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- Feißt, Andreas, et al. Show all 9 Authors
- Life sciences 2018 v.215 pp. 96-105
- animal models; apoptosis; cannabinoids; cardiomyocytes; collagen; enzymes; hemodynamics; hypertension; hypertrophy; immunohistochemistry; inflammation; interleukin-10; ischemia; long term effects; lungs; macrophages; messenger RNA; mice; myosin; organ transplantation; protective effect; pulmonary artery
- ... Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. Therefore, we investigated the role of CB2 receptor in RV adaptation after occlusion of the left pulmonary artery (L ...
- Feisst, Andreas, et al. Show all 8 Authors
- Life sciences 2014 v.102 no.2 pp. 88-97
- Western blotting; antioxidant activity; apoptosis; beta oxidation; cardiomyocytes; cytokines; echocardiography; females; fibrosis; glucose; glycogen; histology; inflammation; lipotoxicity; macrophages; males; mice; myosin heavy chains; peroxisome proliferator-activated receptors
- ... Peroxisome proliferator-activated receptor (PPAR)-α is downregulated in ischemic myocardium resulting in substrate switch from fatty acid oxidation to glucose utilization. Pharmacological PPAR-α activation leads to increased fatty acid oxidation and myocardial lipotoxicity. The aim of our study was to investigate the role of cardiomyocyte specific PPAR-α overexpression in myocardial adaptation to ...