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You searched for: Subject "Drosophila melanogaster" Remove constraint Subject: "Drosophila melanogaster"
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1. Metastatic effects of environmental carcinogens mediated by MAPK and UPR pathways with an in vivo Drosophila Model

Author:
Fangnon Firmin Fangninou; Zhenyang Yu; Zhuo Li; Awoke Guadie; Wenzhe Li; Lei Xue; Daqiang Yin
Source:
Journal of hazardous materials 2023 v.441 pp. 129826
ISSN:
0304-3894
Subject:
Drosophila melanogaster,   etc   ; body weight; cadmium chloride; fruit flies; larvae; locomotion; metastasis; models; mortality; neoplasms; perfluorooctanoic acid;     Show all 11 Subjects
Abstract:
... Metastasis includes tumor invasion and migration and underlies over 90% of cancer mortality. The metastatic effects of environmental carcinogens raised serious health concerns. However, the underlying mechanisms remained poorly studied. In the present study, an in vivo Rasⱽ¹²/lgl⁻/⁻ model of the fruitfly, Drosophila melanogaster, with an 8-day exposure was employed to explore the metastatic effect ...
DOI:
10.1016/j.jhazmat.2022.129826

2. An analysis of direct and indirect effects in Drosophila melanogaster undergoing a few cycles of experimental evolution for stress-related traits

Author:
Dau Dayal Aggarwal; Prachi Mishra; Manvender Singh
Source:
Comparative biochemistry and physiology 2023 v.263 pp. 110795
ISSN:
1096-4959
Subject:
Drosophila melanogaster,   etc   ; body fat; cold; cold tolerance; copulation; directed evolution; larval development; life history; longevity; starvation; stress tolerance; trehalose;     Show all 12 Subjects
Abstract:
... The physiological mechanisms underpinning adaptations to starvation and cold stresses have been extensively studied in Drosophila, yet the understanding of correlated changes in stress-related and life-history traits, as well as the energetics of stress tolerance, still remains elusive. To answer the questions empirically in this context, we allowed D. melanogaster to evolve for either increased s ...
DOI:
10.1016/j.cbpb.2022.110795

3. Molecular toxicity and defense mechanisms induced by silver nanoparticles in Drosophila melanogaster

Author:
Zhidi Wang; Liying Zhang; Xing Wang
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 616-629
ISSN:
1001-0742
Subject:
Drosophila melanogaster,   etc   ; DNA damage; cell viability; dose response; eclosion; fat body; fecundity; genes; hemocytes; metallothionein; nanosilver; pupation; sequence analysis; toxicity; China;     Show all 15 Subjects
Abstract:
... The widely use of silver nanoparticles (AgNPs) as antimicrobial agents gives rise to potential environmental risks. AgNPs exposure have been reported to cause toxicity in animals. Nevertheless, the known mechanisms of AgNPs toxicity are still limited. In this study, we systematically investigated the toxicity of AgNPs exposure using Drosophila melanogaster. We show here that AgNPs significantly de ...
DOI:
10.1016/j.jes.2021.12.027

4. Prediction of intestinal stem cell regulatory genes from Drosophila gut damage model created using multiple inducers: Differential gene expression-based protein-protein interaction network analysis

Author:
Seung Hun Lee; Dooseon Hwang; Tae-Won Goo; Eun-Young Yun
Source:
Developmental and comparative immunology 2023 v.138 pp. 104539
ISSN:
0145-305X
Subject:
Drosophila melanogaster,   etc   ; gene expression regulation; genes; homeostasis; innate immunity; intestines; models; oral administration; prediction; protein-protein interactions; sequence analysis; stem cells;     Show all 12 Subjects
Abstract:
... Intestinal tissue functions in innate immunity to prevent the entry of harmful substances, and to maintain homeostasis through the constant proliferation of intestinal stem cells (ISC). To understand the mechanisms which regulate ISC in response to gut damage, we identified 81 differentially expressed genes (DEGs) through RNA-seq analysis after oral administration of three intestinal-damaging subs ...
DOI:
10.1016/j.dci.2022.104539

5. Evolution of the dorsoventral axis in insects: the changing role of Bone Morphogenetic Proteins

Author:
Daniel Bressan; Helena Marcolla Araujo
Source:
Current opinion in insect science 2022 v.49 pp. 1-7
ISSN:
2214-5745
Subject:
Drosophila melanogaster,   etc   ; coevolution; genome; insects; ligands;     Show all 5 Subjects
Abstract:
... Embryonic dorsal-ventral (DV) patterning by Bone Morphogenetic Proteins (BMPs) is a conserved feature of Bilateria, based on graded BMP activity set up by diffusible BMP ligands and Chordin/Sog antagonists. In the fly Drosophila melanogaster BMP function is secondary to patterning by the Toll pathway, suggesting a more restricted role for BMPs in insects. With widespread genome sequencing technolo ...
DOI:
10.1016/j.cois.2021.09.004

6. A phylogenetic analysis between humans and D. melanogaster: A repertoire of solute carriers in humans and flies

Author:
Mikaela M. Ceder; Robert Fredriksson
Source:
Gene 2022 v.809 pp. 146033
ISSN:
0378-1119
Subject:
Drosophila melanogaster,   etc   ; databases; genes; humans; phylogeny; solutes;     Show all 6 Subjects
Abstract:
... The solute carrier (SLC) superfamily is the largest group of transporters in humans, with the role to transport solutes across plasma membranes. The SLCs are currently divided into 65 families with 430 members. Here, we performed a detailed mining of the SLC superfamily and the recent annotated family of “atypical” SLCs in human and D. melanogaster using Hidden Markov Models and PSI-BLAST. Our ana ...
DOI:
10.1016/j.gene.2021.146033

7. Cellular basis of limb morphogenesis

Author:
John Rallis; Anastasios Pavlopoulos
Source:
Current opinion in insect science 2022 v.50 pp. 100887
ISSN:
2214-5745
Subject:
Drosophila melanogaster,   etc   ; Parhyale hawaiensis; genome; insects; mechanics; morphogenesis;     Show all 6 Subjects
Abstract:
... How the size and shape of developing tissues is encoded in the genome has been a longstanding riddle for biologists. Constituent cells integrate several genetic and mechanical signals to decide whether to divide, die, change shape or position. We review here how morphogenetic cell behaviors contribute to leg formation from imaginal disc epithelia in the insect Drosophila melanogaster, as well as t ...
DOI:
10.1016/j.cois.2022.100887

8. Systematic Identification of Microproteins during the Development of Drosophila melanogaster

Author:
Zhiwei Wang; Ni Pan; Jiahao Yan; Jian Wan; Cuihong Wan
Source:
Journal of proteome research 2022 v.21 no.4 pp. 1114-1123
ISSN:
1535-3907
Subject:
Drosophila melanogaster,   etc   ; oviposition; polypeptides; proteome; research; synthetic peptides;     Show all 6 Subjects
Abstract:
... Short open reading frame-encoded peptides (SEPs) are microproteins with less than 100 amino acids that play an essential role in the growth and development of organisms. There are plenty of short open reading frames in Drosophila melanogaster that potentially code polypeptides. We chose 11 time points during the life cycle of Drosophila to investigate microproteins, particularly those related to d ...
DOI:
10.1021/acs.jproteome.2c00004

9. Dissecting, fixing, and visualizing the Drosophila pupal notum

Author:
White James S.; LaFever Kimberly S.; Page-McCaw Andrea
Source:
Journal of visualized experiments 2022 no.182 pp. e63682
ISSN:
1940-087X
Subject:
Drosophila melanogaster,   etc   ; adults; epithelium; integument; mechanics; metamorphosis; pupae;     Show all 7 Subjects
Abstract:
... The pupae of Drosophila melanogaster are immobile for several days during metamorphosis, during which they develop a new body with a thin transparent adult integument. Their immobility and transparency make them ideal for in vivo live imaging experiments. Many studies have focused on the dorsal epithelial monolayer of the pupal notum because of its accessibility and relatively large size. In addit ...
DOI:
10.3791/63682

10. Drosophila melanogaster as an emerging model host for entomopathogenic fungi

Author:
Luis A. Ramírez-Camejo; Paul Bayman; Luis C. Mejía
Source:
Fungal biology reviews 2022 pp. -
ISSN:
1749-4613
Subject:
Drosophila melanogaster,   etc   ; biological insect control; fruit flies; mycology;     Show all 4 Subjects
Abstract:
... Entomopathogenic fungi (EPF) infect insects and are of interest for understanding host-pathogen interactions and biological control of insect pests. The fruit fly Drosophila melanogaster offers an excellent model system for exploring the biology of EPF and their interactions with insects. In this review, we describe the advantages of using D. melanogaster as a model system to study EPF and highlig ...
DOI:
10.1016/j.fbr.2022.09.001

11. Molecular physiology of copper in Drosophila melanogaster

Author:
Richard Burke
Source:
Current opinion in insect science 2022 v.51 pp. 100892
ISSN:
2214-5745
Subject:
Drosophila melanogaster,   etc   ; copper; homeostasis; insects; neurons; toxicity; transcription (genetics);     Show all 7 Subjects
Abstract:
... In this review, I look at advances made in our understanding of the molecular physiology of copper homeostasis in the vinegar fly Drosophila melanogaster over the past five years, focussing in particular on the most recent 24 months. Firstly, I review publications investigating the physiological and genetic basis of dietary copper toxicity and tolerance, with particular attention paid to the ident ...
DOI:
10.1016/j.cois.2022.100892

12. New Mutations in the 5′ Region of the Notch Gene Affect Drosophila melanogaster Oogenesis

Author:
Elena I. Volkova; Natalya V. Dorogova; Oleg V. Andreyenkov; Saveliy A. Tikhomirov; Sergey A. Demakov
Source:
Journal of developmental biology 2022 v.10 no.3 pp. -
ISSN:
2221-3759
Subject:
Drosophila melanogaster,   etc   ; eggs; epithelium; introns; morphogenesis; oocytes; oogenesis; transgenes;     Show all 8 Subjects
Abstract:
... The Notch pathway is an important and evolutionarily conserved signaling system involved in the development of multicellular organisms. Notch signaling plays an important role in the regulation of proliferation and differentiation of many cell types. In this study, we report new aspects of Notch gene participation in oogenesis using our previously generated mutations. The mutations consist of an i ...
DOI:
10.3390/jdb10030032

13. NUMTs Can Imitate Biparental Transmission of mtDNA—A Case in Drosophila melanogaster

Author:
Maria-Eleni Parakatselaki; Chen-Tseh Zhu; David Rand; Emmanuel D. Ladoukakis
Source:
Genes 2022 v.13 no.6 pp. -
ISSN:
2073-4425
Subject:
Drosophila melanogaster,   etc   ; haplotypes; mitochondria; nuclear genome; sequence analysis; uncertainty;     Show all 6 Subjects
Abstract:
... mtDNA sequences can be incorporated into the nuclear genome and produce nuclear mitochondrial fragments (NUMTs), which resemble mtDNA in their sequence but are transmitted biparentally, like the nuclear genome. NUMTs can be mistaken as real mtDNA and may lead to the erroneous impression that mtDNA is biparentally transmitted. Here, we report a case of mtDNA heteroplasmy in a Drosophila melanogaste ...
DOI:
10.3390/genes13061023

14. What we have learnt from Drosophila model organism: the coordination between insulin signaling pathway and tumor cells

Author:
Tang Weina; Li Ying; Wang Yiwen; Qiao Huan-huan
Source:
Heliyon 2022 v.8 no.7 pp. e09957
ISSN:
2405-8440
Subject:
Drosophila melanogaster,   etc   ; carcinogenesis; glucose; homeostasis; insulin; models; neoplasms; therapeutics;     Show all 8 Subjects
Abstract:
... Cancer development is related to a variety of signaling pathways which mediate various cellular processes including growth, survival, division and competition of cells, as well as cell-cell interaction. The insulin signaling pathway interacts with different pathways and plays a core role in the regulations of all these processes. In this study, we reviewed recent studies on the relationship betwee ...
DOI:
10.1016/j.heliyon.2022.e09957

15. Molecular physiology of iron trafficking in Drosophila melanogaster

Author:
Shitao Wu; Sai Yin; Bing Zhou
Source:
Current opinion in insect science 2022 v.50 pp. 100888
ISSN:
2214-5745
Subject:
Drosophila melanogaster,   etc   ; ferritin; homeostasis; insects; iron; iron absorption; transferrin;     Show all 7 Subjects
Abstract:
... Iron homeostasis in insects is less-well understood comparatively to mammals. The classic model organism Drosophila melanogaster has been recently employed to explore how iron is trafficked between and within cells. An outline for iron absorption, systemic delivery, and efflux is thus beginning to emerge. The proteins Malvolio, ZIP13, mitoferrin, ferritin, transferrin, and IRP-1A are key players i ...
DOI:
10.1016/j.cois.2022.100888

16. A conserved node in the regulation of Vasa between an induced and an inherited program of primordial germ cell specification

Author:
Margherita Perillo; S. Zachary Swartz; Gary M. Wessel
Source:
Developmental biology 2022 v.482 pp. 28-33
ISSN:
0012-1606
Subject:
Drosophila melanogaster,   etc   ; cell specificity; early development; gastrulation; germ cells;     Show all 5 Subjects
Abstract:
... Primordial germ cells (PGCs) are specified by diverse mechanisms in early development. In some animals, PGCs are specified via inheritance of maternal determinants, while in others, in a process thought to represent the ancestral mode, PGC fate is induced by cell interactions. Although the terminal factors expressed in specified germ cells are widely conserved, the mechanisms by which these factor ...
DOI:
10.1016/j.ydbio.2021.11.007

17. The Peptide Hormone CNMa Influences Egg Production in the Mosquito Aedes aegypti

Author:
Nia I. Keyes-Scott; Aryan Lajevardi; Kyle R. Swade; Mark R. Brown; Jean-Paul Paluzzi; Kevin J. Vogel
Source:
Insects 2022 v.13 no.3 pp. -
ISSN:
2075-4450
Subject:
Drosophila melanogaster,   etc   ; Aedes aegypti; egg production; evolution; females; males; peptides;     Show all 7 Subjects
Abstract:
... Mosquito reproduction is regulated by a suite of hormones, many acting through membrane-bound receptor proteins. The Aedes aegypti G protein-coupled receptors AAEL024199 (AeCNMaR-1a) and AAEL018316 (AeCNMaR-1b) were identified as orthologs of the Drosophila melanogaster CNMa receptor (DmCNMaR). The receptor was duplicated early in the evolution of insects, and subsequently in Culicidae, into what ...
DOI:
10.3390/insects13030230

18. Genomic and functional conservation of lncRNAs: lessons from flies

Author:
Carlos Camilleri-Robles; Raziel Amador; Cecilia C. Klein; Roderic Guigó; Montserrat Corominas; Marina Ruiz-Romero
Source:
Mammalian genome 2022 v.33 no.2 pp. 328-342
ISSN:
0938-8990
Subject:
Drosophila melanogaster,   etc   ; DNA; fruit flies; genetic distance; genome; genomics; humans; mice;     Show all 8 Subjects
Abstract:
... Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically, and often lowly, expressed in certain tissues, cell types and biological contexts. Although lncRNAs participate in the regulation of a wide variety of biological processes, including development and disease, most of th ...
DOI:
10.1007/s00335-021-09939-4

19. Lack of evidence for conserved parasegmental grooves in arthropods

Author:
Ralf Janssen; Natascha Turetzek; Matthias Pechmann
Source:
Development genes and evolution 2022 v.232 no.1 pp. 27-37
ISSN:
0949-944X
Subject:
Drosophila melanogaster,   etc   ; Cupiennius salei; Phalangium opilio; evolution; gene expression; genes; spiders;     Show all 7 Subjects
Abstract:
... In the arthropod model species Drosophila melanogaster, a dipteran fly, segmentation of the anterior–posterior body axis is under control of a hierarchic gene cascade. Segmental boundaries that form morphological grooves are established posteriorly within the segmental expression domain of the segment-polarity gene (SPG) engrailed (en). More important for the development of the fly, however, are t ...
DOI:
10.1007/s00427-022-00684-5

20. Drosophila Glue: A Promising Model for Bioadhesion

Author:
Manon Monier; Virginie Courtier-Orgogozo
Source:
Insects 2022 v.13 no.8 pp. -
ISSN:
2075-4450
Subject:
Drosophila melanogaster,   etc   ; bioadhesion; bioadhesives; excretion; genes; glycosylation; metamorphosis; models; mucoproteins; predation;     Show all 10 Subjects
Abstract:
... The glue produced by Drosophila larvae to attach themselves to a substrate for several days and resist predation until the end of metamorphosis represents an attractive model to develop new adhesives for dry environments. The adhesive properties of this interesting material have been investigated recently, and it was found that it binds as well as strongly adhesive commercial tapes to various type ...
DOI:
10.3390/insects13080734