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- Gallego, Oriol, et al. Show all 9 Authors
- Cell 2017 v.168 no.3 pp. 400-412.e18
- direct contact; exocytosis; fluorescence microscopy; plasma membrane; secretory granules; yeasts
- ... The structural characterization of protein complexes in their native environment is challenging but crucial for understanding the mechanisms that mediate cellular processes. We developed an integrative approach to reconstruct the 3D architecture of protein complexes in vivo. We applied this approach to the exocyst, a hetero-octameric complex of unknown structure that is thought to tether secretory ...
- Gallego, Oriol, et al. Show all 10 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.52 pp. 20764-20769
- aldehyde reductase; cell proliferation; crystal structure; cyclohexenes; diabetes; humans; isomers; models; molecular dynamics; neoplasms; retinaldehyde; retinoic acid; site-directed mutagenesis
- ... AKR1B10 is a human aldo-keto reductase (AKR) found to be elevated in several cancer types and in precancerous lesions. In vitro, AKR1B10 exhibits a much higher retinaldehyde reductase activity than any other human AKR, including AKR1B1 (aldose reductase). We here demonstrate that AKR1B10 also acts as a retinaldehyde reductase in vivo. This activity may be relevant in controlling the first step of ...
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