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Hepatitis C virus; fibrosis; liver transplant; odds ratio
Abstract:
... Liver transplantation for hepatitis C virus (HCV)-related disease has the lowest five-year graft survival among all liver transplant recipients. Graft failure due to accelerated fibrosis from unrestrained HCV replication is common. Optimal timing of HCV treatment with direct-acting antiviral agents remains unknown. We compared HCV liver transplant recipients successfully treated for HCV before tra ...
females; lizards; males; paternity; progeny; sexual selection; sperm competition
Abstract:
... Sexual selection theory predicts different optima for multiple mating in males and females. We used mating experiments and genetic paternity testing to disentangle pre- and postcopulatory mechanisms of sexual selection and alternate reproductive tactics in the highly promiscuous lizard Eulamprus heatwolei. Both sexes mated multiply: 30–60 % of clutches were sired by two to four fathers, depending ...
chemical communication; chemical reactions; dendrimers; drugs; lipoic acid; oxidative stress; temperature; therapeutics; thermosensitivity
Abstract:
... A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated at the periphery of the thermosensitive dendrimer formulations undergoes slow and sustained release at 37–42 °C, and rescues the cells from oxidative stress and a pro-inflammatory endotoxic agent. ...