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- Egido, Jesús, et al. Show all 10 Authors
- Molecular and cellular endocrinology 2018 v.474 pp. 10-19
- adipocytes; adipose tissue; agonists; animal disease models; bombesin receptors; diabetes; gene expression; genes; glucose; homeostasis; humans; insulin; lipogenesis; mitogen-activated protein kinase; mutation; obesity; patients; protein content; protein synthesis; rats; skeletal muscle; therapeutics
- ... BRS-3 has an important role in glucose homeostasis. Its expression was reduced in skeletal muscle from obese and/or diabetic patients, and BRS-3 KO-mice developed obesity. In this work, focused on rat/human adipose tissue, BRS-3 gene-expression was lower than normal-levels in hyperlipidemic, type-2-diabetic (T2D), and type-1-diabetic rats and also in obese (OB) and T2D patients. Moreover, BRS-3 pr ...
- Egido, Jesus, et al. Show all 9 Authors
- Environmental toxicology 2018 v.33 no.3 pp. 325-332
- NAD(P)H oxidase (H2O2-forming); acute exposure; adenosine triphosphate; antioxidant activity; apoptosis; bisphenol A; calcium; cell viability; confocal microscopy; energy; enzyme activity; epithelial cells; flow cytometry; gene expression; heme oxygenase (biliverdin-producing); humans; kidney diseases; mitochondria; nephrotoxicity; oxidative stress; oxygen consumption; p-cresol; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; toxins
- ... BACKGROUND: Uremic toxins that accumulate in chronic kidney disease (CKD) contribute to CKD complications, such as CKD progression. Bisphenol A (BPA) is a ubiquitous environmental toxin, structurally related with p‐cresol, that accumulates in CKD. Our aim was to characterize the nephrotoxic potential of BPA. Specifically, we addressed BPA toxicity over energy‐demanding proximal tubular cells. METH ...
- Egido, Jesús, et al. Show all 13 Authors
- adults; anti-inflammatory activity; bile acids; body weight; gamma-glutamyltransferase; glucose; inflammation; lipid composition; liver function; low density lipoprotein cholesterol; metabolism; normal values; parenteral feeding; patients; protective effect; taurine
- ... Background: Taurine’s role in bile acid metabolism and anti-inflammatory activity could exert a protective effect on hepatobiliary complications associated with parenteral nutrition (PN). In this study, the effects of 2 amino acid solutions, with and without taurine, on liver function administered to nonacutely ill postsurgical patients as part of a short-term PN regimen were prospectively compare ...