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1. Phylogenetic analysis of infectious bronchitis virus circulating in southern China in 2016–2017 and evaluation of an attenuated strain as a vaccine candidate

Author:
Du, Haoyun,   et al.   ; Chen, Libin; Xiang, Bin; Hong, Yanfen; Li, Qian; Lin, Qiuyan; Liao, Ming; Ren, Tao; Xu, Chenggang;     Show all 9 Authors
Source:
Archives of virology 2021 v.166 no.1 pp. 73-81
ISSN:
0304-8608
Subject:
Infectious bronchitis virus; chicken eggs; chickens; farms; genotype; infection; infectious bronchitis; live vaccines; phylogeny; poultry industry; protective effect; respiratory tract diseases; safety testing; signs and symptoms (animals and humans); specific pathogen-free animals; strains; viral shedding; virology; China
Abstract:
... Avian infectious bronchitis (IB) is a highly contagious viral respiratory disease, caused by infectious bronchitis virus (IBV), that poses an important economic threat to the poultry industry. In recent years, genotypes GI-7, GI-13, and GI-19 have been the most prevalent IBV strains in China. However, in this study, we found that most IBV strains from southern China in 2016–2017 belonged to genoty ...
DOI:
10.1007/s00705-020-04851-9

2. Newcastle disease virus RNA-induced IL-1β expression via the NLRP3/caspase-1 inflammasome

Author:
Du, Haoyun,   et al.   ; Gao, Pei; Chen, Libin; Fan, Lei; Ren, Jinlian; Sun, Minhua; Li, Yaling; Xie, Peng; Lin, Qiuyan; Liao, Ming; Xu, Chenggang; Ning, Zhangyong; Ding, Chan; Xiang, Bin; Ren, Tao;     Show all 15 Authors
Source:
Veterinary research 2020 v.51 no.1 pp. 53
ISSN:
1297-9716
Subject:
Avian orthoavulavirus 1; Newcastle disease; RNA; body temperature; caspase-1; cell culture; chickens; inflammasomes; inflammation; interleukin-1beta; mortality; neutralizing antibodies; pathogenesis; ultracentrifugation; virulence; China
Abstract:
... Newcastle disease virus (NDV) infection causes severe inflammation and is a highly contagious disease in poultry. Virulent NDV strains (GM) induce large quantities of interleukin-1β (IL-1β), which is the central mediator of the inflammatory reaction. Excessive expression of IL-1β exacerbates inflammatory damage. Therefore, exploring the mechanisms underlying NDV-induced IL-1β expression can aid in ...
DOI:
10.1186/s13567-020-00774-0
PubMed:
32293543
PubMed Central:
PMC7156904