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- Feng, Yangmeng, et al. Show all 9 Authors
- Biochemical and biophysical research communications 2019 v.513 no.2 pp. 446-451
- Orthomyxoviridae; Western blotting; antigens; bacteria; cross reaction; hemagglutinins; humans; insulin-dependent diabetes mellitus; islets of Langerhans; mass spectrometry; monoclonal antibodies; pathogenesis; rats; transfection
- ... Influenza virus infection is associated with type 1 diabetes (T1DM), but its pathogenesis remains unclear. Here, our study found that one of the monoclonal antibodies against H1N1 influenza virus hemagglutinin(HA) cross-reacted with human pancreatic tissue and further demonstrated that it binded to rat islet β-cells. We immunoprecipitated islet protein with this cross-reactive antibody and identif ...