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- Florang, Virginia R., et al. Show all 5 Authors
- Biochemical and biophysical research communications 2017
- Parkinson disease; aldehydes; catechol; dopamine; enzyme activity; glyceraldehyde-3-phosphate dehydrogenase; metabolites; moieties; neurotoxins; polyacrylamide gel electrophoresis
- ... The aldehyde metabolite of dopamine, 3,4-dihydroxyphenylacetaldehyde (DOPAL) is an endogenous neurotoxin implicated in Parkinson's Disease. Elucidating protein targets of DOPAL is essential in understanding it's pathology. The enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a target of DOPAL.GAPDH activity was measured via reduction of NAD+ cofactor (340 nm). Protein aggregation was as ...
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