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- Goulart, Camila, et al. Show all 6 Authors
- Toxicon 2015 v.108 pp. 11-14
- Cicuta; gamma-aminobutyric acid receptors; plant extracts; poisonous plants; polyacetylenes; toxicity; tubers
- ... Water hemlocks (Cicuta spp.) are acutely toxic members of the Umbellierae family; the toxicity is due to the presence of C17-polyacetylenes such as cicutoxin. There is only limited evidence of noncompetitive antagonism by C17-polyacetylenes at GABAA receptors. In this work with WSS-1 cells, we documented the noncompetitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta ...
- Goulart, Camila Oliveira, et al. Show all 11 Authors
- Methods 2016 v.99 pp. 9-36
- allergenicity; autografting; biocompatibility; biocompatible materials; biodegradability; blood vessels; cell viability; electron microscopy; extrusion; mice; models; morphometry; nerve fibers; nerve tissue; polyesters; polylactic acid; porous media; quantitative analysis
- ... Polymeric biomaterials are often used for stimulating nerve regeneration. Among different conduits, poly(lactide acid) – PLA polymer is considered to be a good substrate due to its biocompatibility and resorbable characteristics. This polymer is an aliphatic polyester which has been mostly used in biomedical application. It is an organic compound with low allergenic potential, low toxicity, high b ...