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- Fierro, Camino, et al. Show all 6 Authors
- P-glycoproteins; biopsy; carcinogenesis; cats; duodenum; endoscopy; gene expression; genes; histology; histopathology; homeostasis; inflammatory bowel disease; lymphoma; messenger RNA; multiple drug resistance; prostaglandin synthase; prostaglandins; quantitative polymerase chain reaction; signs and symptoms (animals and humans); spaying
- ... Multidrug resistance 1 (MDR1) encodes a protein called P-glycoprotein (P-gp), which serves as an efflux pump membrane protein implicated in intestinal homeostasis and drug resistance. Cyclooxygenase-2 (COX2) is a key enzyme in the synthesis of proinflammatory prostaglandins, tumourigenesis and in mucosal defence. Despite the importance of MDR1 and COX2, changes in their mRNA levels have not been s ...