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- Gries, Barbara, et al. Show all 7 Authors
- Cell and tissue research 2016 v.364 no.2 pp. 245-262
- G-protein coupled receptors; Western blotting; acid-base balance; alpha-ketoglutaric acid; energy; immunohistochemistry; ligands; messenger RNA; mice; neurons; succinic acid; tissues; tricarboxylic acid cycle; vacuoles
- ... Energy substrates and metabolic intermediates are proven ligands of a growing number of G-protein coupled receptors. In 2004, GPR91 and GPR99 were identified as receptors for the citric acid cycle intermediates, succinate and α-ketoglutarate, respectively. GPR91 seems to act as a first responder to local stress and GPR99 participates in the regulation of the acid–base balance through an intrarenal ...