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1. Role of wild birds in the spread of clade 2.3.4.4e H5N6 highly pathogenic avian influenza virus into South Korea and Japan

Author:
Dong-hun Lee,   et al.   ; Junghoon Kwon; Sungsu Youk;     Show all 3 Authors
Source:
Infection, genetics, and evolution 2022 v.101 pp. 105281
ISSN:
1567-1348
Subject:
Bayesian theory; Influenza A virus; Japan; avian influenza; biosecurity; evolution; genomics; infection; monitoring; phylogeography; poultry; waterfowl; China; South Korea; Vietnam
Abstract:
... H5Nx highly pathogenic avian influenza viruses (HPAIVs) have caused transboundary epizootics in poultry and wild birds. In 2016, the H5N6 subtype of clade 2.3.4.4e HPAIVs caused multiple outbreaks in Asia, including China, Japan, Korea, and Vietnam. However, the geographical spread pattern of 2.3.4.4e H5N6 HPAIV has not been clearly identified. To better understand the emergence and transmission h ...
DOI:
10.1016/j.meegid.2022.105281

2. Detection of newly introduced Y280‐lineage H9N2 avian influenza viruses in live bird markets in Korea

Author:
Dong‐Hun Lee,   et al.   ; Sungsu Youk; Andrew Y. Cho; Sol Jeong; Yu‐jin Kim; Sunhak Lee; Tae‐Hyeon Kim; Mary J. Pantin‐Jackwood; Chang‐Seon Song;     Show all 9 Authors
Source:
Transboundary and emerging diseases 2022 v.69 no.2 pp. 881-885
ISSN:
1865-1674
Subject:
Influenza A virus; avian influenza; chickens; farms; genes; genotype; humans; phylogeny; public health; China; Korean Peninsula
Abstract:
... We report the first detection of Y280‐lineage H9N2 avian influenza viruses in live bird markets in Korea during July 2020. The viruses were isolated from domestic ducks and chickens traded in three markets in two different provinces, indicating dispersal of the newly introduced viruses. Complete genome sequencing and comparative phylogenetic analyses of all eight gene segments of the viruses showe ...
DOI:
10.1111/tbed.14014

3. Characterization of Martelella soudanensis sp. nov., Isolated from a Mine Sediment

Author:
Dong-Hun Lee,   et al.   ; Jung-Yun Lee; Dong-Hun Kim;     Show all 3 Authors
Source:
Microorganisms 2021 v.9 no.8 pp. -
ISSN:
2076-2607
Subject:
aldehydes; amino acids; biogenesis; carbohydrates; genome; metabolism; nucleic acid hybridization; nucleotide sequences; prediction; quinones; sediments; Minnesota
Abstract:
... Gram-stain-negative, strictly aerobic, non-spore-forming, non-motile, and rod-shaped bacterial strains, designated NC18ᵀ and NC20, were isolated from the sediment near-vertical borehole effluent originating 714 m below the subsurface located in the Soudan Iron Mine in Minnesota, USA. The 16S rRNA gene sequence showed that strains NC18ᵀ and NC20 grouped with members of the genus Martelella, includi ...
DOI:
10.3390/microorganisms9081736

4. Chronic Ultraviolet Irradiation to the Skin Dysregulates Adrenal Medulla and Dopamine Metabolism In Vivo

Author:
Dong Hun Lee,   et al.   ; Hye-Sun Lim; Kyeong-No Yoon; Jin Ho Chung; Yong-Seok Lee; Gunhyuk Park;     Show all 6 Authors
Source:
Antioxidants 2021 v.10 no.6 pp. -
ISSN:
2076-3921
Subject:
adrenal medulla; bioactive properties; blood; brain; chronic exposure; dopamine; histology; homeostasis; irradiation; metabolism; mice; norepinephrine; tyrosine 3-monooxygenase; ultraviolet radiation
Abstract:
... Ultraviolet (UV) radiation has a strong biological effect on skin biology, and it switches on adaptive mechanisms to maintain homeostasis in organs such as the skin, adrenal glands, and brain. In this study, we examined the adaptation of the body to repeated bouts of UVB radiation, especially with respect to the catecholamine synthesis pathway of the adrenal glands. The effects of UVB on catechola ...
DOI:
10.3390/antiox10060920

5. Evolution of H9N2 avian influenza viruses in Iran, 2017–2019

Author:
Dong‐Hun Lee,   et al.   ; Mohsen Bashashati; David H. Chung; Mohammad Hossein Fallah Mehrabadi;     Show all 4 Authors
Source:
Transboundary and emerging diseases 2021 v.68 no.6 pp. 3405-3414
ISSN:
1865-1674
Subject:
Influenza A virus; amino acids; avian influenza; enzootic diseases; genes; genetic variation; glycosylation; hemagglutinins; host specificity; mammals; monitoring; monophyly; population dynamics; poultry; public health; sialidase; Iran
Abstract:
... Since its first detection in 1998, avian influenza virus (AIV) subtype H9N2 has been enzootic in Iran. To better understand the evolutionary history of H9N2 viruses in Iran, we sequenced 15 currently circulating H9N2 viruses from domestic poultry during 2017–2019 and performed phylogenetic analysis of complete genome sequences. Phylogenetic analyses indicated that the Iranian H9N2 viruses formed m ...
DOI:
10.1111/tbed.13944

6. Pathobiological Origins and Evolutionary History of Highly Pathogenic Avian Influenza Viruses

Author:
Dong-Hun Lee,   et al.   ; Miria Ferreira; David Swayne;     Show all 3 Authors
Source:
Cold Spring Harbor perspectives in medicine 2020 v.10 no.5 pp. -
ISSN:
2157-1422
Subject:
Influenza A virus; amino acids; avian influenza; disease outbreaks; disease surveillance; evolution; genetic variation; hemagglutinins; insertional mutagenesis; microbial detection; molecular epidemiology; poultry; viral proteins; virulence; virulent strains; Africa; Asia; Europe; North America; Pacific Ocean Islands; South America
Abstract:
... High-pathogenicity avian influenza (HPAI) viruses have arisen from low-pathogenicity avian influenza (LPAI) viruses via changes in the hemagglutinin proteolytic cleavage site, which include mutation of multiple nonbasic to basic amino acids, duplication of basic amino acids, or recombination with insertion of cellular or viral amino acids. Between 1959 and 2019, a total of 42 natural, independent ...
Handle:
10113/6964476
DOI:
10.1101/cshperspect.a038679

7. Whole-Genome Sequencing Analysis of SalmonellaEnterica Serotype Enteritidis Isolated from Poultry Sources in South Korea, 2010–2017

Author:
Dong-Hun Lee,   et al.   ; Ji-Yeon Hyeon; Shaoting Li; David A. Mann; Shaokang Zhang; Kyu-Jik Kim; Xiangyu Deng; Chang-Seon Song;     Show all 8 Authors
Source:
Pathogens 2021 v.10 no.1 pp. -
ISSN:
2076-0817
Subject:
aminoglycosides; antibiotic resistance; humans; multilocus sequence typing; phylogeny; salmonellosis; serotypes; single nucleotide polymorphism; supply chain; virulence; South Korea
Abstract:
... Salmonella enterica subsp. enterica serotype Enteritidis (SE) is recognized as a major cause of human salmonellosis worldwide, and most human salmonellosis is due to the consumption of contaminated poultry meats and poultry byproducts. Whole-genome sequencing (data were obtained from 96 SE isolates from poultry sources, including an integrated broiler supply chain, farms, slaughterhouses, chicken ...
DOI:
10.3390/pathogens10010045

8. Subsea permafrost as a potential major source of dissolved organic matter to the East Siberian Arctic Shelf

Author:
Dong-Hun Lee,   et al.   ; Meilian Chen; Ji-Hoon Kim; Yun Kyung Lee; Young Keun Jin; Jin Hur;     Show all 6 Authors
Source:
Science of the total environment 2021 v.777 pp. 146100
ISSN:
0048-9697
Subject:
carbon dioxide; climate; dissolved organic carbon; environment; fluorescence; molecular weight; permafrost; sediments; statistical analysis; wavelengths; Arctic Ocean; Arctic region
Abstract:
... Arctic subsea permafrost contains more organic carbon than the terrestrial counterpart (~1400 Pg C vs. ~1000 Pg C) and is undergoing fast degradation (at rates of ~10 to 30 cm yr⁻¹ over the past 3 decades) in response to climate warming. Yet the flux of organic carbon sequestered in the sediments of subsea permafrost to overlying water column, which can trigger enormous positive carbon-climate fee ...
DOI:
10.1016/j.scitotenv.2021.146100

9. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Dog in Connecticut in February 2021

Author:
Dong-Hun Lee,   et al.   ; Zeinab H. Helal; Junwon Kim; Amelia Hunt; Alyza Barbieri; Natalie Tocco; Salvatore Frasca; Kirklyn Kerr; Ji-Yeon Hyeon; David H. Chung; Guillermo Risatti;     Show all 11 Authors
Source:
Viruses 2021 v.13 no.11 pp. -
ISSN:
1999-4915
Subject:
RNA; Severe acute respiratory syndrome coronavirus 2; dogs; epidemiology; genetic similarity; genome; hybridization; necropsy; phylogeny; public health; quantitative polymerase chain reaction; reverse transcription; viruses; winter; zoonoses; Connecticut
Abstract:
... We report the first detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a 3-month-old dog in Connecticut that died suddenly and was submitted to the state veterinary diagnostic laboratory for postmortem examination. Viral RNA was detected in multiple organs of the dog by reverse transcription real time-PCR (RT-qPCR). Negative and positive sense strands of viral RNA were vi ...
DOI:
10.3390/v13112141

10. Subclinical Infection and Transmission of Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Virus in Mandarin Duck (Aix galericulata) and Domestic Pigeon (Columbia livia domestica)

Author:
Dong-Hun Lee,   et al.   ; Sol Jeong; Jung-Hoon Kwon; Sun-Hak Lee; Yu-Jin Kim; Jei-Hyun Jeong; Jung-Eun Park; Weon-Hwa Jheong; Chang-Seon Song;     Show all 9 Authors
Source:
Viruses 2021 v.13 no.6 pp. -
ISSN:
1999-4915
Subject:
Aix galericulata; Columba livia; Influenza A virus; avian influenza; direct contact; indirect contact; mortality; pathogenicity; poultry; viral antigens; viruses; Africa; Asia; Europe; North America
Abstract:
... Since 2014, H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIV) have caused outbreaks in wild birds and poultry in multiple continents, including Asia, Europe, Africa, and North America. Wild birds were suspected to be the sources of the local and global spreads of HPAIV. This study evaluated the infectivity, pathogenicity, and transmissibility of clade 2.3.4.4 H5N6 HPAIV in manda ...
DOI:
10.3390/v13061069

11. Integrated approach for quantitative estimation of particulate organic carbon sources in a complex river system

Author:
Dong-Hun Lee,   et al.   ; Seung-Hee Kim; Eun-Ji Won; Min-Seob Kim; Jin Hur; Kyung-Hoon Shin;     Show all 6 Authors
Source:
Water research 2021 v.199 pp. 117194
ISSN:
0043-1354
Subject:
biomarkers; cholesterol; computer simulation; coprostanol; land use; particulate organic carbon; research; rivers; water; watersheds; South Korea
Abstract:
... Despite receiving a considerable amount of attention in the past, quantitative and systematic estimation of the source contributions for different organic carbons (OCs) in complex river systems is still challenging. In this study, we tested an integrated framework using field data of bulk elements and lipid biomarkers and hydrological modeling (hydrological simulation program FORTRAN, HSPF) for th ...
DOI:
10.1016/j.watres.2021.117194

12. Association of frequent intake of fast foods, energy drinks, or convenience food with atopic dermatitis in adolescents

Author:
Dong Hun Lee,   et al.   ; Soo Ick Cho; Hanjae Lee; Kyu-Han Kim;     Show all 4 Authors
Source:
European journal of nutrition 2020 v.59 no.7 pp. 3171-3182
ISSN:
1436-6207
Subject:
Internet; atopic dermatitis; cross-sectional studies; energy; food allergies; food consumption; food intake; odds ratio; prepared foods; risk behavior; surveys; youth; Korean Peninsula
Abstract:
... PURPOSE: Specific food consumption, besides food allergy, may aggravate atopic dermatitis (AD). However, previous reports on the association between AD and food intake in adolescents are scarce. The aim of this study was to determine the relationship between AD and specific food consumption frequency in adolescents. METHODS: A cross-sectional analysis using data from the Korea Youth Risk Behavior ...
DOI:
10.1007/s00394-019-02157-4

13. Genetic features of Salmonella enterica subspecies diarizonae serovar 61:k:1,5 isolated from abortion cases in sheep, United States, 2020

Author:
Dong-Hun Lee,   et al.   ; Ji-Yeon Hyeon; Zeinab H. Helal; Robert Polkowski; Mizuki Heishima; Junwon Kim; Guillermo R. Risatti;     Show all 7 Authors
Source:
Research in veterinary science 2021 v.138 pp. 125-136
ISSN:
0034-5288
Subject:
Salmonella enterica; aminoglycosides; antibiotic resistance genes; complementary genes; flocks; genomics; humans; phylogeny; plasmids; provenance; pseudogenes; research; serotypes; sheep; veterinary medicine; virulence; Canada; Connecticut
Abstract:
... Salmonella enterica subspecies diarizonae serovar 61:(k):1, 5, (7) (sheep associated S. diarizonae, SASd) is the most common Salmonella serotype identified in sheep flocks. Despite the involvement with animal and human infections, there is limited information regarding virulence profiles of SASds and their antibiotic resistance gene complement, particularly for those circulating in the U.S. In thi ...
DOI:
10.1016/j.rvsc.2021.06.007

14. Comparison of the stability of eGFP displayed on the Bacillus subtilis spore surface using CotB and C-terminally truncated CotB proteins as an anchoring motif under extreme conditions

Author:
Dong Hun Lee,   et al.   ; Soo Ji Kang; Eun Ah Park; Kwang Won Hong;     Show all 4 Authors
Source:
Applied biological chemistry 2019 v.62 no.1 pp. 41
ISSN:
2468-0842
Subject:
Bacillus subtilis; DNA fragmentation; coat proteins; flow cytometry; genetic vectors; green fluorescent protein; heat; pH; peptidase K; spores; trypsin
Abstract:
... We investigated the expression and stability of enhanced green fluorescent protein (eGFP) under extreme conditions using two types of high-copy-number vectors and two types of anchoring motifs (CotB and C-terminally truncated ∆CotB spore coat proteins) for the development of a spore surface display system in Bacillus subtilis. The fused cotB-gfp and ΔcotB-gfp DNA fragments were cloned into the pUB ...
DOI:
10.1186/s13765-019-0448-y

15. Therapeutic potency of fermented field water-dropwort (Oenanthe javanica (Blume) DC.) in ethanol-induced liver injury

Author:
Dong Hun Lee,   et al.   ; Jong Sung Lee; Il Ho Lee; Jin Tae Hong;     Show all 4 Authors
Source:
RSC advances 2020 v.10 no.3 pp. 1544-1551
ISSN:
2046-2069
Subject:
Oenanthe javanica; acetyl-CoA carboxylase; diet; ethanol; fatty-acid synthase; fermentation; glutathione; hepatitis; hypertension; jaundice; lipid peroxidation; liver; males; oxidative stress; sterols; triacylglycerols; Asia
Abstract:
... Alcohol overconsumption and abuse leads to alcoholic liver disease (ALD), which is a major chronic liver disease worldwide. Field water-dropwort (Oenanthe javanica (Blume) DC.) is a small perennial herb and has been cultivated in Asia for thousands of years and traditionally used to treat various diseases including hepatitis, jaundice, hypertension and polydipsia, as well as its therapeutic benefi ...
DOI:
10.1039/c9ra08976d

16. Evolutionary history of H5 highly pathogenic avian influenza viruses (clade 2.3.4.4c) circulating in Taiwan during 2015–2018

Author:
Dong-Hun Lee,   et al.   ; Chih-Wei Huang; Li-Hsuan Chen; Yu-Pin Liu; Wan-Chen Li; Ming-Shiuh Lee; Yen-Ping Chen; Fan Lee; Chwei-Jang Chiou; Yu-Ju Lin;     Show all 10 Authors
Source:
Infection, genetics, and evolution 2021 v.92 pp. 104885
ISSN:
1567-1348
Subject:
Bayesian theory; Influenza A virus; Japan; ancestry; avian influenza; biosecurity; geese; gene pool; genes; genetic variation; hemagglutinins; infection; models; monitoring; phylogeny; sialidase; statistical analysis; viruses; Taiwan
Abstract:
... The highly pathogenic avian influenza (HPAI) virus A/goose/Guangdong/1/96 H5N1 (Gs/GD) lineage has been transmitted globally and has caused deaths in wild birds, poultry, and humans. Clade 2.3.4.4c, one of the subclades of the Gs/GD lineage, spread through Taiwan in late 2014 and become an endemic virus. We analyzed 239 newly sequenced HPAI clade H5Nx isolates to explore the phylogenetic relations ...
DOI:
10.1016/j.meegid.2021.104885

17. Evaluation of the quantity and the carbon isotopic composition of amino acids by using diverse sample residues after lipid extraction

Author:
Dong-Hun Lee,   et al.   ; Hee Young Yun; Hyuntae Choi; Eunji Won; Kyung-Hoon Shin;     Show all 5 Authors
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.18 pp. 4383-4391
ISSN:
1618-2642
Subject:
analytical chemistry; biogeochemistry; carbon; ecology; fish; particulate organic matter; soil; stable isotopes
Abstract:
... Compound-specific stable isotope analysis (CSIA) becomes a critical tool in the fields of ecology and biogeochemistry to trace basal carbon sources such as amino acids (AAs) and fatty acids (FAs) in natural environments. However, in many studies, either AAs or FAs have been analyzed due to restricted sample amounts. The aim of this study is to report a single-sample preparation method by identifyi ...
DOI:
10.1007/s00216-020-02679-5

18. Agricultural and geographic factors shaped the North American 2015 highly pathogenic avian influenza H5N2 outbreak

Author:
Dong-Hun Lee,   et al.   ; Joseph T. Hick; Venkata Duwuri; Mia Kim Torchetti; David Swayne; Justin Bahi;     Show all 6 Authors
Source:
PLOS pathogens 2020 v.16 no.1 pp. e1007857
ISSN:
1553-7374
Subject:
avian influenza; genome; laying hens; phylogeny; poultry production; sample size; spatial data; viruses
Abstract:
... The 2014–2015 highly pathogenic avian influenza (HPAI) H5NX outbreak represents the largest and most expensive HPAI outbreak in the United States to date. Despite extensive traditional and molecular epidemiological studies, factors associated with the spread of HPAI among midwestern poultry premises remain unclear. To better understand the dynamics of this outbreak, 182 full genome HPAI H5N2 seque ...
Handle:
10113/6964475
DOI:
10.1371/journal.ppat.10 07857

19. Peptides in the hemolymph of Hermetia illucens larvae completely inhibit the growth of Klebsiella pneumonia in vitro and in vivo

Author:
Dong-Hun Lee,   et al.   ; Ki-Back Chu; Hae-Ji Kang; Su-Hwa Lee; Fu-Shi Quan;     Show all 5 Authors
Source:
Journal of Asia-Pacific entomology 2020 v.23 no.1 pp. 36-43
ISSN:
1226-8615
Subject:
Hermetia illucens; Klebsiella pneumoniae; antibacterial properties; antibiotics; hemolymph; high performance liquid chromatography; inflammation; insect larvae; lungs; mice; peptides; respiratory tract diseases; reversed-phase liquid chromatography; tandem mass spectrometry
Abstract:
... Extensive use of antibiotics has caused the microbial resistance to rise drastically within the last few decades, and new approaches are therefore needed to develop effective antibacterial substances. In this study, we identified peptide in the hemolymph of Hermetia illucens larvae using reverse-phase chromatography, HPLC and Nano-LC-ESI-MS/MS system. We investigated the antibacterial effect of HP ...
DOI:
10.1016/j.aspen.2019.10.004

20. The pathogenicity and transmission of live bird market H2N2 avian influenza viruses in chickens, Pekin ducks, and guinea fowl

Author:
Dong-Hun Lee,   et al.   ; Mo Jongseo; Sungsu Youk; Mary J. Pantin-Jackwood; David L. Suarez; Mary Lea Killian; Nichole H. Bergeson; Erica Spackman;     Show all 8 Authors
Source:
Veterinary microbiology 2021 v.260 no. pp. 109180
ISSN:
0378-1135
Subject:
Pekin; avian influenza; chickens; guineafowl; live bird markets; nucleotide sequences; pandemic; pathogenicity; public health; sialidase; viruses
Abstract:
... H2N2 subtype low pathogenic avian influenza viruses (LPAIVs) have persisted in live bird markets (LBMs) in the Northeastern United States since 2014. Although unrelated to the 1957 pandemic H2N2 lineage, there is concern that the virus could have animal and public health consequences because of high contact with humans and numerous species in the LBM system. The pathogenicity, infectivity, and tra ...
Handle:
10113/7438344
DOI:
10.1016/j.vetmic.2021.109180