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- Gao, Chong Feng, et al. Show all 4 Authors
- Veterinary microbiology 2010 v.146 no.1-2 pp. 111-117
- cattle; Bacillus anthracis; anthrax; bacterial toxins; biochemical pathways; transcription factors; tumor necrosis factor-alpha; macrophages; cell lines; dosage; dose response; cell death; active transport; signal transduction; caspases
- ... Anthrax lethal toxin (LeTx) is an important virulence factor of Bacillus anthracis and causes illness and lethality for both animals and humans. Because species demonstrate varied sensitivity to anthrax intoxication, we investigated signaling pathways involved in anthrax LeTx cytotoxicity using a bovine macrophage cell line (BoMac). We found that bovine macrophages are sensitive to LeTx as display ...