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- DeMichele, Angela M., et al. Show all 11 Authors
- Cell 2017 v.170 pp. 352-366.e13
- RNA; RNA-binding proteins; blood; breast neoplasms; exosomes; fibroblasts; inflammation; metastasis; neoplasm cells; patients; receptors; stoichiometry; therapeutics
- ... Interactions between stromal fibroblasts and cancer cells generate signals for cancer progression, therapy resistance, and inflammatory responses. Although endogenous RNAs acting as damage-associated molecular patterns (DAMPs) for pattern recognition receptors (PRRs) may represent one such signal, these RNAs must remain unrecognized under non-pathological conditions. We show that triggering of str ...
- DeMichele, Angela, et al. Show all 9 Authors
- Biochemical and biophysical research communications 2013 v.431 pp. 617-622
- apoptosis; autophagy; bioinformatics; carcinogenesis; death; genes; humans; metastasis; microRNA; neoplasm cells; neoplasms; organelles; prediction; proteins; therapeutics
- ... In human epithelial cancers, the microRNA (miRNA) mir-30d is amplified with high frequency and serves as a critical oncomir by regulating metastasis, apoptosis, proliferation, and differentiation. Autophagy, a degradation pathway for long-lived protein and organelles, regulates the survival and death of many cell types. Increasing evidence suggests that autophagy plays an important function in epi ...
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- DeMichele, Angela, et al. Show all 33 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.19 pp. 7004-7009
- animal ovaries; biomarkers; chromosomes; comparative genomic hybridization; complementary DNA; epigenetics; gene expression regulation; genomics; humans; microRNA; microarray technology; non-coding RNA; ovarian neoplasms; transcription (genetics); tumor suppressor genes
- ... MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as negative gene regulators. miRNA deregulation is involved in the initiation and progression of human cancer; however, the underlying mechanism and its contributions to genome-wide transcriptional changes in cancer are still largely unknown. We studied miRNA deregulation in human epithelial ovarian cancer by integrativ ...
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