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- Gilcrease, Michael, et al. Show all 23 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.24 pp. 8838-8843
- biopsy; breast neoplasms; genes; high-throughput nucleotide sequencing; humans; hypoxia; metastasis; mutation; myeloid leukemia; nanoparticles; nitric oxide synthase; patients; signal transduction; small interfering RNA; stem cells
- ... We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) and myeloid leukemia factor 2 (MLF2) as the top candidates that affect BCSC self-renewal. Knockdown of RPL39 and MLF2 by specific siRNA nanoparticles in patient-derived and human cancer xenografts reduced tumor volume and lu ...
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