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- Foster, Helen E., et al. Show all 7 Authors
- Cell 2017
- cryo-electron microscopy; dimerization; dynein ATPase; humans; microtubules; models; mutagenesis; proteins
- ... Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport machine capable of long-distance processive movement along microtubules. However, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin. Here, we present a cryoelectron microscopy structure of the complete 1.4-megadalton human dynein-1 complex in an inhibited state known as the phi-pa ...
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