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You searched for: Subject "Food and Drug Administration" Remove constraint Subject: "Food and Drug Administration"
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1. Pyridine: the scaffolds with significant clinical diversity

Author:
Sourav De; Ashok Kumar S K; Suraj Kumar Shah; Sabnaz Kazi; Nandan Sarkar; Subhasis Banerjee; Sanjay Dey
Source:
RSC advances 2022 v.12 no.24 pp. 15385-15406
ISSN:
2046-2069
Subject:
Food and Drug Administration,   etc   ; drugs; moieties; pyridines;     Show all 4 Subjects
Abstract:
... The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an important position as a precious source of clinically useful agents in the field of medicinal chemistry research. This privileged scaffold has been consistently incorporated in a diverse range of drug candidates approved by the FDA (Food and Drug Administration). This moiety has attracted increasing attention from ...
DOI:
10.1039/d2ra01571d

2. Pathogen Reduction for Platelets—A Review of Recent Implementation Strategies

Author:
Paolo Rebulla; Daniele Prati
Source:
Pathogens 2022 v.11 no.2 pp. -
ISSN:
2076-0817
Subject:
Food and Drug Administration,   etc   ; adults; humans; medicine; pathogens; risk;     Show all 6 Subjects
Abstract:
... The development of pathogen reduction technologies (PRT) for labile blood components is a long-pursued goal in transfusion medicine. While PRT for red blood cells and whole blood are still in an early phase of development, different PRT platforms for plasma and platelets are commercially available and routinely used in several countries. This review describes complementary strategies recommended b ...
DOI:
10.3390/pathogens11020142

3. Physico-chemical properties of aluminum adjuvants in vaccines: Implications for toxicological evaluation

Author:
Ghidaa Badran; Loïc Angrand; Jean-Daniel Masson; Guillemette Crépeaux; Marie-Odile David
Source:
Vaccine 2022 v.40 no.33 pp. 4881-4888
ISSN:
0264-410X
Subject:
Food and Drug Administration,   etc   ; adjuvants; aluminum; humans; toxicity testing; vaccines;     Show all 6 Subjects
Abstract:
... Aluminum salts have been used as adjuvants in human vaccines since 1932. The most used adjuvants are Al oxyhydroxide (AlOOH) and Al hydroxyphosphate (AlOHPO₄). Al adjuvants have different physico-chemical properties. The differences in these properties are not well documented and not considered by the Food and Drug Administration (FDA), though they can largely influence biological effects of the a ...
DOI:
10.1016/j.vaccine.2022.06.064

4. Nucleic acid-based therapy for brain cancer: Challenges and strategies

Author:
Zixia Zhang; João Conniot; Joana Amorim; Yiliang Jin; Rajendra Prasad; Xiyun Yan; Kelong Fan; João Conde
Source:
Journal of controlled release 2022 v.350 pp. 80-92
ISSN:
0168-3659
Subject:
Food and Drug Administration,   etc   ; brain; brain neoplasms; nucleic acids; therapeutics;     Show all 5 Subjects
Abstract:
... Nucleic acid-based therapy emerges as a powerful weapon for the treatment of tumors thanks to its direct, effective, and lasting therapeutic effect. Encouragingly, continuous nucleic acid-based drugs have been approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Despite the tremendous progress, there are few nucleic acid-based drugs for brain tumors in clinic ...
DOI:
10.1016/j.jconrel.2022.08.014

5. Effects of carrier solutions on the viability and efficacy of canine adipose-derived mesenchymal stem cells

Author:
Tania Sultana; Ahmed Abdal Dayem; Soo Bin Lee; Ssang-Goo Cho; Jeong Ik Lee
Source:
BMC veterinary research 2022 v.18 no.1 pp. 26
ISSN:
1746-6148
Subject:
Food and Drug Administration,   etc   ; dogs; glucose; heparin; therapeutics; veterinary medicine; viability;     Show all 7 Subjects
Abstract:
... BACKGROUND: Mesenchymal stem cells (MSCs) have favorable characteristics that render them a potent therapeutic tool. We tested the characteristics of MSCs after temporal storage in various carrier solutions, such as 0.9% saline (saline), 5% dextrose solution (DS), heparin in saline, and Hartmann’s solution, all of which are approved by the U.S. Food and Drug Administration (FDA). Phosphate-buffere ...
DOI:
10.1186/s12917-021-03120-4

6. Estimating vaccine efficacy over time after a randomized study is unblinded

Author:
Anastasios A. Tsiatis; Marie Davidian
Source:
Biometrics 2022 v.78 no.3 pp. 825-838
ISSN:
0006-341X
Subject:
Food and Drug Administration,   etc   ; COVID-19 infection; ethics; placebos; vaccines; viruses;     Show all 6 Subjects
Abstract:
... The COVID‐19 pandemic due to the novel coronavirus SARS CoV‐2 has inspired remarkable breakthroughs in the development of vaccines against the virus and the launch of several phase 3 vaccine trials in Summer 2020 to evaluate vaccine efficacy (VE). Trials of vaccine candidates using mRNA delivery systems developed by Pfizer‐BioNTech and Moderna have shown substantial VEs of 94–95%, leading the US F ...
DOI:
10.1111/biom.13509

7. Translation of aptamers toward clinical diagnosis and commercialization

Author:
Shan Liu; Yixin Xu; Xin Jiang; Hong Tan; Binwu Ying
Source:
Biosensors & bioelectronics 2022 v.208 pp. 114168
ISSN:
0956-5663
Subject:
Food and Drug Administration,   etc   ; biosensors; commercialization; diagnostic techniques; drugs; immunogenicity; manufacturing; oligonucleotides;     Show all 8 Subjects
Abstract:
... The dominance of antibodies in diagnostics has gradually changed following the discovery of aptamers in the early 1990s. Aptamers offer inherent advantages over traditional antibodies, including higher specificity, higher affinity, smaller size, greater stability, ease of manufacture, and low immunogenicity, rendering them the best candidates for point-of-care testing (POCT). In the past 20 years, ...
DOI:
10.1016/j.bios.2022.114168

8. Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery

Author:
Masatoshi Maeki; Shuya Uno; Ayuka Niwa; Yuto Okada; Manabu Tokeshi
Source:
Journal of controlled release 2022 v.344 pp. 80-96
ISSN:
0168-3659
Subject:
Food and Drug Administration,   etc   ; COVID-19 infection; lipids; microfluidic technology; nanomedicine; therapeutics;     Show all 6 Subjects
Abstract:
... In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug Administration. mRNA vaccines are important for preventing severe COVID-19 and returning to normal life. The development of RNA-delivery technology, including mRNA vaccines, has been investigated worldwide for ~30 years. Lipid nanoparticles (LNPs) are a breakthrough technology that stably delivers RNA to target organs, and ...
DOI:
10.1016/j.jconrel.2022.02.017

9. Implementing FAIR data management practices in shellfish sanitation

Author:
Natalie G. Nelson; Jeremy Cothran; Dan Ramage; Megan Carr; Keith Skiles; Dwayne E. Porter
Source:
Aquaculture reports 2022 v.26 pp. 101324
ISSN:
2352-5134
Subject:
Food and Drug Administration,   etc   ; databases; humans; information management; mariculture; sanitation; shellfish; water quality;     Show all 8 Subjects
Abstract:
... In the United States (U.S.), state agencies in charge of mariculture regulation are mandated under the U.S. Food and Drug Administration’s (FDA) National Shellfish Sanitation Program (NSSP) to monitor fecal indicator bacteria (FIB) concentrations, commonly of fecal coliforms, to determine the safety of coastal waters for supporting harvestable shellfish for human consumption. Many states have moni ...
DOI:
10.1016/j.aqrep.2022.101324

10. Salmonella Enteritidis Outbreaks Associated with Egg-Producing Farms Not Regulated by Food and Drug Administration's Egg Safety Rule

Author:
Charles Robert Stilz; Steffany Cavallo; Katie Garman; John R. Dunn
Source:
Foodborne pathogens & disease 2022 v.19 no.8 pp. 529-534
ISSN:
1556-7125
Subject:
Food and Drug Administration,   etc   ; Salmonella Enteritidis; eggs; farms; food safety; risk; salmonellosis; Tennessee;     Show all 8 Subjects
Abstract:
... The Food and Drug Administration Egg Safety Rule requires producers with >3000 layer hens to register a Salmonella enterica serotype Enteritidis (SE) prevention plan for production, storage, and transport of shell eggs. Since its implementation began in 2010, four outbreaks of egg-associated salmonellosis have occurred in Tennessee. We reviewed state health department records from each outbreak an ...
DOI:
10.1089/fpd.2022.0025

11. Carcinogenic components of tobacco and tobacco smoke: A 2022 update

Author:
Yupeng Li; Stephen S. Hecht
Source:
Food and chemical toxicology 2022 v.165 pp. 113179
ISSN:
0278-6915
Subject:
Food and Drug Administration,   etc   ; analytical methods; carcinogenicity; human health; monitoring; smoke; tobacco; toxicology;     Show all 8 Subjects
Abstract:
... Tobacco and tobacco smoke contain a complex mixture of over 9500 chemical compounds, many of which have been recognized as hazardous to human health by regulatory agencies. In 2012, the U.S. Food and Drug Administration established a list of harmful and potentially harmful constituents in unburned tobacco and tobacco smoke, 79 of which are considered as carcinogens. Over the past 10 years, with ad ...
DOI:
10.1016/j.fct.2022.113179

12. Current review of isoxazoline ectoparasiticides used in veterinary medicine

Author:
Xueying Zhou; Alexandra E. Hohman; Walter H. Hsu
Source:
Journal of veterinary pharmacology and therapeutics 2022 v.45 no.1 pp. 1-15
ISSN:
0140-7783
Subject:
Food and Drug Administration,   etc   ; chlorides; ectoparasiticides; nervous system; pharmacodynamics; pharmacokinetics; therapeutics; veterinary medicine;     Show all 8 Subjects
Abstract:
... The isoxazolines are a novel class of ectoparasiticides with potent inhibitory activity on glutamate‐ and gamma‐aminobutyric acid‐gated chloride channel located in nervous system of invertebrates. In recent years, studies have been performed to evaluate the efficacy and safety of isoxazolines against various types of ectoparasites, including fleas, ticks, and mites. As more single and combined iso ...
DOI:
10.1111/jvp.12959

13. A New Method for Calculating Calcium Content and Determining Appropriate Calcium Levels in Foods

Author:
Abed Forouzesh; Fatemeh Forouzesh; Sadegh Samadi Foroushani; Abolfazl Forouzesh; Eskandar Zand
Source:
Food analytical methods 2022 v.15 no.1 pp. 16-25
ISSN:
1936-9751
Subject:
Food and Drug Administration,   etc   ; Codex Alimentarius; calcium; calcium deficiency; energy; energy content; obesity;     Show all 7 Subjects
Abstract:
... The calcium content of some foods is inappropriately calculated per 100 kcal, 100 g or 100 mL, or the reference amount customarily consumed (RACC). So, making some food choices based on them to achieve adequate calcium may increase the risks of some chronic diseases. Calculating the calcium content and determining appropriate calcium levels based on the US Food and Drug Administration (FDA), the C ...
DOI:
10.1007/s12161-021-02084-3

14. Decomposing Aflatoxins in Peanuts Using Advanced Oxidation Processes by UV and H2O2

Author:
Ming-Hsun Shen; Rakesh K. Singh
Source:
Food and bioprocess technology 2022 v.15 no.7 pp. 1647-1657
ISSN:
1935-5130
Subject:
Food and Drug Administration,   etc   ; aflatoxins; bioprocessing; color; fungi; oils; oxidation; peanuts; photolysis; ultraviolet radiation;     Show all 10 Subjects
Abstract:
... The advanced oxidation processes (AOP) employ free radicals generated from the photolysis of H₂O₂ by UV radiation to decompose the contamination in foods. This study aims at applying AOP to reduce the aflatoxins in peanuts. Radiations in UV-C or UV-A range combined with H₂O₂ solution efficiently degraded aflatoxins in the model solution. The degradation compound, aflatoxin B2a, was also degraded b ...
DOI:
10.1007/s11947-022-02844-x

15. Development and application of a chromatographic method for simultaneous quantification of 5-fluorouracil and imiquimod in drug-in-adhesive topical patches

Author:
Sangseo Kim; Souha H. Youssef; Yunmei Song; Sanjay Garg
Source:
Sustainable chemistry and pharmacy 2022 v.27 pp. 100711
ISSN:
2352-5541
Subject:
Food and Drug Administration,   etc   ; acetonitrile; chromatography; fluorouracil; green chemistry; pH; skin neoplasms; sodium acetate;     Show all 8 Subjects
Abstract:
... Topical patches containing 5-fluorouracil and imiquimod would significantly improve the shortcomings of the marketed semi-solid formulations for the treatment of non-melanoma skin cancer. As an analytical method is a fundamental part of formulation development, in this study, a simple, accurate, sensitive and greener analytical method was developed and validated for the simultaneous quantification ...
DOI:
10.1016/j.scp.2022.100711

16. Alzheimer's disease failed clinical trials

Author:
Shreya Asher; Ronny Priefer
Source:
Life sciences 2022 v.306 pp. 120861
ISSN:
0024-3205
Subject:
Food and Drug Administration,   etc   ; Alzheimer disease; amyloid; antibodies; cognition; cognitive disorders; memory disorders; neurodegenerative diseases;     Show all 8 Subjects
Abstract:
... Alzheimer's disease is a progressive neurodegenerative disease typically presenting with symptoms of memory loss and cognitive decline. Existing theories for the causation of this focuses on amyloid beta plaques and neurofibrillary tau tangles. Most US Food and Drug Administration approved therapies for Alzheimer's disease target cognitive function. A multitude of clinical trials, with a variety o ...
DOI:
10.1016/j.lfs.2022.120861

17. Clinical evaluation of bempedoic acid for the treatment of hyperlipidaemia

Author:
Maurizio Averna; Claudio Bilato; Giorgio Sesti; the Italian Clinical Network on Bempedoic Acid
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.1 pp. 17-20
ISSN:
0939-4753
Subject:
Food and Drug Administration,   etc   ; clinical examination; hyperlipidemia; lipids; meta-analysis; metabolism; nutrition; risk; therapeutics; Europe;     Show all 10 Subjects
Abstract:
... Bempedoic acid (BA) is a novel first-in-class oral lipid-lowering therapy. BA has been approved by the European Medicinal Agency and Food and Drug Administration and has been commercialised throughout Europe since the end of 2020 as an add-on therapy in patients at high/very-high cardiovascular risk that are not at LDL-C goals with current lipid-lowering treatments. Recently, Italian lipid managem ...
DOI:
10.1016/j.numecd.2021.09.023

18. Makisterone A attenuates experimental cholestasis by activating the farnesoid X receptor

Author:
Peiyuan Kang; Sha Li
Source:
Biochemical and biophysical research communications 2022 v.623 pp. 162-169
ISSN:
0006-291X
Subject:
Food and Drug Administration,   etc   ; bile; cholestasis; databases; excretion; liver; metabolism; mice; research; secretion; ursodeoxycholic acid;     Show all 11 Subjects
Abstract:
... Cholestasis is the accumulation of bile acids in the liver due to impaired bile formation, secretion, and excretion caused by infections, drugs, metabolic or genetic diseases. Ursodeoxycholic acid is the only drug approved by the Food and Drug Administration for the treatment of primary biliary cholangitis, but nearly 40% of patients do not adequately respond to this drug and 5–10% show intoleranc ...
DOI:
10.1016/j.bbrc.2022.07.030

19. An Overview of Hepatocellular Carcinoma with Emphasis on Dietary Products and Herbal Remedies

Author:
Deepa S. Mandlik; Satish K. Mandlik
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1549-1567
ISSN:
1532-7914
Subject:
Food and Drug Administration,   etc   ; cancer therapy; chemical constituents of plants; drugs; etiology; hepatoma; nutrition; toxicity;     Show all 8 Subjects
Abstract:
... The most common principal malignant tumor that accounts for ∼80% of cases of liver cancer across the world is hepatocellular carcinoma (HCC). It is a multifacetedillness that is caused by several risk factors and often progresses in the context of underlying cirrhosis. It is tremendously difficult and essential for the screening of novel therapeutic medications to establish HCC preclinical models ...
DOI:
10.1080/01635581.2021.1965630

20. Potentially toxic elements contamination and its removal by aquatic weeds in the riverine system: A comparative approach

Author:
Arisekar Ulaganathan; Jeya Shakila Robinson; Shalini Rajendran; Jeyasekaran Geevaretnam; Sundhar Shanmugam; Arumugam Natarajan; Almansour Abdulrahman I; Perumal Karthikeyan
Source:
Environmental research 2022 v.206 pp. 112613
ISSN:
0013-9351
Subject:
Food and Drug Administration,   etc   ; guidelines; hybridization; hyperaccumulators; phytoaccumulation; research; riparian areas; rivers; sediments; sewage; toxicity; India;     Show all 12 Subjects
Abstract:
... Thamirabarani river acquires large untreated sewage effluents from the Tirunelveli and Thoothukudi districts of South Tamil Nadu. This study examined the concentration of trace elements in water, sediment, and phytoaccumulation potential of aquatic weeds viz., A. cristata, E. crassipes, S. natans, and P. stratiotes, growing along Srivaikundam dam of Thamirabarani river. The Pb, As, Hg, Cd, and Ni ...
DOI:
10.1016/j.envres.2021.112613