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- Duffus, Kate, et al. Show all 18 Authors
- Genome biology 2016 v.17 no.1 pp. 212
- B-lymphocytes; DNA fragmentation; T-lymphocytes; alleles; autoimmunity; chromatin; genome-wide association study; loci; monoclonal antibodies; psoriasis; rheumatoid arthritis; risk; single nucleotide polymorphism; therapeutics; transcription factor NF-kappa B; translation (genetics)
- ... BACKGROUND: The identification of causal genes from genome-wide association studies (GWAS) is the next important step for the translation of genetic findings into biologically meaningful mechanisms of disease and potential therapeutic targets. Using novel chromatin interaction detection techniques and allele specific assays in T and B cell lines, we provide compelling evidence that redefines causa ...