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- Gandhapudi, Siva K., et al. Show all 5 Authors
- Infection and immunity 2011 v.79 no.1 pp. 177-184
- Listeria monocytogenes; T-lymphocytes; bacteria; blood serum; death; fever; genes; heat stress; interferon-gamma; mice; neutralization; pathogens; septic shock; transcription factors; tumor necrosis factor-alpha
- ... Heat shock factor 1 (HSF1) is a stress-induced transcription factor that promotes expression of genes that protect mammalian cells from the lethal effects of severely elevated temperatures (>42°C). However, we recently showed that HSF1 is activated at a lower temperature (39.5°C) in T cells, suggesting that HSF1 may be important for preserving T cell function during pathogen-induced fever response ...
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