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- GuoCuiping Guo and Yu Chang contributed equally to this work., Cuiping, et al. Show all 7 Authors
- Chemical communications 2019 v.55 no.6 pp. 834-837
- chemical compounds; chemical reactions; drugs; image analysis; moieties; protein composition; proteome; screening
- ... Activity-based protein profiling (ABPP) and bioimaging have been powerful approaches for in situ drug screening and target identification. However, these approaches are still hindered by the preparation of high-quality probes. To address this challenge, we developed a series of novel minimalist linkers for irreversible inhibitors by incorporation of various bioorthogonal handles into an α,β-unsatu ...