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- Eckert, Carrie A., et al. Show all 8 Authors
- Metabolic engineering 2019 v.51 pp. 50-58
- diploidy; ethanol; gene expression; glucose tolerance; mutants; mutation; phenotype; regulator genes; synthetic biology; yeasts
- ... Multiplex navigation of global regulatory networks (MINR) is an approach for combinatorially reprogramming gene expression to manipulate complex phenotypes. We designed, constructed, and mapped MINR libraries containing 43,020 specific mutations in 25 regulatory genes expected to perturb the yeast regulatory network. We selected growth competition experiments for library mutants conferring increas ...