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- Erlich-Hadad, Tal, et al. Show all 7 Authors
- The international journal of biochemistry & cell biology 2016 v.81 pp. 48-56
- aconitate hydratase; adenosine triphosphate; ataxia (disorder); cell viability; citrate (si)-synthase; humans; mitochondria; nuclear-encoded proteins; open reading frames; oxidative stress; patients
- ... Mitochondrial Targeting Sequences (MTSs) are responsible for trafficking nuclear-encoded proteins into mitochondria. Once entering the mitochondria, the MTS is recognized and cleaved off. Some MTSs are long and undergo two-step processing, as in the case of the human frataxin (FXN) protein (80aa), implicated in Friedreich's ataxia (FA). Therefore, we chose the FXN protein to examine whether nuclea ...