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- García-Orad, África, et al. Show all 8 Authors
- Chromosome research 2015 v.23 no.2 pp. 285-298
- Down syndrome; chromosome mapping; chromosomes; congenital abnormalities; gene expression; genes; humans; interphase; pathogenesis; trisomics
- ... Down syndrome is a common birth defect caused by trisomy of chromosome 21. Chromosomes occupy distinct territories in interphase nuclei, and their distribution within the nuclear space is nonrandom. In humans with Down syndrome, two chromosomes 21 frequently localize proximal to one another and distant from the third chromosome. Here, we investigated the nuclear organization of DYRK1A and SOD1, tw ...
- Garcia-Orad, Africa, et al. Show all 3 Authors
- Chromosome research 2001 v.9 no.6 pp. 487-494
- Chinese hamsters; Robertsonian translocation; X chromosome; anaphase; antibodies; centromeres; cytoplasm; heterochromatin; histones; males; mice; phosphorylation; telomeres
- ... Inferences about the role and location of phosphorylated histone H3 are derived primarily from biochemical studies. A few direct observations at chromosome level have shown that phosphorylation begins at the site of heterochromatin and spreads throughout the chromosome. However, a comparative study of chromosomes of mouse (L929 cells), Chinese hamster (CHO 9 cells) and the Indian muntjac (male cel ...