease virus; T-lymphocytes; adjuvants; antibody formation; cell-mediated immunity; disease control; epitopes; flagellin; foot-and-mouth disease; guinea pigs; immunization; immunogenicity; immunoglobulin G; interferon-gamma; interleukin-12; mice; neutralization; neutralizing antibodies; oligodeoxyribonucleotides; recombinant proteins; tumor necrosis factor-alpha; vaccines
- ... Many recent studies have shown that flagellin fused to heterologous antigens can induce significantly enhanced humoral and cellular immune responses through its adjuvant activity. Therefore, in this study, two key B cell epitopes and a truncated VP1 (ΔVP1) protein from foot-and-mouth disease virus (FMDV) were expressed as flagellin fusion proteins in different patterns. Specifically, ΔVP1 and two ...
- Cui, Baofeng, et al. Show all 13 Authors
- Virus research 2019 v.259 pp. 18-27
- Porcine epidemic diarrhea virus; amino acids; blood serum; diarrhea; financial economics; genes; genotype; immunoglobulin G; inactivated vaccines; morbidity; mortality; mutation; neutralizing antibodies; piglets; protective effect; swine diseases; virulence; viruses; China
- ... Since October 2010, severe porcine epidemic diarrhea (PED) outbreaks caused by highly virulent PED virus (PEDV) strains have occurred continuously in the Chinese pig population and caused considerable economic losses. Although PEDV vaccines based on classical PEDV strains have been widely used in China in recent years, the morbidity and mortality in piglets remain high. Therefore, virulent genotyp ...