Jump to Main Content
- Dimopoulou, Myrto, et al. Show all 6 Authors
- Toxicology 2017
- azoles; biochemical pathways; biomarkers; biosynthesis; developmental toxicity; drugs; embryo culture; embryogenesis; genes; mechanism of action; rats; retinoic acid; screening; sterols; transcriptomics
- ... We evaluated the effect of six azoles on embryonic development in the rat whole embryo culture (WEC). Using the total morphological scoring system (TMS), we calculated the ID10 concentration (effective dose for 10% decrease in TMS). For evaluating gene specific responses, we combined previously and newly collected transcriptomics data of rat WEC exposed to a total of twelve azoles at their ID10 fo ...