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1. A novel type I interferon, interferon alphaomega, shows antiviral activity against foot-and-mouth disease virus in vitro

Author:
Li, Shi-fang; Gong, Mei-jiao; Xie, Yin-li; Shao, Jun–jun; Zhao, Fu-rong; Zhang, Yong-guang; Chang, Hui-yun
Source:
Microbial pathogenesis 2019 v.127 pp. 79-84
ISSN:
0882-4010
Subject:
Foot-and-mouth disease virus,   etc   ; antiviral properties; cytopathogenicity; genes; interferons; swine; transcription (genetics);     Show all 7 Subjects
Abstract:
... Recently, a novel type I interferon alphaomega (IFN-αω), also known as IFN-μ, was identified. However, the biological activity of IFN-αω remain poorly understood. In this study, the porcine IFN-αω (PoIFN-αω) was expressed, purified, and its antiviral activities assessed by its ability to inhibit the cytopathic effect caused by FMDV on IBRS-2 cells. In addition, q-PCR was used to evaluate the expre ...
DOI:
10.1016/j.micpath.2018.11.040

2. Chimeric vaccine strain of type O foot-and-mouth disease elicits a strong immune response in pigs against ME-SA and SEA topotypes

Author:
Ko, Mi-Kyeong; Jo, Hye-Eun; Choi, Joo-Hyung; You, Su-Hwa; Shin, Sung Ho; Jo, Hyundong; Lee, Min-Ja; Kim, Su-Mi; Kim, Byounghan; Park, Jong-Hyeon
Source:
Veterinary microbiology 2019 v.229 pp. 124-129
ISSN:
0378-1135
Subject:
Foot-and-mouth disease virus,   etc   ; foot-and-mouth disease; immune response; immunogenicity; neutralizing antibodies; recombinant vaccines; swine; vaccine development; viruses;     Show all 9 Subjects
Abstract:
... Foot-and-mouth disease (FMD) is an acute infectious disease occurring in cloven-hoofed animals. There are many variations of the virus, making it difficult to protect against the various strains with one virus vaccine. The immunogenicity has generally been evaluated in pigs using neutralizing antibodies to determine the protection level against foot-and-mouth disease virus type O. Therefore, the v ...
DOI:
10.1016/j.vetmic.2018.12.023

3. Separation and purification of foot-and-mouth disease virus by multiple-stage aqueous two-phase extraction system

Author:
Du, Ping; Sun, Pu; Sun, Shiqi; Dong, Jinjie; Dong, Hu; Liu, Ronghuan; Guo, Huichen; Mu, Kebin; Liu, Zaixin
Source:
Process biochemistry 2019 v.77 pp. 143-150
ISSN:
1359-5113
Subject:
Foot-and-mouth disease virus,   etc   ; additives; centrifugation; chromatography; filtration; molecular weight; pH; polymers; sodium citrate; vaccines; virion; viruses;     Show all 12 Subjects
Abstract:
... Downstreaming vaccine production faces a challenge in adopting numerous chromatography and filtration steps to efficiently purify large viral particles. Purity, potency, and quality are the main problems that plague virus separation and purification. This article aims to evaluate a three-stage PEG-Salt aqueous two-phase extraction (ATPE) system to purify foot-and-mouth disease virus (FMDV). Unique ...
DOI:
10.1016/j.procbio.2018.11.002

4. Substitutions accrued on Foot-and-mouth disease virus capsid during propagation in cell culture

Author:
Sarangi, Laxmi N.; Mohapatra, Jajati K.; Subramaniam, Saravanan; Das, Biswajit; Sanyal, Aniket; Pattnaik, Bramhadev
Source:
Proceedings of the National Academy of Sciences, India, Section B: biological sciences 2019 v.89 no.2 pp. 747-753
ISSN:
0369-8211
Subject:
Foot-and-mouth disease virus,   etc   ; amino acid sequences; arginine; binding sites; capsid; cell culture; cell lines; genotype; heparin; histidine; receptors; sequence analysis; serotypes; viruses;     Show all 14 Subjects
Abstract:
... Three lineages of serotype O of foot-and-mouth disease virus were passaged serially in BHK-21 cell culture without application of any immune pressure, to study the frequency, nature and location of the substitutions accruing on the virus capsid. The viruses showed unusual stability as only 12 substitutions were observed in 13 different regimens and the majority of the substitutions reverted back t ...
DOI:
10.1007/s40011-018-0986-9

5. Investigating the temporal and spatial distribution of foot‐and‐mouth disease virus serotype C in the Region of South America, 1968‐2016.

Author:
Sanchez‐Vazquez, Manuel José; Buzanovsky, Lia Puppim; dos Santos, Alexandre Guerra; Allende, Rossana Maria; Cosivi, Ottorino; Rivera, Alejandro Mauricio
Source:
Transboundary and emerging diseases 2019 v.66 no.2 pp. 653-661
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; emerging diseases; foot-and-mouth disease; geographical distribution; information sources; serotypes; time series analysis; South America;     Show all 8 Subjects
Abstract:
... This study investigates the historical temporal trend and geographical distribution of the foot‐and‐mouth disease virus (FMDv) serotype C in South America; discussing the findings within the context of the actions and strategies carried out for the elimination of foot‐and‐mouth disease (FMD). This is the first time that such a comprehensive historical compilation has been carried out in the Region ...
DOI:
10.1111/tbed.13069

6. Recombination of host cell mRNA with the Asia 1 foot-and-mouth disease virus genome in cell suspension culture

Author:
Zou, Xingqi; Zhu, Yuanyuan; Bao, Huifang; Guo, Xiaoyu; Sun, Pu; Liu, Zaixin; Mason, Peter W.; Xu, Lu; Li, Cui; Zhang, Qianyi; Wang, Qin; Zhu, Hongfei; Zhao, Qizu
Source:
Archives of virology 2019 v.164 no.1 pp. 41-50
ISSN:
0304-8608
Subject:
Foot-and-mouth disease virus,   etc   ; RNA replication; cell suspension culture; evolution; genome; growth curves; heparan sulfate; inactivated vaccines; integrins; messenger RNA; mutation; phenotype; serotypes; structural proteins; transcriptome; viruses;     Show all 16 Subjects
Abstract:
... Foot-and-mouth disease virus (FMDV) exhibits high mutation rates during replication. In this study, an isolate of FMDV serotype Asia-1 was serially passaged in a BHK-21 cell monolayer and then adapted to serum-free BHK-21 cell suspension culture to produce a seed virus for production of an inactivated vaccine. Analysis of the sequence encoding the structural proteins of the virus at various passag ...
DOI:
10.1007/s00705-018-4008-2

7. Serotyping of foot-and-mouth disease virus using oxford nanopore sequencing

Author:
Hansen, Sören; Dill, Veronika; Shalaby, Mohamed A.; Eschbaumer, Michael; Böhlken-Fascher, Susanne; Hoffmann, Bernd; Czerny, Claus-Peter; Abd El Wahed, Ahmed
Source:
Journal of virological methods 2019 v.263 pp. 50-53
ISSN:
0166-0934
Subject:
Foot-and-mouth disease virus,   etc   ; RNA; animals; antigens; barcoding; cross immunity; enzyme-linked immunosorbent assay; financial economics; genome; mutants; nanopores; polymerase chain reaction; reverse transcription; serotypes; vaccination;     Show all 15 Subjects
Abstract:
... Foot-and-mouth disease virus (FMDV), belonging to the family of Picornaviridae, infects mostly cloven-hoofed animals and leads to huge economic losses. Since there is no cross-protection between the seven serotypes of FMDV, effective vaccination relies on the knowledge of the serotype causing the outbreak. The most common methods of serotyping are antigen ELISAs and amplification-based sequencing. ...
DOI:
10.1016/j.jviromet.2018.10.020

8. Expression, purification, crystallization and preliminary X-ray diffraction analysis of swine leukocyte antigen 2 complexed with a CTL epitope AS64 derived from Asia1 serotype of foot-and-mouth disease virus

Author:
Gao, Feng-shan; Feng, Lei; Jiang, Ping; Li, Zi-bin; Gao, Hua; Zhai, Xiao-xin; Zhang, Zong-hui; Hu, Xiao
Source:
BMC veterinary research 2018 v.14 no.1 pp. 407
ISSN:
1746-6148
Subject:
Foot-and-mouth disease virus,   etc   ; X-ray diffraction; crystallization; epitopes; leukocytes; major histocompatibility complex; serotypes; swine;     Show all 8 Subjects
Abstract:
... BACKGROUND: Currently, the structural characteristics of the swine major histocompatibility complex (MHC) class I molecule, also named swine leukocyte antigen class I (SLA-I) molecule need to be further clarified. RESULTS: A complex of SLA-I constituted by an SLA-2*HB01 molecule with swine β₂-microglobulin and a cytotoxic T lymphocyte (CTL) epitope FMDV-AS64 (ALLRSATYY) derived from VP1 protein (r ...
DOI:
10.1186/s12917-018-1742-3

9. Oral pre-administration of Purslane polysaccharides enhance immune responses to inactivated foot-and-mouth disease vaccine in mice

Author:
Zhao, Rui; Meng, Xiangyu; Jia, Guiyan; Yu, Yongzhong; Song, Bocui
Source:
BMC veterinary research 2019 v.15 no.1 pp. 38
ISSN:
1746-6148
Subject:
Foot-and-mouth disease virus,   etc   ; acute toxicity; animal husbandry; calcium; dose response; food additives; foot-and-mouth disease; humoral immunity; immune response; intestines; lymphocytes; mice; mucosal immunity; oral administration; polysaccharides; secretion; vaccination; vaccines;     Show all 18 Subjects
Abstract:
... BACKGROUND: Foot-and-mouth disease (FMD) is one of the greatest disease threats to animal husbandry worldwide. Though various vaccines against foot-and-mouth disease virus (FMDV) have been developed, vaccine effectiveness is still not satisfactory. In this work, we studied the potential ability of Purslane polysaccharide (POL-P3b) as a nutrient food additive to enhance immune responses to FMD vacc ...
DOI:
10.1186/s12917-019-1782-3

10. Development and validation of a competitive ELISA based on bacterium-original virus-like particles of serotype O foot-and-mouth disease virus for detecting serum antibodies

Author:
Ran, Xuhua; Yang, Zhiyuan; Bai, Manyuan; Zhang, Yun; Wen, Xiaobo; Guo, Huichen; Sun, Shiqi
Source:
Applied microbiology and biotechnology 2019 v.103 no.7 pp. 3015-3024
ISSN:
0175-7598
Subject:
Foot-and-mouth disease virus,   etc   ; animals; antibodies; antigens; biosafety; blood serum; developing countries; enzyme-linked immunosorbent assay; financial economics; foot-and-mouth disease; herd immunity; livestock and meat industry; manufacturing; serotypes; vaccination; virus-like particles;     Show all 16 Subjects
Abstract:
... Foot-and-mouth disease (FMD) is a highly contagious disease that affects all susceptible cloven-hoofed animals, resulting in considerable economic losses to animal industries worldwide. Numerous categories of enzyme-linked immunosorbent assays (ELISA) have been developed and widely used to evaluate herd immunity. Manufacturing inactivated FMD virus (FMDV) as a diagnostic antigen requires a facilit ...
DOI:
10.1007/s00253-019-09680-8

11. Foot‐and‐mouth disease outbreaks due to an exotic serotype Asia 1 virus in Myanmar in 2017

Author:
Bo, Lin Lin; Lwin, Khin Sander; Ungvanijban, Sahawatchara; Knowles, Nick J.; Wadsworth, Jemma; King, Donald P.; Abila, Ronello; Qiu, Yu
Source:
Transboundary and emerging diseases 2019 v.66 no.2 pp. 1067-1072
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; cattle; disease outbreaks; disinfection; emerging diseases; foot-and-mouth disease; genetic analysis; monitoring; quarantine; serotypes; signs and symptoms (animals and humans); trade; villages; viruses; Bangladesh; India; Myanmar;     Show all 17 Subjects
Abstract:
... In January 2017, two villages located in Rakhine State of Myanmar reported clinical signs in cattle suggestive of foot‐and‐mouth disease virus (FMDV) infection. Laboratory analysis identified the outbreak virus as FMDV serotype Asia 1, which represented the first detection of this serotype in Myanmar since 2005 and in the region of South‐East Asia (SEA) since 2007. Genetic analysis revealed that t ...
DOI:
10.1111/tbed.13112

12. Inherent biophysical stability of foot-and-mouth disease SAT1, SAT2 and SAT3 viruses

Author:
Scott, Katherine A.; Maake, Lorens; Botha, Elizabeth; Theron, Jacques; Maree, Francois F.
Source:
Virus research 2019
ISSN:
0168-1702
Subject:
Foot-and-mouth disease virus,   etc   ; RNA; buffers; capsid; climatic zones; dissociation; foot-and-mouth disease; genome; heat; mutation; pH; reverse genetics; serotypes; sodium chloride; temperature; thermal stability; vaccines; viruses; Southern Africa;     Show all 19 Subjects
Abstract:
... Foot-and-mouth disease (FMD) virus (FMDV) isolates show variation in their ability to withstand an increase in temperature. The FMDV is surprisingly thermolabile, even though this virus is probably subjected to a strong extracellular selective pressure by heat in hot climate regions where FMD is prevalent. The three SAT serotypes, with their particularly low biophysical stability also only yield v ...
DOI:
10.1016/j.virusres.2019.02.012

13. Development and Utilization of VHH Antibodies Derived from Camelus Dromedarius Against Foot-and-Mouth Disease Virus

Author:
Dash, Lipsa; Subramaniam, Saravanan; Khulape, Sagar A.; Prusty, Bikash Ranjan; Pargai, Kamal; Narnaware, Shirish D.; Patil, Niteen V.; Pattnaik, Bramhadev
Source:
Animal biotechnology 2019 v.30 no.1 pp. 57-62
ISSN:
1532-2378
Subject:
Foot-and-mouth disease virus,   etc   ; Camelus dromedarius; Escherichia coli; antibodies; antigens; coat proteins; coatings; diagnostic techniques; enzyme-linked immunosorbent assay; foot-and-mouth disease; humoral immunity; immunoglobulins; rabbits; serotypes; vaccines; wildlife;     Show all 16 Subjects
Abstract:
... Foot-and-mouth disease (FMD) is an acute, highly contagious, and economically devastating viral disease of domestic and wildlife species. For effective implementation of FMD control program, there is an imperative need for developing a rapid, sensitive, and specific diagnostics which help in the identification of serotypes involved in the outbreaks. The humoral immune response of the Camelidae is ...
DOI:
10.1080/10495398.2018.1433191

14. Purification, crystallization and preliminary X-ray crystallographic studies of swine MHC class I complexed with an FMDV CTL epitope Hu64

Author:
Feng, Lei; Sun, Ming-wei; Jiang, Ping; Li, Zi-bin; Gao, Hua; Zhai, Xiao-xin; Han, Yong; Zhang, Zong-hui; Gao, Feng-shan
Source:
Research in veterinary science 2018 v.119 pp. 205-208
ISSN:
0034-5288
Subject:
Foot-and-mouth disease virus,   etc   ; X-ray diffraction; alleles; crystal structure; crystallization; epitopes; haplotypes; leukocytes; major histocompatibility complex; serotypes; swine;     Show all 11 Subjects
Abstract:
... Up to now, no crystal structure of swine leukocyte antigen 2 (SLA-2) molecules was reported. In order to elucidate the structure of SLA-2 and to study the cytotoxic T lymphocyte (CTL) epitopes derived from foot-and-mouth disease virus (FMDV), a complex of swine major histocompatibility complex (MHC) class I molecule (SLA-2 haplotype, Hebao allele) with swine β2-microglobulin and the CTL epitope FM ...
DOI:
10.1016/j.rvsc.2018.06.018

15. Dynamics of widespread foot‐and‐mouth disease virus serotypes A, O and Asia‐1 in southern Asia: A Bayesian phylogenetic perspective

Author:
Brito, B. P.; Mohapatra, J. K.; Subramaniam, S.; Pattnaik, B.; Rodriguez, L. L.; Moore, B. R.; Perez, A. M.
Source:
Transboundary and emerging diseases 2018 v.65 no.3 pp. 696-710
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; economic impact; emerging diseases; foot-and-mouth disease; phylogeny; serotypes; trade; Afghanistan; India; Iran; Pakistan;     Show all 11 Subjects
Abstract:
... Foot‐and‐mouth disease (FMD) is, arguably, the animal disease with the most devastating global economic impact owing in part, to the severe trade restrictions imposed upon affected countries and regions. South Asia is one of the regions where widespread lineages of the FMDV virus (FMDV) have emerged. Here, we performed an integrative phylogenetic analysis of all FMDV serotypes (A, O and Asia‐1) ci ...
DOI:
10.1111/tbed.12791

16. Identification of two novel foot-and-mouth disease virus cytotoxic T lymphocyte epitopes that can bind six SLA-I proteins

Author:
Gao, Feng-Shan; Zhai, Xiao-Xin; Jiang, Ping; Zhang, Qiang; Gao, Hua; Li, Zi-Bin; Han, Yong; Yang, Jie; Zhang, Zong-hui
Source:
Gene 2018 v.653 pp. 91-101
ISSN:
0378-1119
Subject:
Foot-and-mouth disease virus,   etc   ; cytotoxic T-lymphocytes; epitopes; mass spectrometry; neutralizing antibodies; peptides; proteins; swine; vaccines;     Show all 9 Subjects
Abstract:
... Currently available vaccines from inactivated foot-and-mouth disease virus (FMDV) only protect animals by inducing neutralizing antibodies. A vaccine that contains cytotoxic T lymphocytes (CTL) epitopes to induce strong CTL responses might protect animals more effectively. Herein, we used swine leukocyte antigen class I (SLAI) proteins derived from six different strains of domestic pigs to screen ...
DOI:
10.1016/j.gene.2018.02.025

17. Immunogenic evaluation of FMD virus immuno-dominant epitopes coupled with IL-2/FcIgG in BALB/c mice

Author:
Doosti, Mohammad; Nassiri, Mohammadreza; Nasiri, Khadijeh; Tahmoorespur, Mojtaba; Zibaee, Saeed
Source:
Microbial pathogenesis 2019 v.132 pp. 30-37
ISSN:
0882-4010
Subject:
Foot-and-mouth disease virus,   etc   ; Escherichia coli; adjuvants; cell-mediated immunity; enzyme-linked immunosorbent assay; epitopes; foot-and-mouth disease; immune response; immunoglobulin G; inactivated vaccines; interferon-gamma; interleukin-10; interleukin-2; interleukin-4; mice; plasmids; recombinant vaccines; secretion; serotypes; vaccination; vaccine development; viruses; Iran;     Show all 23 Subjects
Abstract:
... Previous studies on vaccine development against foot-and-mouth disease (FMD) virus reported that application of the inactivated vaccines for FMD virus is not completely effective. Novel vaccinations based on immune-dominant epitopes showed they induced immune responses. In addition, for better and safer immunization, access to of efficient adjuvants against FMD virus seems to be critical. In this ...
DOI:
10.1016/j.micpath.2019.04.019

18. Immunogenicity and protective efficacy of recombinant proteins consisting of multiple epitopes of foot-and-mouth disease virus fused with flagellin

Author:
Cui, Baofeng; Liu, Xinsheng; Zhou, Peng; Fang, Yuzhen; Zhao, Donghong; Zhang, Yongguang; Wang, Yonglu
Source:
Applied microbiology and biotechnology 2019 v.103 no.8 pp. 3367-3379
ISSN:
0175-7598
Subject:
Foot-and-mouth disease virus,   etc   ; B-lymphocytes; T-lymphocytes; adjuvants; antibody formation; cell-mediated immunity; disease control; epitopes; flagellin; foot-and-mouth disease; guinea pigs; immunization; immunogenicity; immunoglobulin G; interferon-gamma; interleukin-12; mice; neutralization; neutralizing antibodies; oligodeoxyribonucleotides; recombinant proteins; tumor necrosis factor-alpha; vaccines;     Show all 23 Subjects
Abstract:
... Many recent studies have shown that flagellin fused to heterologous antigens can induce significantly enhanced humoral and cellular immune responses through its adjuvant activity. Therefore, in this study, two key B cell epitopes and a truncated VP1 (ΔVP1) protein from foot-and-mouth disease virus (FMDV) were expressed as flagellin fusion proteins in different patterns. Specifically, ΔVP1 and two ...
DOI:
10.1007/s00253-019-09691-5

19. Fully automated and integrated multiplex detection of high consequence livestock viral genomes on a microfluidic platform

Author:
Lung, Oliver; Fisher, Mathew; Erickson, Anthony; Nfon, Charles; Ambagala, Aruna
Source:
Transboundary and emerging diseases 2019 v.66 no.1 pp. 144-155
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; African swine fever; automation; blood serum; cost effectiveness; cross reaction; diagnostic techniques; disease control; emerging diseases; foot-and-mouth disease; genome; genotype; hog cholera; ileum; kidneys; livestock; livestock and meat industry; nose; nucleic acids; pathogens; reverse transcriptase polymerase chain reaction; serotypes; signs and symptoms (animals and humans); spleen; swine vesicular disease; tonsils; vesicular stomatitis; viruses;     Show all 28 Subjects
Abstract:
... Differential diagnosis of diseases that share common clinical signs typically requires the performance of multiple independent diagnostic tests to confirm diagnosis. Diagnostic tests that can detect and discriminate between multiple differential pathogens in a single reaction may expedite, reduce costs, and streamline the diagnostic testing workflow. Livestock haemorrhagic diseases like classical ...
DOI:
10.1111/tbed.12994

20. Characterization of naturally occurring, new and persistent subclinical foot‐and‐mouth disease virus infection in vaccinated Asian buffalo in Islamabad Capital Territory, Pakistan

Author:
Farooq, Umer; Ahmed, Zaheer; Naeem, Khalid; Bertram, Miranda; Brito, Barbara; Stenfeldt, Carolina; Pauszek, Steven J.; LaRocco, Michael; Rodriguez, Luis; Arzt, Jonathan
Source:
Transboundary and emerging diseases 2018 v.65 no.6 pp. 1836-1850
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; Bubalus bubalis; RNA; antibodies; buffaloes; carrier state; emerging diseases; endemic diseases; farms; foot-and-mouth disease; hosts; longitudinal studies; phylogeny; seroprevalence; serotypes; Pakistan;     Show all 16 Subjects
Abstract:
... The convalescent subclinical carrier state of foot‐and‐mouth disease virus (FMDV) infection has been thoroughly investigated; contrastingly, the subclinical form of new infections of vaccinated and naïve hosts is recognized, but poorly understood. To investigate the natural dynamics of subclinical FMDV infections, a prospective, 12‐month, longitudinal study was conducted in vaccinated Asian buffal ...
DOI:
10.1111/tbed.12963