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- Franken, Angelique C. W., et al. Show all 8 Authors
- Applied microbiology and biotechnology 2013 v.97 no.22 pp. 9773-9785
- Aspergillus niger; Saccharomyces cerevisiae; aminolevulinic acid; biosynthesis; color; cytochrome P-450; enzyme activity; gene deletion; gene overexpression; genes; heme; hemoglobin; high performance liquid chromatography; hosts; hyphae; mutants; peroxidase; phenotype
- ... Heme is a suggested limiting factor in peroxidase production by Aspergillus spp., which are well-known suitable hosts for heterologous protein production. In this study, the role of genes coding for coproporphyrinogen III oxidase (hemF) and ferrochelatase (hemH) was analyzed by means of deletion and overexpression to obtain more insight in fungal heme biosynthesis and regulation. These enzymes rep ...
- Franken, Angelique C. W., et al. Show all 6 Authors
- Applied microbiology and biotechnology 2011 v.91 no.3 pp. 447-460
- Aspergillus niger; biochemical pathways; biosynthesis; chemical industry; fungi; heme; host strains; hosts; hydrophobicity; iron; oxygen; peroxidase; prices; protein secretion; proteins
- ... Heme biosynthesis in fungal host strains has acquired considerable interest in relation to the production of secreted heme-containing peroxidases. Class II peroxidase enzymes have been suggested as eco-friendly replacements of polluting chemical processes in industry. These peroxidases are naturally produced in small amounts by basidiomycetes. Filamentous fungi like Aspergillus sp. are considered ...
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