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1. Environmental sampling for the detection of foot‐and‐mouth disease virus and peste des petits ruminants virus in a live goat market, Nepal

Author:
Claire Colenutt; Emma Brown; David J. Paton; Mana Mahapatra; Satya Parida; Noel Nelson; Jenny Maud; Paolo Motta; Keith Sumption; Bishnu Adhikari; Sharmila Chapagain Kafle; Mukul Upadhyaya; Samjana Kafle Pandey; Simon Gubbins
Source:
Transboundary and emerging diseases 2022 v.69 no.5 pp. 3041-3046
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; RNA; food security; goats; monitoring; wet markets; Nepal;     Show all 7 Subjects
Abstract:
... Livestock markets are considered vital parts of the agricultural economy, particularly in developing countries where livestock keeping contributes to both food security and economic stability. Animals from diverse sources are moved to markets, they mix while they are there and are subsequently redistributed over wide geographic areas. Consequently, markets provide an opportunity for targeted surve ...
DOI:
10.1111/tbed.14257

2. Rational design of novel fusion rabies glycoproteins displaying a major antigenic site of foot-and-mouth disease virus for vaccine applications

Author:
Ernesto Garay; Diego Fontana; Lautaro Leschiutta; Ricardo Kratje; Claudio Prieto
Source:
Applied microbiology and biotechnology 2022 v.106 no.2 pp. 579-592
ISSN:
0175-7598
Subject:
Foot-and-mouth disease virus,   etc   ; Lyssavirus; biotechnology; epitopes; glycoproteins; microbiology; models; rabies; vaccines;     Show all 9 Subjects
Abstract:
... Chimeric virus-like particles are self-assembling structures composed of viral proteins that had been modified to incorporate sequences from different organisms, being able to trigger immune responses against the heterologous sequence. However, the identification of suitable sites for that purpose in the carrier protein is not an easy task. In this work, we describe the generation of rabies chimer ...
DOI:
10.1007/s00253-021-11747-4

3. Establishing an In Vitro System to Assess How Specific Antibodies Drive the Evolution of Foot-and-Mouth Disease Virus

Author:
David J. King; Graham Freimanis; Chris Neil; Andrew Shaw; Tobias J. Tuthill; Emma Laing; Donald P. King; Lidia Lasecka-Dykes
Source:
Viruses 2022 v.14 no.8 pp. -
ISSN:
1999-4915
Subject:
Foot-and-mouth disease virus,   etc   ; cytopathogenicity; epitopes; evolution; immune system; phenotype; vaccination; viruses;     Show all 8 Subjects
Abstract:
... Viruses can evolve to respond to immune pressures conferred by specific antibodies generated after vaccination and/or infection. In this study, an in vitro system was developed to investigate the impact of serum-neutralising antibodies upon the evolution of a foot-and-mouth disease virus (FMDV) isolate. The presence of sub-neutralising dilutions of specific antisera delayed the onset of virus-indu ...
DOI:
10.3390/v14081820

4. Foot-and-Mouth Disease Virus 3Cpro Cleaves BP180 to Induce Blister Formation

Author:
Pathum Ekanayaka; Asela Weerawardhana; Kiramage Chathuranga; Jong-Hyeon Park; Jong-Soo Lee
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
Foot-and-mouth disease virus,   etc   ; enzyme activity; foot-and-mouth disease; mutants; proteinases;     Show all 5 Subjects
Abstract:
... Foot-and-mouth disease (FMD) is mainly characterized by blister formation (vesicles) in animals infected with foot-and-mouth disease virus (FMDV). However, the molecular basis of the blister formation in FMD is still unknown. BP180 is one of the main anchoring proteins connecting the dermal and epidermal layers of the skin. Previous studies have shown that the cleavage of BP180 by proteases produc ...
DOI:
10.3390/v14092060

5. Method for quantification of porcine type I interferon activity using luminescence, by direct and indirect means

Author:
Michael Puckette; J. Barrera; M. Schwarz; M. Rasmussen
Source:
BMC biotechnology 2022 v.22 no.1 pp. 13
ISSN:
1472-6750
Subject:
Foot-and-mouth disease virus,   etc   ; Vesiculovirus; antiviral properties; biotechnology; interferons; luciferase; luminescence; plasmids; secretion; swine;     Show all 10 Subjects
Abstract:
... BACKGROUND: Type I interferons are widely used in research applications and as biotherapeutics. Current assays used to measure interferon concentrations, such as plaque reduction assays and ELISA, are expensive, technically challenging, and may take days to provide results. We sought to develop a robust and rapid assay to determine interferon concentrations produced from transiently transfected ce ...
DOI:
10.1186/s12896-022-00743-9

6. One-step SYBR green-based real-time RT-PCR assay for detection of foot-and-mouth disease virus circulating in India

Author:
Jitendra K. Biswal; Biswa Ranjan Jena; Syed Zeeshan Ali; Rajeev Ranjan; Jajati K. Mohapatra; Rabindra Prasad Singh
Source:
Virus genes 2022 v.58 no.2 pp. 113-121
ISSN:
0920-8569
Subject:
Foot-and-mouth disease virus,   etc   ; RNA; agarose; cell culture; detection limit; diagnostic sensitivity; gels; viruses; India;     Show all 9 Subjects
Abstract:
... Rapid, sensitive, and reliable laboratory detection of foot-and-mouth disease virus (FMDV) infection is essential for containing and controlling virus infection in any geographical area. In this report a SYBR green-based 3Dᵖᵒˡ-specific one-step real-time RT-PCR (rRT-PCR) assay was developed for the pan-serotype detection of FMDV in India. The detection limit of the SYBR green-based rRT-PCR was 10⁻ ...
DOI:
10.1007/s11262-021-01884-3

7. Size exclusion chromatography using large pore size media induces adverse conformational changes of inactivated foot-and-mouth disease virus particles

Author:
Yanmin Song; Yanli Yang; Xuan Lin; Qizu Zhao; Zhiguo Su; Guanghui Ma; Songping Zhang
Source:
Journal of chromatography 2022 v.1677 pp. 463301
ISSN:
0021-9673
Subject:
Foot-and-mouth disease virus,   etc   ; animal tests; capsid; fluorescent dyes; gel chromatography; immunogenicity; porosity; thermal stability;     Show all 8 Subjects
Abstract:
... Size exclusion chromatography (SEC) of biomacromolecules using large pore size media and long column are usually necessary to obtain a satisfactory separation. However, the SEC separation of inactivated foot and mouth disease virus (FMDV) was found to induce some subtle but important conformational changes of FMDV in a pore-size and column length dependent manner. Here three Sephacryl media includ ...
DOI:
10.1016/j.chroma.2022.463301

8. Effect of cell density on the biological titer and yield of 146S fraction of foot-and-mouth disease virus O in cell suspension

Author:
Azka Rizvi; Nadir Hussain; Aftab Ahmed Anjum; Naveed Ahmed; Ayesha Naeem; Madiha Khan; Imran Altaf
Source:
Journal of virological methods 2022 v.300 pp. 114379
ISSN:
0166-0934
Subject:
Foot-and-mouth disease virus,   etc   ; cattle; cell viability; foot-and-mouth disease; meat; quality control; serotypes; vaccines; viruses; Pakistan;     Show all 10 Subjects
Abstract:
... Foot-and-mouth disease (FMD) is a highly infectious disease of cattle and other cloven-hoofed animals, causing huge economic losses annually worldwide. This disease is endemic in Pakistan where the serotypes of the foot-and-mouth disease virus (FMDV) are A, O and ASIA-1. At present, trivalent FMDV vaccines are being used to prevent FMD but the current production process is laborious and is unable ...
DOI:
10.1016/j.jviromet.2021.114379

9. Design of multiplexing lateral flow immunoassay for detection and typing of foot-and-mouth disease virus using pan-reactive and serotype-specific monoclonal antibodies: Evidence of a new hook effect

Author:
Simone Cavalera; Alida Russo; Efrem Alessandro Foglia; Santina Grazioli; Barbara Colitti; Sergio Rosati; Chiara Nogarol; Fabio Di Nardo; Thea Serra; Matteo Chiarello; Claudio Baggiani; Giulia Pezzoni; Emiliana Brocchi; Laura Anfossi
Source:
Talanta 2022 v.240 pp. 123155
ISSN:
0039-9140
Subject:
Foot-and-mouth disease virus,   etc   ; animals; cost effectiveness; epithelium; foot-and-mouth disease; immunoassays; ligands; livestock diseases; serotypes; trade; viruses;     Show all 11 Subjects
Abstract:
... The foot-and-mouth disease (FMD) is the most important transboundary viral disease of livestock in the international context, because of its extreme contagiousness, widespread diffusion, and severe impact on animal trade and animal productions. The rapid and on-field detection of the virus responsible for the FMD represents an urgent demand to efficiently control the diffusion of the infection, es ...
DOI:
10.1016/j.talanta.2021.123155

10. Diversity of SAT2 foot-and-mouth disease virus in Sudan: implication for diagnosis and control

Author:
Yazeed A/Raouf; Inas Ibrahim
Source:
Veterinary research communications 2022 v.46 no.3 pp. 789-798
ISSN:
0165-7380
Subject:
Foot-and-mouth disease virus,   etc   ; antibodies; cross immunity; genotyping; innate immunity; monitoring; neutralization; neutralization tests; vaccines; veterinary medicine; viruses; Sudan;     Show all 12 Subjects
Abstract:
... Like other East African countries, Sudan experienced circulation of more than one topotype of SAT2 foot-and-mouth disease virus (FMDV). In Sudan, topotype XIII of SAT2 virus was recorded in 1977 and 2008 and topotype VII in 2007, 2010, 2013, 2014 and 2017. This work evaluated the impact of such diversity on diagnosis and control. After one or three doses of a vaccine derived from a Sudanese SAT2 v ...
DOI:
10.1007/s11259-022-09899-3

11. A Naked-Eye Visual Reverse Transcription Loop-Mediated Isothermal Amplification with Sharp Color Changes for Potential Pen-Side Test of Foot-and-Mouth Disease Virus

Author:
Jie Zhang; Qian Hou; Weimin Ma; Danian Chen; Weibing Zhang; Ashenafi Kiros Wubshet; Yaozhong Ding; Miaomiao Li; Qian Li; Jiao Chen; Junfei Dai; Guohua Wu; Ziteng Zhang; Alexei D. Zaberezhny; Zygmunt Pejsak; Kazimierz Tarasiuk; Muhammad Umar Zafar Khan; Yang Wang; Jijun He; Yongsheng Liu
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
Foot-and-mouth disease virus,   etc   ; color; cross reaction; detection limit; livestock; reverse transcription; reverse transcription loop-mediated isothermal amplification; serotypes;     Show all 8 Subjects
Abstract:
... Visual loop-mediated isothermal amplification (LAMP) is qualified to be applied in the field to detect pathogens due to its simplicity, rapidity and cost saving. However, the color changes in currently reported visual reverse transcription LAMP (RT-LAMP) for foot-and-mouth disease virus (FMDV) detection are not so obvious to the naked eye, so interpretation of results is troublesome. In this study ...
DOI:
10.3390/v14091982

12. Evolutionary Dynamics of Foot and Mouth Disease Virus Serotype A and Its Endemic Sub-Lineage A/ASIA/Iran-05/SIS-13 in Pakistan

Author:
Syeda Sumera Naqvi; Nazish Bostan; Katsuhiko Fukai; Qurban Ali; Kazuki Morioka; Tatsuya Nishi; Muhammad Abubakar; Zaheer Ahmed; Sadia Sattar; Sundus Javed; Aamira Tariq; Asma Sadiq
Source:
Viruses 2022 v.14 no.8 pp. -
ISSN:
1999-4915
Subject:
Foot-and-mouth disease virus,   etc   ; cattle; foot-and-mouth disease; genome; livestock and meat industry; natural selection; serotypes; trees; Pakistan;     Show all 9 Subjects
Abstract:
... Foot and mouth disease (FMD) causes severe economic losses to the livestock industry of endemic countries, including Pakistan. Pakistan is part of the endemic pool 3 for foot and mouth disease viruses (FMDV), characterized by co-circulating O, A, and Asia 1 serotypes, as designated by the world reference laboratory for FMD (WRL-FMD). FMDV serotype A lineage ASIA/Iran-05 is widespread in buffalos a ...
DOI:
10.3390/v14081634

13. Preparation of a polysaccharide adjuvant and its application in the production of a foot-and-mouth disease virus-like particles vaccine

Author:
Kun Yang; Hetao Song; Xiaoni Shi; Jiaxi Ru; Shuzhen Tan; Zhidong Teng; Hu Dong; Huichen Guo; Fanhua Wei; Shiqi Sun
Source:
Biochemical engineering journal 2022 v.184 pp. 108479
ISSN:
1369-703X
Subject:
Foot-and-mouth disease virus,   etc   ; Achyranthes japonica; adjuvants; antigens; biocompatibility; emulsions; immune response; immunization; immunogenicity; livestock; oils; polysaccharides; storage time; vaccines;     Show all 14 Subjects
Abstract:
... Foot-and-mouth disease (FMD) virus-like particles (VLPs) comprise a new and effective FMD vaccine, which often requires the addition of adjuvants to induce a vigorous immune response in order to protect livestock from the challenge of FMD virus (FMDV). Oil emulsion delivery systems have been developed and used widely in the field of veterinary vaccines because of their low cost, slow release, and ...
DOI:
10.1016/j.bej.2022.108479

14. Assessment of fitness of foot‐and‐mouth disease virus A IND 27/2011 as candidate vaccine strain

Author:
Sreenivasa Beeragere Parameshwaraiah; Jajati K. Mohapatra; Veena Jumanal; Dhanesh Valia Valappil; Saravanan Subramaniam; Bhimnere Hanumanthagouda Manjunatha Patel; Suresh H. Basagoudanavar; Madhusudan Hosamani; Brahmadev Pattnaik; Raj Kumar Singh; Aniket Sanyal
Source:
Transboundary and emerging diseases 2022 v.69 no.5 pp. 2996-3000
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; amino acids; antigenic variation; capsid; cattle; cell lines; immunogenicity; inactivated vaccines; nucleotide sequences; serotypes; viruses; India;     Show all 12 Subjects
Abstract:
... Antigenic profiling of recent field outbreak strains of foot‐and‐mouth disease virus (FMDV) serotype A in India has revealed considerable antigenic drift from the vaccine strain, A IND 40/2000, necessitating the selection of a new strain. The complete genome sequence of A IND 27/2011 was analysed. Vaccine quality attributes of the new candidate strain including potency as an inactivated vaccine in ...
DOI:
10.1111/tbed.14166

15. Foot‐and‐mouth disease seroprevalence and reporting behaviours in nine northern provinces in Lao PDR: The current situation and challenges for control

Author:
Isabel MacPhillamy; James Young; Francesca Earp; Syseng Khounsy; Peter Windsor; Jenny‐Ann Toribio; Russell Bush
Source:
Transboundary and emerging diseases 2022 v.69 no.2 pp. 645-659
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; disease surveillance; foot-and-mouth disease; human population; odds ratio; risk; risk assessment; seroprevalence; villages; China; Laos;     Show all 11 Subjects
Abstract:
... Foot‐and‐mouth disease (FMD), caused by the FMD virus (FMDV), is one of the most important of global livestock diseases, impacting even‐toed ungulates and distributed mostly in less developed countries that are home to 75% of the human population. A progressive control pathway for FMD (PCP‐FMD) was developed to assist countries to better manage FMD risks and progress towards control and eradicatio ...
DOI:
10.1111/tbed.14031

16. Bio-mineralization of virus-like particles by metal–organic framework nanoparticles enhances the thermostability and immune responses of the vaccines

Author:
Zhidong Teng; Fengping Hou; Manyuan Bai; Jiajun Li; Jun Wang; Jinen Wu; Jiaxi Ru; Mei Ren; Shiqi Sun; Huichen Guo
Source:
Journal of materials chemistry B 2022 v.10 no.15 pp. 2853-2864
ISSN:
2050-7518
Subject:
Foot-and-mouth disease virus,   etc   ; biomineralization; cold chain; coordination polymers; cytokines; heat tolerance; imidazole; immunogenicity; lysosomes; nanocomposites; secretion; thermal stability; transportation; vaccines;     Show all 14 Subjects
Abstract:
... Virus-like particle (VLPs) vaccines have been extensively studied due to their good immunogenicity and safety; however, they highly rely on cold-chain storage and transportation. Nanotechnology of bio-mineralization as a useful strategy has been employed to improve the thermal stability and immunogenicity of VLPs. A zeolitic imidazole framework (ZIF-8), a core–shell structured nanocomposite, was a ...
DOI:
10.1039/d1tb02719k

17. Inferred Causal Mechanisms of Persistent FMDV Infection in Cattle from Differential Gene Expression in the Nasopharyngeal Mucosa

Author:
James J. Zhu; Carolina Stenfeldt; Elizabeth A. Bishop; Jessica A. Canter; Michael Eschbaumer; Luis L. Rodriguez; Jonathan Arzt
Source:
Pathogens 2022 v.11 no.8 pp. -
ISSN:
2076-0817
Subject:
Foot-and-mouth disease virus,   etc   ; aryl hydrocarbon receptors; cattle; chemokines; foot-and-mouth disease; gene expression regulation; interleukin-6; ligands; mucosa; neutrophils; pharynx;     Show all 11 Subjects
Abstract:
... Foot-and-mouth disease virus (FMDV) can persistently infect pharyngeal epithelia in ruminants but not in pigs. Our previous studies demonstrated that persistent FMDV infection in cattle was associated with under-expression of several chemokines that recruit immune cells. This report focuses on the analysis of differentially expressed genes (DEG) identified during the transitional phase of infectio ...
DOI:
10.3390/pathogens11080822

18. Socioeconomic impacts of clinical foot‐and‐mouth disease and a risk‐based partial vaccination campaign for smallholders in Lao People's Democratic Republic

Author:
Masako Wada; Supatsak Subharat; Ashish Sutar; Ronello Abila; Syseng Khounsy; Cord Heuer
Source:
Transboundary and emerging diseases 2022 v.69 no.5 pp. e1825
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; cattle; death; decline; foot-and-mouth disease; goats; herd size; livestock production; mortality; prices; questionnaires; swine; vaccination; villages; Laos;     Show all 15 Subjects
Abstract:
... Foot‐and‐mouth disease (FMD) is endemic in Lao People's Democratic Republic (PDR). A risk‐based partial vaccination campaign was implemented in Champasak, Savannakhet and Xiengkhouang Provinces in Lao PDR in 2016–2020, which had limited effects on reducing the circulation of FMD virus. The objectives of this study were to measure the socioeconomic effects of (i) a clinical FMD occurrence and (ii) ...
DOI:
10.1111/tbed.14517

19. An extensive analysis of Codon usage pattern, Evolutionary rate, and Phylogeographic reconstruction in Foot and mouth disease (FMD) serotypes (A, Asia 1, and O) of six major climatic zones of India: A comparative study

Author:
Mamathashree Mandya Naganayak; Suresh Kuralayanapalya Puttahonnappa; Uma Bharathi Indrabalan; Krishnamoorthy Paramanandham; Siju Susan Jacob; Saravanan Subramaniam; Sharanagouda S patil; Kumar Seethakempanahalli Kempanna; Sheshakumar Goroshi
Source:
Acta tropica 2022 v.236 pp. 106674
ISSN:
0001-706X
Subject:
Foot-and-mouth disease virus,   etc   ; codon usage; coevolution; comparative study; foot-and-mouth disease; genetic instability; livestock; phylogeography; selection pressure; serotypes; virus transmission; India;     Show all 12 Subjects
Abstract:
... Foot and mouth disease (FMD) is a major economically important viral disease of cloven-hoofed livestock globally. The FMD virus (FMDV) spreads widely in confined, cool, and humid climatic conditions. Being an RNA virus, FMDV is genetically unstable, and its genome evolution is highly influenced by mutational pressure. The climatic and environmental conditions have a significant impact on mutationa ...
DOI:
10.1016/j.actatropica.2022.106674

20. Full-Length Genomic RNA of Foot-and-Mouth Disease Virus Is Infectious for Cattle by Injection

Author:
Hanna Keck; Benedikt Litz; Bernd Hoffmann; Julia Sehl-Ewert; Martin Beer; Michael Eschbaumer
Source:
Viruses 2022 v.14 no.9 pp. -
ISSN:
1999-4915
Subject:
Foot-and-mouth disease virus,   etc   ; RNA; blood serum; cattle; diagnostic techniques; epithelium; genome; genomics; laboratory diagnosis; nose; risk; risk assessment; saliva; tongue; transfection; viruses;     Show all 16 Subjects
Abstract:
... Safe sample transport is of great importance for infectious diseases diagnostics. Various treatments and buffers are used to inactivate pathogens in diagnostic samples. At the same time, adequate sample preservation, particularly of nucleic acids, is essential to allow an accurate laboratory diagnosis. For viruses with single-stranded RNA genomes of positive polarity, such as foot-and-mouth diseas ...
DOI:
10.3390/v14091924