Jump to Main Content
- Firsanov, Denis, et al. Show all 28 Authors
- Cell 2019 v.177 no.3 pp. 622-638.e22
- DNA repair; accelerated aging; amino acids; evolution; longevity; mice; mutants; phenotype; solar radiation
- ... DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel of 18 rodent species with diverse lifespans, we show that more robust DNA double-strand break (DSB) repair, but not nucleotide excision repair (NER), coevolves with longevity. Evolution of NER, unlike DSB, is shaped prim ...
- Firsanov, Denis, et al. Show all 4 Authors
- Biochimie 2012 v.94 no.11 pp. 2416-2422
- DNA damage; DNA repair; Mesocricetus auratus; X-radiation; brain; chromatin; fibroblasts; fluorescence; fluorescence microscopy; genes; hamsters; heart; histones; humans; immunoblotting; immunohistochemistry; irradiation; kidneys; liver; mice; phosphorylation
- ... Phosphorylation of the replacement histone H2AX occurs in megabase chromatin domains around DNA double-strand breaks (DSBs), and this modification called γH2AX can be used as an effective marker for DSB repair and DNA damage response. In this study, we examined a bystander effect (BE) in locally irradiated embryonic human fibroblasts. Using fluorescence microscopy, we found that BE could be observ ...