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You searched for: Subject "Gallid alphaherpesvirus 2" Remove constraint Subject: "Gallid alphaherpesvirus 2"
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1. Deletion of miR-M8 and miR-M13 eliminates the bursa atrophy induced by Marek’s disease virus infection

Author:
Yilin Bai; Yifei Liao; Shuaikang Yang; Jiaxin Jin; Wenlong Lu; Man Teng; Jun Luo; Gaiping Zhang; Aijun Sun; Guoqing Zhuang
Source:
Veterinary microbiology 2022 v.268 pp. 109409
ISSN:
0378-1135
Subject:
Gallid alphaherpesvirus 2,   etc   ; animal experimentation; atrophy; genome; microRNA; microbiology; pathogenesis;     Show all 7 Subjects
Abstract:
... Marek’s disease (MD) is a neoplastic disease of chickens caused by an avian alphaherpesvirus, Marek’s disease virus (MDV, also known as Gallid alphaherpesvirus 2 [GaHV2]). A total of 14 microRNA (miRNA) precursors and 26 mature miRNAs have been identified in MDV genome, which were grouped in three distinct clusters. In recent years, our studies revealed the role of MDV encoded cluster 3 miRNAs (or ...
DOI:
10.1016/j.vetmic.2022.109409

2. Quantitative profiling of Marek’s Disease Virus in vaccinated layer chicken

Author:
K. Senthil Kumar; Suresh P.; Sukumar K.; Saravanan S.; Raja A.; Thangavelu A.
Source:
Veterinary microbiology 2022 v.264 pp. 109305
ISSN:
0378-1135
Subject:
Gallid alphaherpesvirus 2,   etc   ; Gallid alphaherpesvirus 3; blood; disease outbreaks; feathers; hatcheries; laying hens; microbiology; quantitative polymerase chain reaction; serotypes; vaccination; vaccines; viral load; India;     Show all 14 Subjects
Abstract:
... The present study was undertaken to quantify the Marek’s Disease Virus (MDV) serotypes in vaccinated commercial layer flocks at 7, 14, 21, 28, 35 and 60-90 days post vaccination (dpv) and to correlate the pathogenic Gallid herpesvirus 2 (GaHV-2, MDV1) load with vaccine viral load of Gallid herpesvirus 3 (GaHV-3, MDV2) and Meleagridis herpesvirus 1 (MeHV-1, MDV3). A total of 25 commercial layer flo ...
DOI:
10.1016/j.vetmic.2021.109305

3. A Review on the Marek’s Disease Outbreak and Its Virulence-Related meq Genovariation in Asia between 2011 and 2021

Author:
Baolin Song; Jehan Zeb; Sabir Hussain; Muhammad Umair Aziz; Elena Circella; Gaia Casalino; Antonio Camarda; Guan Yang; Nicolas Buchon; Olivier Sparagano
Source:
Animals 2022 v.12 no.5 pp. -
ISSN:
2076-2615
Subject:
Gallid alphaherpesvirus 2,   etc   ; Japan; amino acids; disease outbreaks; genes; gizzard; heart; intestines; kidneys; liver; lungs; lymphoma; mortality; nerve tissue; phylogeny; poultry; spleen; vaccines; virulence; China; India; Indonesia; Iran; Iraq; Middle East; Saudi Arabia;     Show all 26 Subjects
Abstract:
... Marek’s disease is an infectious disease in poultry that usually appears in neural and visceral tumors. This disease is caused by Gallid alphaherpesvirus 2 infection in lymphocytes, and its meq gene is commonly used in virulent studies for coding the key protein functional in oncogenic transformation of the lymphocytes. Although vaccines have been introduced in many countries to control its spread ...
DOI:
10.3390/ani12050540

4. Deletion of the Viral Thymidine Kinase in a Meq-Deleted Recombinant Marek’s Disease Virus Reduces Lymphoid Atrophy but Is Less Protective

Author:
Steven J. Conrad; Eniope B. Oluwayinka; Mohammad Heidari; Jody K. Mays; John R. Dunn
Source:
Microorganisms 2021 v.10 no.1 pp. -
ISSN:
2076-2607
Subject:
Gallid alphaherpesvirus 2,   etc   ; atrophy; etiological agents; immunosuppression; live vaccines; oncogenes; serotypes; thymidine kinase; vaccination; viruses;     Show all 10 Subjects
Abstract:
... Marek’s disease (MD) is a ubiquitous disease of domesticated chickens and its etiologic agent is the Gallid alphaherpesvirus 2 (GaHV-2), also known as Marek’s disease virus (MDV). MD is currently controlled by vaccination using live attenuated strains of MDV (e.g., CVI988/Rispens), non-pathogenic serotypes of MDV (GaHV-3), or non-pathogenic strains of the related Melagrid alphaherpesvirus 1 (MeHV- ...
DOI:
10.3390/microorganisms10010007

5. The Requirement of Glycoprotein C for Interindividual Spread Is Functionally Conserved within the Alphaherpesvirus Genus (Mardivirus), but Not the Host (Gallid)

Author:
Widaliz Vega-Rodriguez; Nagendraprabhu Ponnuraj; Maricarmen Garcia; Keith W. Jarosinski
Source:
Viruses 2021 v.13 no.8 pp. -
ISSN:
1999-4915
Subject:
Gallid alphaherpesvirus 2,   etc   ; Gallid alphaherpesvirus 1; Meleagrid alphaherpesvirus 1; chickens; complement; glycoproteins; host specificity; viruses;     Show all 8 Subjects
Abstract:
... Marek’s disease (MD) in chickens is caused by Gallid alphaherpesvirus 2, better known as MD herpesvirus (MDV). Current vaccines do not block interindividual spread from chicken-to-chicken, therefore, understanding MDV interindividual spread provides important information for the development of potential therapies to protect against MD, while also providing a natural host to study herpesvirus disse ...
DOI:
10.3390/v13081419

6. First report of Serotype-1 Marek’s disease virus (MDV-1) with oncogenic form in backyard turkeys in Turkey: a molecular analysis study

Author:
Hasan Ongor; Necati Timurkaan; Hasan Abayli; Burak Karabulut; Hakan Kalender; Sukru Tonbak; Hatice Eroksuz; Burhan Çetinkaya
Source:
BMC veterinary research 2022 v.18 no.1 pp. 30
ISSN:
1746-6148
Subject:
Gallid alphaherpesvirus 2,   etc   ; amino acids; computer software; flocks; genes; lymphoma; nucleotide sequences; pathotypes; phylogeny; sequence analysis; statistical analysis; veterinary medicine; virulence; viruses;     Show all 14 Subjects
Abstract:
... BACKGROUND: Marek’s disease (MD) is a lymphoproliferative disease caused by Gallid alphaherpesvirus 2 (GaHV-2, MDV-1), which primarily affects chickens. However, the virus is also able to induce tumors and polyneuritis in turkeys, albeit less frequently than in chickens. RESULTS: This is the first study in Turkey reporting the molecular characterization of a MDV-1 strain detected in a flock of bac ...
DOI:
10.1186/s12917-021-03130-2

7. US3 Serine/Threonine Protein Kinase from MDV-1, MDV-2, and HVT Differentially Regulate Viral Gene Expression and Replication

Author:
Yifei Liao; Xin Fang; Mohammad AI-Mahmood; Qinglei Li; Blanca Lupiani; Sanjay M. Reddy
Source:
Microorganisms 2021 v.9 no.4 pp. -
ISSN:
2076-2607
Subject:
Gallid alphaherpesvirus 2,   etc   ; Meleagrid alphaherpesvirus 1; birds; cell culture; fluorescent antibody technique; gene expression; immunohistochemistry; pathogenesis; serine; spleen; threonine; virus replication; viruses;     Show all 13 Subjects
Abstract:
... Gallid alphaherpesvirus 2 (GaHV-2), commonly known as Marek’s disease virus type 1 (MDV-1), is an oncogenic avian alphaherpesvirus, and along with its close relatives—Gallid alphaherpesvirus 3 (GaHV-3) or MDV-2 and Meleagrid alphaherpesvirus 1 (MeHV-1) or turkey herpesvirus (HVT)—belongs to the Mardivirus genus. We and others previously showed that MDV-1 US3 protein kinase plays an important role ...
DOI:
10.3390/microorganisms9040785

8. Molecular characterization of a Marek’s disease virus strain detected in tumour-bearing turkeys

Author:
Giulia Mescolini; Caterina Lupini; Irit Davidson; Paola Massi; Giovanni Tosi; Laura Fiorentini; Elena Catelli
Source:
Avian pathology 2020 v.49 no.2 pp. 202-207
ISSN:
1465-3338
Subject:
Gallid alphaherpesvirus 2,   etc   ; flocks; genes; genetic similarity; lymphoma; phylogeny; vaccination; virulence; viruses;     Show all 9 Subjects
Abstract:
... Marek’s disease (MD) is a lymphoproliferative disease caused by Gallid alphaherpesvirus 2 (GaHV-2), which primarily affects chickens. However, the virus is also able to induce tumours in turkeys, albeit less frequently than in chickens. This study reports the molecular characterization of a GaHV-2 strain detected in a flock of Italian meat-type turkeys exhibiting visceral lymphomas. Sequencing and ...
DOI:
10.1080/03079457.2019.1691715

9. Codon Deoptimization of UL54 in meq-Deleted Marek's Disease Vaccine Candidate Eliminates Lymphoid Atrophy but Reduces Vaccinal Protection

Author:
Steven J. Conrad; Cari J. Hearn; Robert F. Silva; John R. Dunn
Source:
Avian diseases 2020 v.64 no.3 pp. 243-246
ISSN:
0005-2086
Subject:
Gallid alphaherpesvirus 2,   etc   ; Marek disease; atrophy; economic impact; etiological agents; genes; mutants; poultry industry; vaccines; viral genome; viruses;     Show all 11 Subjects
Abstract:
... Marek's disease (MD) is an oncogenic, lymphoproliferative, and highly contagious disease of chickens. Its etiologic agent is the alphaherpesvirus Marek's disease virus (MDV, Gallid alphaherpesvirus 2), and it is a chronic and ubiquitous problem for the poultry industry with significant economic impact in the United States and worldwide. We have previously demonstrated that MDV attenuated by dicodo ...
DOI:
10.1637/aviandiseases-D-19-00166

10. Marek’s Disease Virus Cluster 3 miRNAs Restrict Virus’ Early Cytolytic Replication and Pathogenesis

Author:
Yifei Liao; Guoqing Zhuang; Aijun Sun; Owais A. Khan; Blanca Lupiani; Sanjay M. Reddy
Source:
Viruses 2020 v.12 no.11 pp. -
ISSN:
1999-4915
Subject:
Gallid alphaherpesvirus 2,   etc   ; animal models; atrophy; cell culture; chickens; death; genome; lymphatic system; lymphocytes; microRNA; neoplasms; pathogenesis; phenotype; virus replication; viruses;     Show all 15 Subjects
Abstract:
... Herpesvirus-encoded microRNAs (miRNAs) have been discovered in infected cells; however, lack of a suitable animal model has hampered functional analyses of viral miRNAs in vivo. Marek’s disease virus (MDV) (Gallid alphaherpesvirus 2, GaHV-2) genome contains 14 miRNA precursors, which encode 26 mature miRNAs, grouped into three clusters. In this study, the role of MDV-encoded cluster 3 miRNAs, also ...
DOI:
10.3390/v12111317

11. The requirement of glycoprotein C (gC) for interindividual spread is a conserved function of gC for avian herpesviruses

Author:
Vega-Rodriguez Widaliz; Xu Huai; Ponnuraj Nagendraprabhu; Akbar Haji; Kim Taejoong; Jarosinski Keith William
Source:
Scientific reports 2021 v.11 no.1 pp. 7753
ISSN:
2045-2322
Subject:
Gallid alphaherpesvirus 2,   etc   ; Gallid alphaherpesvirus 3; Marek disease; cell culture; fluorescence microscopy; fluorescent proteins; genome; glycoproteins; poultry industry; vaccines; virus replication; viruses;     Show all 12 Subjects
Abstract:
... We have formerly shown that glycoprotein C (gC) of Gallid alphaherpesvirus 2, better known as Marek's disease (MD) alphaherpesvirus (MDV), is required for interindividual spread in chickens. Since gC is conserved within the Alphaherpesvirinae subfamily, we hypothesized gC was important for interindividual spread of other alphaherpesviruses. To test this hypothesis, we first generated a fluorescent ...
Handle:
10113/7709523
DOI:
10.1038/s41598-021-87400-x

12. Marek’s disease virus in vaccinated poultry flocks in Turkey: its first isolation with molecular characterization

Author:
Emre Ozan; Bahadir Muftuoglu; Ismail Sahindokuyucu; Hanne Nur Kurucay; Sinem Inal; Nilufer Kuruca; Ahmed Eisa Elhag; Efe Karaca; Cuneyt Tamer; Semra Gumusova; Harun Albayrak; Gerald Barry; Mustafa Yavuz Gulbahar; Zafer Yazici
Source:
Archives of virology 2021 v.166 no.2 pp. 559-569
ISSN:
0304-8608
Subject:
Gallid alphaherpesvirus 2,   etc   ; Marek disease; cell culture; death; genes; necropsy; nucleotide sequences; poultry industry; sequence analysis; spleen; vaccination; virology; virulence; virulent strains; viruses;     Show all 15 Subjects
Abstract:
... Marek's disease (MD) is an important disease of avian species and a potential threat to the poultry industry worldwide. In this study, 16 dead commercial chickens from flocks with suspected MD were necropsied immediately after death. Pathological findings were compatible with MD, and gallid alphaherpesvirus 2 was identified in PCR of spleen samples. Virus isolation was performed in primary cell cu ...
DOI:
10.1007/s00705-020-04943-6

13. Epigenetic Silencing of MicroRNA-126 Promotes Cell Growth in Marek’s Disease

Author:
Isabelle Gennart; Astrid Petit; Laetitia Wiggers; Srđan Pejaković; Nicolas Dauchot; Sylvie Laurent; Damien Coupeau; Benoît Muylkens
Source:
Microorganisms 2021 v.9 no.6 pp. -
ISSN:
2076-2607
Subject:
Gallid alphaherpesvirus 2,   etc   ; DNA methylation; Herpesviridae infections; cell growth; cell proliferation; chickens; epidermal growth factor; epigenetics; genes; genomic islands; humans; lymphoma; microRNA; viral genome;     Show all 14 Subjects
Abstract:
... During latency, herpesvirus infection results in the establishment of a dormant state in which a restricted set of viral genes are expressed. Together with alterations of the viral genome, several host genes undergo epigenetic silencing during latency. These epigenetic dysregulations of cellular genes might be involved in the development of cancer. In this context, Gallid alphaherpesvirus 2 (GaHV- ...
DOI:
10.3390/microorganisms9061339

14. Marek's disease viruses circulating in commercial poultry in Italy in the years 2015–2018 are closely related by their meq gene phylogeny

Author:
Giulia Mescolini; Caterina Lupini; Irit Davidson; Paola Massi; Giovanni Tosi; Elena Catelli
Source:
Transboundary and emerging diseases 2020 v.67 no.1 pp. 98-107
ISSN:
1865-1674
Subject:
Gallid alphaherpesvirus 2,   etc   ; Marek disease; chickens; emerging diseases; financial economics; flocks; genes; lymphoma; nucleotide sequences; phylogeny; poultry industry; prediction; proline; sequence analysis; statistical analysis; transcriptional activation; vaccination; virulence; Italy;     Show all 19 Subjects
Abstract:
... Marek's disease (MD) is a lymphoproliferative disease important to the poultry industry worldwide; it is caused by Gallid alphaherpesvirus 2 (GaHV‐2). The virulence of GaHV‐2 isolates has shifted over the years from mild to virulent, very virulent and very virulent +. Nowadays the disease is controlled by vaccination, but field strains of increased virulence are emerging worldwide. Economic losses ...
DOI:
10.1111/tbed.13327

15. Efficient Mutagenesis of Marek’s Disease Virus-Encoded microRNAs Using a CRISPR/Cas9-Based Gene Editing System

Author:
Jun Luo; Man Teng; Xusheng Zai; Na Tang; Yaoyao Zhang; Ahmedali Mandviwala; Vishwanatha R. A. P. Reddy; Susan Baigent; Yongxiu Yao; Venugopal Nair
Source:
Viruses 2020 v.12 no.4 pp. -
ISSN:
1999-4915
Subject:
Gallid alphaherpesvirus 2,   etc   ; CRISPR-Cas systems; Marek disease; T-cell lymphoma; bacterial artificial chromosomes; carcinogenesis; chickens; gene editing; genes; growth models; homologous recombination; microRNA; mutagenesis; mutants; transfection; viral growth; virus replication; viruses;     Show all 18 Subjects
Abstract:
... The virus-encoded microRNAs (miRNAs) have been demonstrated to have important regulatory roles in herpesvirus biology, including virus replication, latency, pathogenesis and/or tumorigenesis. As an emerging efficient tool for gene editing, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system has been successfully applied in manipulating the genomes of large DNA viruses ...
DOI:
10.3390/v12040466

16. Two Cases of Marek's Disease in Backyard Turkeys

Author:
Rüdiger Hauck; Jody Mays; John R. Dunn; H. L. Shivaprasad
Source:
Avian diseases 2020 v.64 no.3 pp. 347-351
ISSN:
0005-2086
Subject:
Gallid alphaherpesvirus 2,   etc   ; Marek disease; Reticuloendotheliosis virus; flocks; histopathology; immunohistochemistry; liver; lymphatic diseases; necropsy; spleen; toms; turkey hens; viruses; zoos;     Show all 14 Subjects
Abstract:
... In two independent submissions, a 3-yr-old, dead Bourbon Red turkey tom from a zoo and a Royal Palm turkey hen from a backyard flock were submitted for necropsy. Both birds had been kept together with chickens. Findings of the necropsy of the first turkey were an enlarged and dark liver with many pale white foci and a few small white nodules, pale and enlarged spleen, prominent thymus, mottled and ...
DOI:
10.1637/aviandiseases-D-19-00177

17. A high frequency of Gallid herpesvirus-2 co-infection with Reticuloendotheliosis virus is associated with high tumor rates in Chinese chicken farms

Author:
Yanping Zhang; Zhenghao Yu; Xingge Lan; Feng Zhang; Qi Wang; Kai Li; Qing Pan; Yulong Gao; Xiaole Qi; Hong-yu Cui; Yongqiang Wang; Li Gao; Xiaomei Wang; Changjun Liu
Source:
Veterinary microbiology 2019 pp. -
ISSN:
0378-1135
Subject:
Gallid alphaherpesvirus 2,   etc   ; Marek disease; Reticuloendotheliosis virus; chickens; farms; flocks; mixed infection; monitoring; morbidity; mortality; neoplasms; pathogenicity; poultry industry; vaccination; vaccines; China;     Show all 16 Subjects
Abstract:
... The prevalence of Marek’s disease (MD) caused by Gallid herpesvirus-2 (GaHV-2) has been increasing in chickens in China despite universal vaccination. Among the possible reasons for this trend, of Reticuloendotheliosis virus (REV) contamination in vaccines could lead to co-infection and reduce the vaccine efficacy. Here, we report the epidemiological findings of our continuous surveillance of MD, ...
DOI:
10.1016/j.vetmic.2019.108418

18. Comparative study on biological material for molecular diagnosis of Gallid herpesvirus 2

Author:
Venkataramireddy Balena; M.R. Reddy; Rajendra Singh
Source:
Indian journal of animal research 2019 v.53 no.3 pp. 404-407
ISSN:
0976-0555
Subject:
Gallid alphaherpesvirus 2,   etc   ; Marek disease; animal research; comparative study; feathers; genes; necropsy; neoplasms; nerve tissue; probability; spleen;     Show all 11 Subjects
Abstract:
... The present study was intended to investigate the sensitivity of different tissues of tumorous and non-tumorous birds to the polymerize chain reaction-baseddiagnosis of Marek's disease. Tissue samples were collected from spleen, sciatic nerve, feather follicles and tumour parts (if any)of chickens during the routine necropsy examination. The presence of Marek's disease virus was examined using pri ...
DOI:
10.18805/ijar. B-3499

19. Molecular characterization of the meq gene of Marek's disease viruses detected in unvaccinated backyard chickens reveals the circulation of low- and high-virulence strains

Author:
Giulia Mescolini; Caterina Lupini; Viviana Felice; Alessandro Guerrini; Flavio Silveira; Mattia Cecchinato; Elena Catelli
Source:
Poultry science 2019 v.98 no.8 pp. 3130-3137
ISSN:
0032-5791
Subject:
Gallid alphaherpesvirus 2,   etc   ; Marek disease; chickens; death; lymphatic diseases; oncogenes; paralysis; phylogeny; proline; protein isoforms; statistical analysis; transcriptional activation; virulence;     Show all 13 Subjects
Abstract:
... Marek's disease (MD) is an important lymphoproliferative disease of chickens, caused by Gallid alphaherpesvirus 2 (GaHV-2). Outbreaks are commonly reported in commercial flocks, but also in backyard chickens. Whereas the molecular characteristics of GaHV-2 strains from the commercial poultry sector have been reported, no recent data are available for the rural sector. To fill this gap, 19 GaHV-2 s ...
DOI:
10.3382/ps/pez095

20. Newly detected mutations in the Meq oncogene and molecular pathotyping of very virulent Marek’s disease herpesvirus in Tunisia

Author:
Jihene Lachheb; Houssem Mastour; Jihene Nsiri; Khaled Kaboudi; Imed Choura; Faten Ammouna; Abdelkader Amara; Abdeljelil Ghram
Source:
Archives of virology 2020 v.165 no.11 pp. 2589-2597
ISSN:
0304-8608
Subject:
Gallid alphaherpesvirus 2,   etc   ; DNA; Marek disease; amino acid substitution; chickens; classification; farmers; financial economics; immune response; lymphocytes; neoplasms; oncogenes; pathotypes; phylogeny; quantitative polymerase chain reaction; sampling; serotypes; tissues; vaccination; vaccines; virology; virulence; viruses; Tunisia;     Show all 24 Subjects
Abstract:
... Marek's disease (MD) is a contagious avian viral disease that is responsible for large economic losses to farmers. The disease is caused by Marek's disease virus (species Gallid alphaherpesvirus 2), which causes neurological lesions, immune suppression, and tumor proliferation of lymphoid cells that invade a large number of organs and tissues. Despite widespread vaccination, Marek's disease virus ...
DOI:
10.1007/s00705-020-04790-5