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- De Benedetti, Stefania, et al. Show all 9 Authors
- Journal of the American Chemical Society 2017 v.139 no.20 pp. 6795-6798
- Pseudomonas aeruginosa; X-radiation; active sites; beta-lactamase; beta-lactams; catalysts; catalytic activity; gene expression; glycosidases; histidine; hydrolysis; models; molecular dynamics; mutagenesis; zinc
- ... The N-acetylglucosaminidase NagZ of Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, cell-wall-derived natural products. This reaction regulates gene expression for the β-lactam resistance enzyme, β-lactamase. The enzyme catalyzes hydrolysis of N-acetyl-β-d-glucosamine-(1→4)-1,6-anhydro-N-acetyl-β-d-muramyl-peptide (1) to N-acetyl-β-d-glucosamine (2) and 1, ...