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- Durno, Laura, et al. Show all 11 Authors
- Analytical chemistry 2019 v.91 no.14 pp. 8908-8917
- hemagglutinins; immunization; influenza vaccines; neutralizing antibodies; reversed-phase high performance liquid chromatography; sialic acid
- ... Influenza vaccine potency is determined by the quantification of immunologically active hemagglutinin capable of eliciting neutralizing antibodies upon immunization. Currently, the single radial immunodiffusion (SRID) method is the standard in vitro potency assay used for lot release of seasonal inactivated influenza vaccines. Despite the proven usage of SRID, significant limitations such as the t ...
- Durno, Laura, et al. Show all 8 Authors
- Journal of chromatography 2017
- Influenza B virus; antigens; hemagglutinins; influenza; influenza vaccines; quantitative analysis; reversed-phase high performance liquid chromatography; surfactants; vaccination
- ... Seasonal inactivated quadrivalent influenza vaccines are currently formulated to include antigens from two strains of influenza A and a strain from each of the two circulating influenza B virus lineages. However, the applicability of the potency assay currently required for the release of vaccines has been hindered due to cross-reactivity between the two B strains. In this study, a reversed-phase ...