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1. A novel multiple emulsion enhanced immunity via its biomimetic delivery approach

Author:
Zou, Yongjuan; Wu, Nan; Miao, Chunyu; Yue, Hua; Wu, Jie; Ma, Guanghui
Source:
Journal of materials chemistry B 2020 v.8 no.33 pp. 7365-7374
ISSN:
2050-7518
Subject:
Foot-and-mouth disease virus,   etc   ; antigen presentation; antigen-presenting cells; antigens; biomimetics; biosafety; chitosan; emulsions; endocytosis; hydrogels; nanoparticles; pathogens; vaccines;     Show all 13 Subjects
Abstract:
... To generate effective immunity post-vaccination, antigens need to be effectively captured and taken up by antigen-presenting cells (APCs) as a prerequisite. Biomimetic designs that mimic natural pathogen-like properties have provided platforms for antigen delivery. However, the structural dynamic properties of pathogens leading to their efficient internalization have been neglected in most platfor ...
DOI:
10.1039/d0tb01318h

2. Horizontal transmission of foot‐and‐mouth disease virus O/JPN/2010 among different animal species by direct contact

Author:
Fukai, Katsuhiko; Nishi, Tatsuya; Morioka, Kazuki; Yamada, Manabu; Yoshida, Kazuo; Yamakawa, Makoto
Source:
Transboundary and emerging diseases 2020 v.67 no.1 pp. 223-233
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; cows; disease transmission; emerging diseases; farms; foot-and-mouth disease; goats; swine; viral shedding;     Show all 9 Subjects
Abstract:
... Foot‐and‐mouth disease (FMD) is highly contagious and easily transmitted among species of cloven‐hoofed animals. To investigate the transmission of FMD virus (FMDV) among different animal species, experimental infections using the O/JPN/2010 strain were performed in cows, goats and pigs. One cow or two goats/pigs were housed with a different species of inoculated animals, and clinical observations ...
DOI:
10.1111/tbed.13344

3. Three‐percent sucrose acts as a thermostabilizer for cell‐adapted foot‐and‐mouth disease virus without any negative effect on viral growth

Author:
Hwang, J.‐H.; Moon, Y.; Lee, G.; Kim, M.‐Y.; Lee, K.‐N.; Park, J.‐H.; Lee, M.; Kim, B.; Kim, S.‐M.
Source:
Journal of applied microbiology 2020 v.128 no.5 pp. 1524-1531
ISSN:
1364-5072
Subject:
Foot-and-mouth disease virus,   etc   ; cell viability; freeze-thaw cycles; glycerol; mutation; pathogenicity; protective effect; sucrose; temperature; thermal stability; vaccines; viral growth; viruses;     Show all 13 Subjects
Abstract:
... AIMS: As cell‐adapted foot‐and‐mouth disease virus (FMDV) with H56R mutation in VP3 has reduced thermostability, this study aimed to investigate the effect of thermostabilizers on cell‐adapted FMDV for vaccine production. METHODS AND RESULTS: We examined the effect of 3% sucrose, 10% (or 25%) glycerol or 10% FBS on cell‐adapted FMDV O/SKR/JC/2014, containing H56R mutation in VP3, as vaccine seed v ...
DOI:
10.1111/jam.14565

4. In-situ and sensitive stability study of emulsion and aluminum adjuvanted inactivated foot-and-mouth disease virus vaccine by differential scanning fluorimetry analysis

Author:
Song, Yanmin; Yang, Yanli; Lin, Xuan; Li, Xiunan; Zhang, Xuan; Ma, Guanghui; Su, Zhiguo; Zhang, Songping
Source:
Vaccine 2020 v.38 no.14 pp. 2904-2912
ISSN:
0264-410X
Subject:
Foot-and-mouth disease virus,   etc   ; adjuvants; aluminum; aluminum hydroxide; antigens; emulsions; fluorescent dyes; fluorometry; gel chromatography; glycerol; immunogenicity; pH; quality control; screening; sucrose; vaccines; viruses;     Show all 17 Subjects
Abstract:
... Adjuvants are important to enhance the antigens immunogenicity, but may also alter the structures of antigens. Currently off-line methods for adjuvants induced antigen alteration suffer from incomplete release and possible structural alteration of antigens. Here we investigated the differential scanning fluorimetry (DSF) as an in-situ and high-throughput strategy to analyze the stability of inacti ...
DOI:
10.1016/j.vaccine.2020.02.068

5. Emergence of novel lineage of foot‐and‐mouth disease virus serotype Asia1 BD‐18 (G‐IX) in Bangladesh

Author:
Ali, M. Rahmat; Alam, A. S. M. Rubayet Ul; Amin, Md. Al; Siddique, Mohammad Anwar; Sultana, Munawar; Hossain, M. Anwar
Source:
Transboundary and emerging diseases 2020 v.67 no.2 pp. 486-493
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; Bayesian theory; emerging diseases; monitoring; mutation; mutational analysis; pathogens; phylogeny; phylogeography; sequence diversity; serotypes; vaccination; viruses; Bangladesh; India;     Show all 15 Subjects
Abstract:
... Foot‐and‐mouth disease virus (FMDV) is a highly evolutionary divergent pathogen causing great economic havoc in many countries. Among its seven existing serotypes, Asia1 is the least divergent with a single topotype both genetically and antigenically. It is reported sporadically in Indian subcontinent and was classified under lineage G‐VIII. In 2018, serotype Asia1 re‐emerged in Bangladesh after 2 ...
DOI:
10.1111/tbed.13381

6. Evidence for multiple recombination events within foot‐and‐mouth disease viruses circulating in West Eurasia

Author:
Jamal, Syed M.; Nazem Shirazi, Mohamad Hossein; Ozyoruk, Fuat; Parlak, Unal; Normann, Preben; Belsham, Graham J.
Source:
Transboundary and emerging diseases 2020 v.67 no.2 pp. 979-993
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; ancestry; emerging diseases; genome; nucleotide sequences; phylogeny; reverse transcriptase polymerase chain reaction; serotypes; structural proteins; viruses; Eurasia;     Show all 11 Subjects
Abstract:
... Phylogenetic studies on foot‐and‐mouth disease viruses (FMDVs) circulating in the West Eurasian region have largely focused on the genomic sequences encoding the structural proteins that determine the serotype. The present study has compared near‐complete genome sequences of FMDVs representative of the viruses that circulate in this region. The near‐complete genome sequences (ca. 7,600 nt) were ge ...
DOI:
10.1111/tbed.13433

7. The interference effect of maternally-derived antibodies on the serological performance of pigs immunized with a foot-and-mouth disease oil emulsion vaccine

Author:
Kim, Jaejo; Kim, Taeseong; Hong, Jang-Kwan; Lee, Hyang-Sim; Lee, Kwang-Nyeong; Jo, Hye Jun; Choi, Jieun; Choi, Jida; Lee, Seung Heon; Lee, Myoung-Heon; Kim, Byounghan; Park, Jong-Hyeon
Source:
Vaccine 2020 v.38 no.7 pp. 1723-1729
ISSN:
0264-410X
Subject:
Foot-and-mouth disease virus,   etc   ; antibodies; disease control; emulsions; field experimentation; foot-and-mouth disease; oils; sows; vaccination; vaccines; viruses; South Korea;     Show all 12 Subjects
Abstract:
... To control foot-and-mouth disease (FMD) outbreaks that originated in Jincheon County in South Korea between 2014 and 2015, several commercial vaccines were studied for their efficacy and serological performance in the field. In this study, the efficacy of the O SKR 7/10 vaccine was evaluated by challenge with the FMD virus (FMDV) O/Jincheon/SKR/2014 (O Jincheon), which has the same O/SEA/Mya-98 li ...
DOI:
10.1016/j.vaccine.2019.12.043

8. Crystallization of SLA-2*04:02:02 complexed with a CTL epitope derived from FMDV

Author:
Ning, Shuo; Wang, Zhen-Bao; Qi, Peng; Xiao, Jin; Wang, Xiao-Jia
Source:
Research in veterinary science 2020 v.128 pp. 90-98
ISSN:
0034-5288
Subject:
Foot-and-mouth disease virus,   etc   ; X-ray diffraction; crystal structure; crystallization; cytotoxic T-lymphocytes; data collection; epitopes; immunity; major histocompatibility complex; peptides; swine; vaccine development;     Show all 12 Subjects
Abstract:
... Presentation of viral epitopes by swine MHC I (termed leukocyte antigen class I, SLA I) to cytotoxic T lymphocytes (CTLs) is crucial for swine immunity. The SLA-2 structure, however, remains largely unknown. To illustrate the structural basis of swine CTL epitope presentation, the crystal structure of SLA-2*04:02:02 complexed with one peptide, derived from foot-and-mouth disease virus (FMDV), was ...
DOI:
10.1016/j.rvsc.2019.11.002

9. First detection of foot‐and‐mouth disease virus O/ME‐SA/ Ind2001e sublineage in Jordan

Author:
Ababneh, Mustafa M.; Hananeh, Wael; Bani Ismail, Zuhair; Hawawsheh, Majid; Al‐Zghoul, Mohammad; Knowles, Nick J.; van Maanen, Kees
Source:
Transboundary and emerging diseases 2020 v.67 no.1 pp. 455-460
ISSN:
1865-1674
Subject:
Foot-and-mouth disease virus,   etc   ; cattle; emerging diseases; foot-and-mouth disease; genes; goats; mortality; phylogeny; sheep; swine; viruses; Jordan; Saudi Arabia;     Show all 13 Subjects
Abstract:
... Foot‐and‐mouth disease (FMD) is a highly contagious vesicular disease that is caused by the FMD virus (FMDV). This disease affects both wild and domestic cloven‐hoofed animals, and the latter of which includes cattle, swine, sheep and goats. FMD is endemic to Jordan and has a severe impact on the productivity of domestic livestock. In January 2017, FMD outbreaks were detected in different animal s ...
DOI:
10.1111/tbed.13372

10. A novel type I interferon, interferon alphaomega, shows antiviral activity against foot-and-mouth disease virus in vitro

Author:
Li, Shi-fang; Gong, Mei-jiao; Xie, Yin-li; Shao, Jun–jun; Zhao, Fu-rong; Zhang, Yong-guang; Chang, Hui-yun
Source:
Microbial pathogenesis 2019 v.127 pp. 79-84
ISSN:
0882-4010
Subject:
Foot-and-mouth disease virus,   etc   ; antiviral properties; cytopathogenicity; genes; interferons; swine; transcription (genetics);     Show all 7 Subjects
Abstract:
... Recently, a novel type I interferon alphaomega (IFN-αω), also known as IFN-μ, was identified. However, the biological activity of IFN-αω remain poorly understood. In this study, the porcine IFN-αω (PoIFN-αω) was expressed, purified, and its antiviral activities assessed by its ability to inhibit the cytopathic effect caused by FMDV on IBRS-2 cells. In addition, q-PCR was used to evaluate the expre ...
DOI:
10.1016/j.micpath.2018.11.040

11. MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells

Author:
Ren, Tingting; Wang, Yanxue; Chen, Haotai; Wang, Kailing; Gao, Xin; Liu, Lei; Zhang, Yongguang; Sun, Yuefeng
Source:
Virus research 2020 v.286 pp. 198064
ISSN:
0168-1702
Subject:
Foot-and-mouth disease virus,   etc   ; Influenza A virus; Transmissible gastroenteritis virus; foot-and-mouth disease; gene expression regulation; genes; interferons; kidneys; microRNA; mitochondria; pathogens; swine; transcription (genetics); transfection; virus replication; viruses;     Show all 16 Subjects
Abstract:
... MicroRNAs play vital roles in regulating the battle between pathogens and host cells during viral challenging. MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. Otherwise, miR-4331-5p affects H1N1/2009 influenza A virus replication by targeting viral HA and NS. However, whether mi ...
DOI:
10.1016/j.virusres.2020.198064

12. Soluble FMDV VP1 proteins fused with calreticulin expressed in Escherichia coli under the assist of trigger factor16 (Tf16) formed into high immunogenic polymers

Author:
Liu, Chang; Feng, Hua; Liu, Yunchao; Chen, Yumei; Yang, Suzhen; Deng, Ruiguang; Zhang, Gaiping
Source:
International journal of biological macromolecules 2020 v.155 pp. 1532-1540
ISSN:
0141-8130
Subject:
Foot-and-mouth disease virus,   etc   ; Escherichia coli; calreticulin; clones; cytokines; enzyme-linked immunosorbent assay; foot-and-mouth disease; genes; guinea pigs; hydrodynamics; immunization; inactivated vaccines; light scattering; neutralizing antibodies; pathogens; polymers; secretion; subunit vaccines; viruses;     Show all 19 Subjects
Abstract:
... Foot and mouth disease virus (FMDV) is a highly contagious pathogen propagating among cloven-hoofed animals. As a major immunogenic protein, VP1 plays a pivotal role in the induction of neutralizing antibodies, which therefore is an ideal target for developing subunit vaccines. In current study, four prokaryotic expression clones (rV4C, rC4V, rV5F and rF5V) were constructed by fusing truncated cal ...
DOI:
10.1016/j.ijbiomac.2019.11.130

13. Enhanced protective immune response of foot-and-mouth disease vaccine through DNA-loaded virus-like particles

Author:
Lu, Yuanlu; Dong, Hu; Li, Jielin; Li, Luying; Wang, Miaomiao; Liu, Haiyun; Teng, Zhidong; Zhang, Yun; Jin, Ye; Guo, Huichen; Yang, Yuying; Wen, Xiaobo; Sun, Shiqi
Source:
Microbial pathogenesis 2020 v.143 pp. 104130
ISSN:
0882-4010
Subject:
Foot-and-mouth disease virus,   etc   ; deoxyribonucleases; etiological agents; foot-and-mouth disease; guinea pigs; immune response; interferon-gamma; lymphocyte proliferation; neutralizing antibodies; plasmids; recombinant vaccines; secondary immunization; vaccination; virus-like particle vaccines; virus-like particles;     Show all 15 Subjects
Abstract:
... Foot-and-mouth disease virus (FMDV) is the etiological agent of a highly contagious disease that affects cloven-hoofed animals. Virus-like particles (VLPs) can induce a robust immune response and deliver DNA and small molecules. In this study, a VLP-harboring pcDNA3.1/P12A3C plasmid was generated, and the protective immune response was characterized. Guinea pigs were injected with VLPs, naked DNA ...
DOI:
10.1016/j.micpath.2020.104130

14. Evaluating the immunogenicity of chemically-synthesised peptides derived from foot-and-mouth disease VP1, VP2 and VP3 proteins as vaccine candidates

Author:
Avendaño, Catalina; Celis-Giraldo, Carmen; Ordoñez, Diego; Díaz-Arévalo, Diana; Rodríguez-Habibe, Ibett; Oviedo, Jairo; Curtidor, Hernando; García-Castiblanco, Sebastián; Martínez-Panqueva, Fredy; Camargo-Castañeda, Andrea; Reyes, César; Bohórquez, Michel D.; Vanegas, Magnolia; Cantor, Daniela; Patarroyo, Manuel E.; Patarroyo, Manuel A.
Source:
Vaccine 2020 v.38 no.23 pp. 3942-3951
ISSN:
0264-410X
Subject:
Foot-and-mouth disease virus,   etc   ; adjuvants; antibodies; blood sampling; cattle; disease control; environmental impact; flow cytometry; fluorescent antibody technique; foot-and-mouth disease; genes; genotyping; immune response; immunization; immunogenicity; serotypes; subunit vaccines; synthetic peptides; vaccine development; viral proteins;     Show all 20 Subjects
Abstract:
... Foot-and-mouth disease (FMD) is one of the most contagious veterinary viral diseases known, having economic, social and potentially devastating environmental impacts. The vaccines currently being marketed/sold around the world for disease control and prevention in bovines do not stimulate the production of antibodies having crossed reactions to different serotypes. This means that if an animal bec ...
DOI:
10.1016/j.vaccine.2020.04.006

15. Foot-and-mouth disease virus: Prospects for using knowledge of virus biology to improve control of this continuing global threat

Author:
Belsham, Graham J.; Kristensen, Thea; Jackson, Terry
Source:
Virus research 2020 v.281 pp. 197909
ISSN:
0168-1702
Subject:
Foot-and-mouth disease virus,   etc   ; RNA; animals; antiviral agents; capsid; disease control; economic impact; genome; immunity; livestock diseases; nucleotide sequences; pathogenicity; risk; vaccines; viral proteins; virus replication; viruses; Africa; Europe; Middle East; South Asia;     Show all 21 Subjects
Abstract:
... Understanding of the biology of foot-and-mouth disease virus (FMDV) has grown considerably since the nucleotide sequence of the viral RNA was determined. The ability to manipulate the intact genome and also to express specific parts of the genome individually has enabled detailed analyses of viral components, both RNA and protein. Such studies have identified the requirements for specific function ...
DOI:
10.1016/j.virusres.2020.197909

16. Mechanism of bio-macromolecule denaturation on solid-liquid surface of ion-exchange chromatographic media – A case study for inactivated foot-and-mouth disease virus

Author:
Yang, Yanli; Song, Yanmin; Lin, Xuan; Li, Shuai; Li, Zhengjun; Zhao, Qizu; Ma, Guanghui; Zhang, Songping; Su, Zhiguo
Source:
Journal of chromatography 2020 v.1142 pp. 122051
ISSN:
1570-0232
Subject:
Foot-and-mouth disease virus,   etc   ; adsorption; case studies; denaturation; differential scanning calorimetry; dissociation; gel chromatography; ion exchange; ion exchange chromatography; pH; phase transition; sucrose; temperature; thermal stability; virus-like particles; viruses;     Show all 16 Subjects
Abstract:
... Destruction of assembly structures has been identified as a major cause for activity loss of virus and virus-like particles during their chromatographic process. A deep insight into the denaturation process at the solid-liquid interfaces is important for rational design of purification. In this study, in-situ differential scanning calorimetry (DSC) was employed to study the dissociation process of ...
DOI:
10.1016/j.jchromb.2020.122051

17. Pathogenesis, biophysical stability and phenotypic variance of SAT2 foot-and-mouth disease virus

Author:
Ramulongo, Tovhowani D.; Maree, Francois F.; Scott, Katherine; Opperman, Pamela; Mutowembwa, Paidamwoyo; Theron, Jacques
Source:
Veterinary microbiology 2020 v.243 pp. 108614
ISSN:
0378-1135
Subject:
Foot-and-mouth disease virus,   etc   ; acidification; animal diseases; cattle; cell culture; epithelium; etiological agents; foot-and-mouth disease; genome; integrins; livestock productivity; pathogenesis; pharynx; phenotypic variation; receptors; sequence diversity; signs and symptoms (animals and humans); virion; virulence;     Show all 19 Subjects
Abstract:
... Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of cloven-hoofed animals, which severely decreases livestock productivity. FMD virus (FMDV), the causative agent, initiates infection by interaction with integrin cellular receptors on pharyngeal epithelium cells, causing clinical signs one to four days after transmission to a susceptible host. However, some Southern African Ter ...
DOI:
10.1016/j.vetmic.2020.108614

18. Seroprevalence and Associated Risk Factors of Foot and Mouth Disease in Cattle in West Shewa Zone, Ethiopia

Author:
Ahmed, Beyan; Megersa, Lencho; Mulatu, Getachew; Siraj, Mohammed; Boneya, Gelma
Source:
Veterinary medicine international 2020 v.2020
ISSN:
2042-0048
Subject:
Foot-and-mouth disease virus,   etc   ; antibodies; cattle; cattle diseases; crossbreds; endemic diseases; foot-and-mouth disease; herds; odds ratio; regression analysis; risk factors; seroprevalence; serotypes; small ruminants; viral nonstructural proteins; Ethiopia;     Show all 16 Subjects
Abstract:
... Foot and mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals and one of the endemic diseases in Ethiopia. The study was aimed to estimate the seroprevalence and to assess associated risk factors of foot and mouth disease seroprevalence in West Shewa Zone. A total of 384 sera samples were collected from randomly selected cattle and tested using ELISA for antibodies aga ...
DOI:
10.1155/2020/6821809
PubMed:
32292580
PubMed Central:
PMC7150713

19. Biocompatible cationic solid lipid nanoparticles as adjuvants effectively improve humoral and T cell immune response of foot and mouth disease vaccines

Author:
Li, Shuai; Yang, Yanli; Lin, Xuan; Li, Zhengjun; Ma, Guanghui; Su, Zhiguo; Zhang, Songping
Source:
Vaccine 2020 v.38 no.11 pp. 2478-2486
ISSN:
0264-410X
Subject:
Foot-and-mouth disease virus,   etc   ; T-lymphocytes; adjuvants; antibodies; antigens; dendritic cells; electrostatic interactions; emulsions; fluorometry; foot-and-mouth disease; gel chromatography; immune response; immunoglobulin G; lipids; nanoparticles; particle size; temperature; vaccines; zeta potential;     Show all 19 Subjects
Abstract:
... In this work, we explored the potential of cationic solid lipid nanoparticles (cSLN) as efficient adjuvants for inactivated foot and mouth disease virus (iFMDV) vaccine. The cSLN were prepared by O/W emulsion method with Compritol 888 ATO as lipid matrix, and were modified by cationic lipid Didodecyldimethylammonium bromide (DDAB). The content of cationic lipid was optimized to produce cSLN with a ...
DOI:
10.1016/j.vaccine.2020.02.004

20. NLRP3 inflammasome activation by Foot-and-mouth disease virus infection mainly induced by viral RNA and non-structural protein 2B

Author:
Zhi, Xiaoying; Zhang, Yun; Sun, Shiqi; Zhang, Zhihui; Dong, Hu; Luo, Xin; Wei, Yanquan; Lu, Zengjun; Dou, Yongxi; Wu, Run; Jiang, Zhengfan; Weng, Changjiang; Seong Seo, Ho; Guo, Huichen
Source:
RNA biology 2020 v.17 no.3 pp. 335-349
ISSN:
1555-8584
Subject:
Foot-and-mouth disease virus,   etc   ; RNA; amino acids; caspase-1; cathepsin B; foot-and-mouth disease; guinea pigs; hydrophobicity; immune response; inflammasomes; interleukin-1beta; ion channels; mice; mitochondria; reactive oxygen species; secretion; vaccines; viral nonstructural proteins;     Show all 18 Subjects
Abstract:
... Foot-and-mouth disease virus (FMDV) is a positive-strand RNA virus of the family Picornaviridae. Early studies show that some viruses of Picornaviridae, such as EMCV and EV71, induce NLRP3 inflammasome activation. Our current study demonstrates that FMDV induces the secretion of caspase-1 and interleukin 1 beta (IL-1β), as well as activates the NLRP3 inflammasome in a dose- and time-dependent mann ...
DOI:
10.1080/15476286.2019.1700058
PubMed:
31840571
PubMed Central:
PMC6999635