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- Gong, Fu-Lian, et al. Show all 9 Authors
- The international journal of biochemistry & cell biology 2017 v.93 pp. 1-11
- antineoplastic activity; apoptosis; carcinoma; caspase-9; cell growth; colchicine; cyclins; cytochrome c; drug therapy; humans; inhibitory concentration 50; membrane potential; mice; microtubules; mitochondrial membrane; multiple drug resistance; phosphorylation
- ... Multidrug resistance (MDR) is one of major obstacles to effective chemotherapeutic treatment of cancer. This study showed that DHPAC, 2-(6-ethoxy-3-(3-ethoxyphenylamino) −1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-7-yloxy) acetamide, a novel compound that binds to the same site on microtubules as colchicine, has high anti-tumour activity in vincristine-resistant oral epidermoid carcinoma (KB/V) cell ...