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1. Biofilm formation of hypermucoviscous and non-hypermucoviscous Klebsiella pneumoniae recovered from clinically affected African green monkey (Chlorocebus aethiops sabaeus)

Author:
Francis, Stewart,   et al.   ; Soto, Esteban; Dennis, Michelle M.; Beierschmitt, Amy; Sithole, Fortune; Halliday-Simmons, Iona; Palmour, Roberta;     Show all 7 Authors
Source:
Microbial pathogenesis 2017 v.107 pp. 198-201
ISSN:
0882-4010
Subject:
Cercopithecus aethiops; Klebsiella pneumoniae; abscess; biofilm; genes; pathogenicity; pathogens; phenotype; serotypes; temperature; wildlife
Abstract:
... In recent years, an emergent Klebsiella pneumoniae hypermucoviscous (HMV) phenotype has been associated with increased invasiveness and pathogenicity in primates. The HMV phenotype is characterized by different capsular serotypes, associated with several genes including the rmpA (regulator of mucoid phenotype) and magA (mucoviscosity-associated) genes. In African green monkeys (AGM) (Chlorocebus a ...
DOI:
10.1016/j.micpath.2017.03.034

2. Interaction of non-human primate complement and antibodies with hypermucoviscous Klebsiella pneumoniae

Author:
Francis, Stewart,   et al.   ; Soto, Esteban; Marchi, Sylvia; Beierschmitt, Amy; Kearney, Michael; VanNess, Kimberly; Vandenplas, Michel; Thrall, MaryAnna; Palmour, Roberta;     Show all 9 Authors
Source:
Veterinary research 2016 v.47 no.1 pp. 40
ISSN:
1297-9716
Subject:
Cercopithecus aethiops; Klebsiella pneumoniae; animal models; antibodies; blood serum; complement; flow cytometry; humans; immune response; immunoglobulin G; leukocytes; pathogenesis; pathogenicity; phenotype; seroprevalence; vaccine development; viability
Abstract:
... Emergent hypermucoviscosity (HMV) phenotypes of Klebsiella pneumoniae have been associated with increased invasiveness and pathogenicity in primates. In this study, we investigated the interaction of African green monkeys (AGM) (Chlorocebus aethiops sabaeus) complement and antibody with HMV and non-HMV isolates as in vitro models of primate infection. Significantly greater survival of HMV isolates ...
DOI:
10.1186/s13567-016-0325-1
PubMed:
26951091
PubMed Central:
PMC4782414

3. Improved Broth Microdilution Method for Antimicrobial Susceptibility Testing of Francisella Noatunensis Orientalis

Author:
Francis, Stewart,   et al.   ; Soto, Esteban; Halliday-Simmonds, Iona; Fraites, Trellor; Martínez-López, Beatriz; Wiles, Judy; Hawke, John P.; Endris, Richard D.;     Show all 8 Authors
Source:
Journal of Aquatic Animal Health 2016 v.28 no.3 pp. 199-207
ISSN:
1548-8667
Subject:
Escherichia coli; Francisella; ampicillin; antibiotic resistance; enrofloxacin; erythromycin; fish; florfenicol; flumequine; gentamicin; glucose; minimum inhibitory concentration; monitoring; oxolinic acid; oxytetracycline; pH; quality control; sulfonamides; therapeutics
Abstract:
... In this project we optimized a minimal inhibitory concentration testing protocol for Francisella noatunensis orientalis . Thirty-three F. noatunensis orientalis isolates recovered from different fish species and locations were tested, and Escherichia c o li ATCC 25922 was used as a quality control reference strain. A modified cation-adjusted Mueller Hinton broth supplemented with 2% IsoVitalex and ...
DOI:
10.1080/08997659.2016.1185051

4. Biofilm formation of Francisella noatunensis subsp. orientalis

Author:
Francis, Stewart,   et al.   ; Soto, Esteban; Halliday-Simmonds, Iona; Kearney, Michael T.; Hansen, John D.;     Show all 5 Authors
Source:
Veterinary microbiology 2015 v.181 no.3-4 pp. 313-317
ISSN:
0378-1135
Subject:
Francisella; aquaculture; aquariums; bacteria; biofilm; bleaching agents; disinfectants; environmental factors; fish industry; freshwater; hydrogen peroxide; loci; minimum inhibitory concentration; mutation; ornamental fish; pathogens; plankton; salinity; temperature; virulence
Abstract:
... Francisella noatunensis subsp. orientalis (Fno) is an emergent fish pathogen in both marine and fresh water environments. The bacterium is suspected to persist in the environment even without the presence of a suitable fish host. In the present study, the influence of different abiotic factors such as salinity and temperature were used to study the biofilm formation of different isolates of Fno in ...
DOI:
10.1016/j.vetmic.2015.10.007

5. Distribution, abundance and demography of green pythons (Morelia viridis) in Cape York Peninsula, Australia

Author:
Natusch, David Francis Stewart,   et al.   ; Natusch, Daniel James Deans;     Show all 2 Author
Source:
Australian journal of zoology 2011 v.59 no.3 pp. 145-155
ISSN:
0004-959X
Subject:
Python; adults; demographic statistics; habitats; rain forests; rivers; shrublands; snakes; surveys; trade; vines; watersheds; Australia
Abstract:
... The green python (Morelia viridis) is an iconic snake species highly sought after in the pet trade and is the target of illegal collection. Despite their popularity, some important ecological attributes of green pythons remain unknown, making their effective conservation management difficult. Detection-only surveys were conducted throughout the potential range of the green python in Australia, and ...
DOI:
10.1071/ZO11031

6. Effect of size and temperature at vaccination on immunization and protection conferred by a live attenuated Francisella noatunensis immersion vaccine in red hybrid tilapia

Author:
Francis, Stewart,   et al.   ; Soto, Esteban; Brown, Nicholas; Gardenfors, Zackarias O.; Yount, Shaun; Revan, Floyd; Kearney, Michael T.; Camus, Alvin;     Show all 8 Authors
Source:
Fish & shellfish immunology 2014 v.41 no.2 pp. 593-599
ISSN:
1050-4648
Subject:
Francisella; antibodies; blood serum; death; disease control; farmed fish; fingerlings; freshwater fish; genome; hybrids; loci; mortality; mucus; mutants; pathogens; spleen; temperature; vaccination; vaccines; virulent strains
Abstract:
... Francisella noatunensis subsp. orientalis (Fno) is a pleomorphic, facultative intracellular, Gram-negative, emerging bacterial pathogen of marine and fresh water fish with worldwide distribution. In this study, the efficacy of an attenuated Fno intracellular growth locus C (iglC) mutant was evaluated for use as a live immersion vaccine, when administered to hybrid tilapia at two different stages o ...
DOI:
10.1016/j.fsi.2014.10.009

7. The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

Author:
Francis Stewart, A.,   et al.   ; Marks, Hendrik; Kalkan, Tüzer; Menafra, Roberta; Denissov, Sergey; Jones, Kenneth; Hofemeister, Helmut; Nichols, Jennifer; Kranz, Andrea; Smith, Austin; Stunnenberg, Hendrik G.;     Show all 11 Authors
Source:
Cell 2012 v.149 no.3 pp. 590-604
ISSN:
0092-8674
Subject:
DNA-directed RNA polymerase; blood serum; chromatin; cultured cells; gene expression regulation; genes; histones; mice; transcription (genetics); transcriptome
Abstract:
... Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as “2i” postulated to establish a naive ground state. We show that the transcriptome and epigenome profiles of serum- and 2i-grown ES cells are distinct. 2i-treated ...
DOI:
10.1016/j.cell.2012.03.026
PubMed:
22541430
PubMed Central:
PMC3398752

8. The mammalian gene function resource: the international knockout mouse consortium

Author:
Francis Stewart, A.,   et al.   ; Bradley, Allan; Anastassiadis, Konstantinos; Ayadi, Abdelkader; Battey, James F.; Bell, Cindy; Birling, Marie-Christine; Bottomley, Joanna; Brown, Steve D.; Bürger, Antje; Bult, Carol J.; Bushell, Wendy; Collins, Francis S.; Desaintes, Christian; Doe, Brendan; Economides, Aris; Eppig, Janan T.; Finnell, Richard H.; Fletcher, Colin; Fray, Martin; Frendewey, David; Friedel, Roland H.; Grosveld, Frank G.; Hansen, Jens; Hérault, Yann; Hicks, Geoffrey; Hörlein, Andreas; Houghton, Richard; Hrabé de Angelis, Martin; Huylebroeck, Danny; Iyer, Vivek; de Jong, Pieter J.; Kadin, James A.; Kaloff, Cornelia; Kennedy, Karen; Koutsourakis, Manousos; Kent Lloyd, K. C.; Marschall, Susan; Mason, Jeremy; McKerlie, Colin; McLeod, Michael P.; von Melchner, Harald; Moore, Mark; Mujica, Alejandro O.; Nagy, Andras; Nefedov, Mikhail; Nutter, Lauryl M.; Pavlovic, Guillaume; Peterson, Jane L.; Pollock, Jonathan; Ramirez-Solis, Ramiro; Rancourt, Derrick E.; Raspa, Marcello; Remacle, Jacques E.; Ringwald, Martin; Rosen, Barry; Rosenthal, Nadia; Rossant, Janet; Ruiz Noppinger, Patricia; Ryder, Ed; Schick, Joel Zupicich; Schnütgen, Frank; Schofield, Paul; Seisenberger, Claudia; Selloum, Mohammed; Simpson, Elizabeth M.; Skarnes, William C.; Smedley, Damian; Stanford, William L.; Stone, Kevin; Swan, Kate; Tadepally, Hamsa; Teboul, Lydia; Tocchini-Valentini, Glauco P.; Valenzuela, David; West, Anthony P.; Yamamura, Ken-ichi; Yoshinaga, Yuko; Wurst, Wolfgang;     Show all 79 Authors
Source:
Mammalian genome 2012 v.23 no.9-10 pp. 580-586
ISSN:
0938-8990
Subject:
Internet; biomedical research; clones; gene targeting; genes; mice; mutants; mutation; trapping
Abstract:
... In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell cl ...
DOI:
10.1007/s00335-012-9422-2
PubMed:
22968824
PubMed Central:
PMC3463800