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- Gurnani, Komal, et al. Show all 10 Authors
- Analytical chemistry 2018 v.90 no.19 pp. 11409-11416
- amino acids; cell lines; derivatization; epitopes; hydrophobicity; ionization; liquid chromatography; major histocompatibility complex; neoplasms; patients; peptides; tandem mass spectrometry; therapeutics; vaccines
- ... Neoantigen-based therapeutic vaccines have a high potential impact on tumor eradication and patient survival. Mass spectrometry (MS)-based immunopeptidomics has the capacity to identify tumor-associated epitopes and pinpoint mutation-bearing major histocompatibility complex (MHC)-binding peptides. This approach presents several challenges, including the identification of low-abundance peptides. In ...